Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles

Autor: Paweł Ł. Janczyk, Eliza Żyłkiewicz, Henry De Hoyos, Thomas West, Daniel R. Matson, Won-Chan Choi, Heather M. Raimer Young, Zygmunt S. Derewenda, P. Todd Stukenberg

Publikováno v: Molecular Biology of the Cell. 34

Dynein inactivates the spindle assembly checkpoint (SAC) by transporting checkpoint proteins away from kinetochores toward spindle poles in a process known as "stripping." We find that inhibition of Aurora A kinase, which is localized to spindle pole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f47bfa91ecbdfc006b52a821be925c
https://doi.org/10.1091/mbc.e21-09-0438

Abstract No. 597 Percutaneous transhepatic enteral stent placement in patients with recurrent malignant obstruction in surgically altered bowel anatomy

Autor: Chan Lee, J.K. Lee, Chong Hyun Yoon, Won Chan Choi

Publikováno v: Journal of Vascular and Interventional Radiology. 31:S260

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a610e6b3cb4e6a79d2e2a8ff56729a1
https://doi.org/10.1016/j.jvir.2019.12.658

Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein

Autor: Juergen Haas, Hye-Ra Lee, Myung Hee Kim, Stacy Lee, Jae U. Jung, Eunha Hwang, Won-Chan Choi, Koushik Guchhait, Tae-Kwang Oh, Zsolt Toth, Jungwon Hwang, Young Ho Jeon

Publikováno v: Lee, H-R, Choi, W-C, Lee, S, Hwang, J, Hwang, E, Guchhait, K, Haas, J, Toth, Z, Jeon, Y H, Oh, T-K, Kim, M H & Jung, J U 2011, ' Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein ', Nature Structural & Molecular Biology, vol. 18, no. 12, pp. 1336-44 . https://doi.org/10.1038/nsmb.2142

Herpesvirus-associated ubiquitin-specific protease (HAUSP) regulates the stability of p53 and the p53-binding protein MDM2, implicating HAUSP as a therapeutic target for tuning p53-mediated antitumor activity. Here we report the structural analysis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b387c3af1d2710a16a6e13a9d56ef677
https://doi.org/10.1038/nsmb.2142

Crystal Structure of the Human N-Myc Downstream-regulated Gene 2 Protein Provides Insight into Its Role as a Tumor Suppressor

Autor: Ho Bum Kang, Beom Sik Kang, Hwiseop Lee, Jungwon Hwang, Tae-Kwang Oh, Yoonjeong Kim, Cheol-Hee Kim, Myung Hee Kim, Jae Wha Kim, Won-Chan Choi, Ian A. Wilson, Jie-Oh Lee, Kyung-Jin Kim, Ashley M. Deacon, Lukasz Jaroszewski

Publikováno v: The Journal of Biological Chemistry

Considerable attention has recently been paid to the N-Myc downstream-regulated gene (NDRG) family because of its potential as a tumor suppressor in many human cancers. Primary amino acid sequence information suggests that the NDRG family proteins ma

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https://doi.org/10.1074/jbc.m110.170803

Crystal Structure of SmcR, a Quorum-sensing Master Regulator of Vibrio vulnificus, Provides Insight into Its Regulation of Transcription

Autor: Beom Sik Kang, Yu Jin Park, Tae Kwang Oh, Myung Hee Kim, Sang-Ho Choi, Jungwon Hwang, Yoonjeong Kim, Won Chan Choi, Byoung Sik Kim

Publikováno v: The Journal of Biological Chemistry

Quorum sensing has been implicated as an important global regulatory system controlling the expression of numerous virulence factors in bacterial pathogens. SmcR, a homologue of Vibrio harveyi LuxR, has been proposed as a quorum-sensing master regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9d7d05508548ca2907a8c17face22f
https://doi.org/10.1074/jbc.m109.100248