Gut microbiota modulates lung fibrosis severity following acute lung injury in mice

Autor: Ozioma S. Chioma, Elizabeth K. Mallott, Austin Chapman, Joseph C. Van Amburg, Hongmei Wu, Binal Shah-Gandhi, Nandita Dey, Marina E. Kirkland, M. Blanca Piazuelo, Joyce Johnson, Gordon R. Bernard, Sobha R. Bodduluri, Steven Davison, Bodduluri Haribabu, Seth R. Bordenstein, Wonder P. Drake

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)

Direct modulation of the gut microbiota via rearing environments and fecal microbiota transplantation in a bleomycin-induced murine model suggests that a functional gut-lung axis modulates lung fibrosis.

Externí odkaz: https://doaj.org/article/8dea445273114084825787a1400a2004

Insights from an Intervention to Support Early Career Faculty with Extraprofessional Caregiving Responsibilities

Autor: Lauren A. Szczygiel, Rochelle D. Jones, Amelia F. Drake, Wonder P. Drake, Daniel E. Ford, Katherine E. Hartmann, Anne M. Libby, Bess A. Marshall, Judith G. Regensteiner, Kristine Yaffe, Reshma Jagsi

Publikováno v: Women's Health Reports, Vol 2, Iss 1, Pp 355-368 (2021)

Background: Insufficient support for balancing career and family responsibilities hinders retention of physician-scientists. Programs to improve retention of this important group of faculty are crucial. Understanding the experiences of program implem

Externí odkaz: https://doaj.org/article/8d7f149a88ea49708c5d06b4fa46f4d3

Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease

Autor: Ozioma S. Chioma, Elizabeth Mallott, Binal Shah-Gandhi, ZaDarreyal Wiggins, Madison Langford, Andrew William Lancaster, Alexander Gelbard, Hongmei Wu, Joyce E. Johnson, Lisa Lancaster, Erin M. Wilfong, Leslie J. Crofford, Courtney G. Montgomery, Luc Van Kaer, Seth Bordenstein, Dawn C. Newcomb, Wonder Puryear Drake

Publikováno v: Cells, Vol 12, Iss 5, p 766 (2023)

Although profibrotic cytokines, such as IL-17A and TGF-β1, have been implicated in the pathogenesis of interstitial lung disease (ILD), the interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic cytokine ex

Externí odkaz: https://doaj.org/article/2b5fde885bc54e49986452f6ae18e637

Role of the Microbiome in Interstitial Lung Diseases

Autor: Ozioma S. Chioma, Laura E. Hesse, Austin Chapman, Wonder P. Drake

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

There are trillions of microorganisms in the human body, consisting of bacteria, viruses, fungi, and archaea; these collectively make up the microbiome. Recent studies suggest that the microbiome may serve as a biomarker for disease, a therapeutic ta

Externí odkaz: https://doaj.org/article/5280b7a324574c0691ed27d79c25792e

Advancing Lung Immunology Research An Official American Thoracic Society Workshop Report

Autor: Rod A. Rahimi, Josalyn L. Cho, Claudia V. Jakubzick, Shabaana A. Khader, Bart N. Lambrecht, Clare M. Lloyd, Ari B. Molofsky, Sebastien Talbot, Catherine A. Bonham, Wonder P. Drake, Anne I. Sperling, Benjamin D. Singer

Publikováno v: American journal of respiratory cell and molecular biology, vol 67, iss 1
American Journal of Respiratory Cell and Molecular Biology, 67(1), E1-E18. American Thoracic Society

The mammalian airways and lungs are exposed to a myriad of inhaled particulate matter, allergens, and pathogens. The immune system plays an essential role in protecting the host from respiratory pathogens, but a dysregulated immune response during re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c2b9c4674f235ecf40bd1bdcb74d58
https://doi.org/10.1165/rcmb.2022-0167ST