Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Won-sik Yeo"'
Autor:
Augustus Pendleton, Won-Sik Yeo, Shahad Alqahtani, Dennis A. DiMaggio, Carl J. Stone, Zhaotao Li, Vineet K. Singh, Christopher P. Montgomery, Taeok Bae, Shaun R. Brinsmade
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Staphylococcus aureus is a ubiquitous Gram-positive bacterium and an opportunistic human pathogen. S. aureus pathogenesis relies on a complex network of regulatory factors that adjust gene expression. Two important factors in this network ar
Externí odkaz:
https://doaj.org/article/ca8119e7cbe4480488831df51158cfed
Publikováno v:
Antibiotics, Vol 10, Iss 10, p 1198 (2021)
In the Gram-positive pathogen Staphylococcus aureus, FtsH, a membrane-bound metalloprotease, plays a critical role in bacterial virulence and stress resistance. This protease is also known to sensitize methicillin-resistant Staphylococcus aureus (MRS
Externí odkaz:
https://doaj.org/article/3dfdd376948d4bd0abc9c5a36b50da05
Autor:
Qian Liu, Mo Hu, Won-Sik Yeo, Lei He, Tianming Li, Yuanjun Zhu, Hongwei Meng, Yanan Wang, Hyunwoo Lee, Xiaoyun Liu, Min Li, Taeok Bae
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract In the Gram-positive pathogen Staphylococcus aureus, the membrane-bound ATP-dependent metalloprotease FtsH plays a critical role in resistance to various stressors. However, the molecular mechanism of the FtsH functions is not known. Here, w
Externí odkaz:
https://doaj.org/article/172ed3d04f034637a863fc3a15066755
Autor:
Quanjiang Ji, Peter J. Chen, Guangrong Qin, Xin Deng, Ziyang Hao, Zdzislaw Wawrzak, Won-Sik Yeo, Jenny Winjing Quang, Hoonsik Cho, Guan-Zheng Luo, Xiaocheng Weng, Qiancheng You, Chi-Hao Luan, Xiaojing Yang, Taeok Bae, Kunqian Yu, Hualiang Jiang, Chuan He
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisatio
Externí odkaz:
https://doaj.org/article/982278f7c02745b09c2db25ee3867b43
Autor:
Qian Liu, Xing Wang, Juanxiu Qin, Sen Cheng, Won-Sik Yeo, Lei He, Xiaowei Ma, Xiaoyun Liu, Min Li, Taeok Bae
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Biofilm causes hospital-associated infections on indwelling medical devices. In Staphylococcus aureus, Biofilm formation is controlled by intricately coordinated network of regulating systems, of which the ATP-dependent protease ClpP shows an inhibit
Externí odkaz:
https://doaj.org/article/aa560a29b632495e8a2b8a0b409e5499
Autor:
Hoonsik Cho, Do-Won Jeong, Qian Liu, Won-Sik Yeo, Thomas Vogl, Eric P Skaar, Walter J Chazin, Taeok Bae
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005026 (2015)
Calprotectin, the most abundant cytoplasmic protein in neutrophils, suppresses the growth of Staphylococcus aureus by sequestering the nutrient metal ions Zn and Mn. Here we show that calprotectin can also enhance the activity of the SaeRS two compon
Externí odkaz:
https://doaj.org/article/349ff11bb06640ceb144321bf27eab97
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004799 (2015)
Bacterial pathogens often employ two-component systems (TCSs), typically consisting of a sensor kinase and a response regulator, to control expression of a set of virulence genes in response to changing host environments. In Staphylococcus aureus, th
Externí odkaz:
https://doaj.org/article/f6eadff4bb9e414897d22592042ac700
Autor:
Quanjiang Ji, Peter J. Chen, Guangrong Qin, Xin Deng, Ziyang Hao, Zdzislaw Wawrzak, Won-sik Yeo, Jenny Winjing Quang, Hoonsik Cho, Guan-Zheng Luo, Xiaocheng Weng, Qiancheng You, Chi-Hao Luan, Xiaojing Yang, Taeok Bae, Kunqian Yu, Hualiang Jiang, Chuan He
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7: Article number:11000 (2016); Published 18 March 2016: Updated 6 February 2017 In this Article, we presented a structural and functional characterization of the WalKR two-component system for signal transduction and a small mo
Externí odkaz:
https://doaj.org/article/2233302e69b14a45af7c67bc327b8c11
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT The histone-like nucleoid-structuring (H-NS) protein binds to horizontally acquired genes in the bacterium Salmonella enterica serovar Typhimurium, silencing their expression. We now report that overcoming the silencing effects of H-NS impos
Externí odkaz:
https://doaj.org/article/29e2d243150c4be5896259537139e2bf
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92723 (2014)
The emergence of antibiotic resistant microorganisms is a great public health concern and has triggered an urgent need to develop alternative antibiotics. Chitosan microparticles (CM), derived from chitosan, have been shown to reduce E. coli O157:H7
Externí odkaz:
https://doaj.org/article/0e6582f43005416ba25710a0d7df3947