Zobrazeno 1 - 10
of 20
pro vyhledávání: '"WonCheol Kim"'
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108933- (2024)
Summary: Neuritogenesis is crucial for establishing proper neuronal connections during brain development; its failure causes neurodevelopmental defects. Cullin-RING E3 ubiquitin ligase complexes participate in various neurodevelopmental processes by
Externí odkaz:
https://doaj.org/article/7e955b8861874e699f1bc044d523420e
Neuritogenesis is critical for the establishment of proper neuronal connections during brain development. Thus, its failure causes neurodevelopmental defects such as intellectual disabilities. Cullin-RING E3 ubiquitin-ligase complexes are involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::691bca2bce0b04d6076d2d5fcadfc7ca
https://doi.org/10.21203/rs.3.rs-1972814/v1
https://doi.org/10.21203/rs.3.rs-1972814/v1
Autor:
Robert W. Haushalter, Woncheol Kim, Ted A. Chavkin, Lionadi The, Megan E. Garber, Melissa Nhan, Paul D. Adams, Christopher J. Petzold, Leonard Katz, Jay D. Keasling
Publikováno v:
Metabolic Engineering. 26:111-118
Microbial fermentation is emerging as an increasingly important resource for the production of fatty acids to serve as precursors for renewable diesel as well as detergents, lubricants and other industrial chemicals, as an alternative to traditional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9deca1499964575dd6a599608acef05
Autor:
Dokyeong Kim, Kwangsu Kim, Cheil Moon, Woncheol Kim, Jiyun Choe, Yoojin Roh, Kyu Bo Kim, Seung-Hee Lee
Publikováno v:
IBRO Reports. 6:S323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e918990619a572e46ce2277da4c83337
https://doi.org/10.1016/j.ibror.2019.07.998
https://doi.org/10.1016/j.ibror.2019.07.998
Publikováno v:
Angewandte Chemie International Edition. 51:11136-11140
A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665c0ea397ddc3aef7f9e0173f72c2a1
https://doi.org/10.1002/anie.201205426
https://doi.org/10.1002/anie.201205426
Publikováno v:
Journal of Microbiology and Biotechnology. 20:1484-1490
In the Streptomyces hygroscopicus JCM4427 geldanamycin biosynthetic gene cluster, Five putative regulatory genes were identified by protein homology searching. Among three of those genes, gel14, gel17, and gel19, are located downstream of polyketide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697e11782836d223ed760f4794b16e89
https://doi.org/10.4014/jmb.1005.05040
https://doi.org/10.4014/jmb.1005.05040
Publikováno v:
Current opinion in biotechnology. 23(5)
Heterologous production of polyketide compounds, an important class of natural products with complex chemical structures, was first demonstrated with Streptomyces parvulus in 1984. Although Streptomyces strains are good first options for heterologous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf4be480416f9d99165621e16b87e25
https://pubmed.ncbi.nlm.nih.gov/22244790
https://pubmed.ncbi.nlm.nih.gov/22244790
SF2575 1 is a tetracycline polyketide produced by Streptomyces sp. SF2575 and displays exceptionally potent anticancer activity toward a broad range of cancer cell lines. The structure of SF2575 is characterized by a highly substituted tetracycline a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c119e83bda617ddf1ec7e88735a270
https://europepmc.org/articles/PMC2800175/
https://europepmc.org/articles/PMC2800175/
Autor:
Young-Soo Hong, Seong Su Hong, Zhu Na, Woncheol Kim, Cheng Zhu Wu, Kyeong Lee, Dongho Lee, Oksik Choi, Sang Gi Paik, Su Heun Roh, Jung Joon Lee, Jin Chul Shin, Yue-Mao Shen
Publikováno v:
Chembiochem : a European journal of chemical biology. 10(7)
Tailor made: We report the rational biosynthesis of C15 hydroxylated non-quinone geldanamycin analogues by site-directed mutagenesis of the geldanamycin polyketide synthase (PKS), together with a combination of post-PKS tailoring genes. Rational bios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f5eca90ed7961972794b8fcd4e496f
https://pubmed.ncbi.nlm.nih.gov/19308924
https://pubmed.ncbi.nlm.nih.gov/19308924
Autor:
Joon-Tae Park, Hong S. Lee, Yinglan Jin, Sang J. Chung, Navneet Kaur, Jung S. Ryu, Woncheol Kim, Jung J. Lee, Yong-Jin Jeon, Ji S. Bang, Young-Soo Hong, Tae Y. Kim, Kyeong Lee
Publikováno v:
Organicbiomolecular chemistry. 6(2)
A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e12697e6beeb0928a30c405a9f563a
https://pubmed.ncbi.nlm.nih.gov/18175003
https://pubmed.ncbi.nlm.nih.gov/18175003