Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Won Mo Yang"'
Autor:
Srinivas Pittala, Dhanush Haspula, Yinghong Cui, Won-Mo Yang, Young-Bum Kim, Roger J. Davis, Allison Wing, Yaron Rotman, Owen P. McGuinness, Asuka Inoue, Jürgen Wess
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Altered hepatic glucose fluxes are critical during the pathogenesis of type 2 diabetes. G protein-coupled receptors represent important regulators of hepatic glucose production. Recent studies have shown that hepatocytes express GPCRs that c
Externí odkaz:
https://doaj.org/article/4dfdfbf6265845d1abd626cbda00bf22
Autor:
Kellen Cristina da Cruz Rodrigues, Seung Chan Kim, Aaron Aykut Uner, Zhi-Shuai Hou, Jennie Young, Clara Campolim, Ahmet Aydogan, Brendon Chung, Anthony Choi, Won-Mo Yang, Woojin S. Kim, Vincent Prevot, Barbara J. Caldarone, Hyon Lee, Young-Bum Kim
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101941- (2024)
Objective: Low-density lipoprotein receptor-related protein-1 (LRP1) regulates energy homeostasis, blood–brain barrier integrity, and metabolic signaling in the brain. Deficiency of LRP1 in inhibitory gamma-aminobutyric acid (GABA)ergic neurons cau
Externí odkaz:
https://doaj.org/article/e55f3e4f47234ed2a72826ad4425a226
Autor:
Byung-Jun Sung, Sung-Bin Lim, Won-Mo Yang, Jae Hyeon Kim, Rohit N. Kulkarni, Young-Bum Kim, Moon-Kyu Lee
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101625- (2022)
Objective: The endocrine pancreatic β-cells play a pivotal role in maintaining whole-body glucose homeostasis and its dysregulation is a consistent feature in all forms of diabetes. However, knowledge of intracellular regulators that modulate β-cel
Externí odkaz:
https://doaj.org/article/fd333657c2f84dc983ca4910335470e3
Autor:
Ji A Seo, Min-Cheol Kang, Won-Mo Yang, Won Min Hwang, Sang Soo Kim, Soo Hyun Hong, Jee-In Heo, Achana Vijyakumar, Leandro Pereira de Moura, Aykut Uner, Hu Huang, Seung Hwan Lee, Inês S. Lima, Kyong Soo Park, Min Seon Kim, Yossi Dagon, Thomas E. Willnow, Vanita Aroda, Theodore P. Ciaraldi, Robert R. Henry, Young-Bum Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Hepatokines are proteins secreted by the liver that can regulate whole body metabolism. Here the authors identify apolipoprotein J as a hepatokine that regulates muscle glucose metabolism and insulin resistance through a low-density lipoprotein recep
Externí odkaz:
https://doaj.org/article/6735e33c49584e2dadb77deb37175325
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 882-886 (2017)
The ectopic expression of miR-15b is linked causally to impaired insulin signaling in human HepG2 hepatocytes through the suppression of INSR (Yang et al., 2015) [1]. In this data article, we further examined the effect of miR-15b on insulin signalin
Externí odkaz:
https://doaj.org/article/4284342819b140739db9434765649c0c
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 800-804 (2017)
Obesity and metabolic diseases are closely associated with insulin resistance. Obesity-induced miRNAs are also considered to be potential contributors to the development of insulin resistance and type 2 diabetes. Previously, the expression of miR-127
Externí odkaz:
https://doaj.org/article/376ceb72499548ed98581a14fe007e6b
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 747-751 (2017)
Dietary fats rich in saturated fatty acid (SFA) increase the risk of metabolic diseases, and certain microRNAs (miRNAs) dysregulated by SFA are associated with the pathogenesis of insulin resistance and type 2 diabetes. A previous study found that mi
Externí odkaz:
https://doaj.org/article/cd657d814ee84b2db807bbd4f3af40c3
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 728-732 (2017)
Diets containing a high saturated fatty acid (SFA) increase the risk of metabolic diseases, and microRNAs (miRNAs) induced by SFA have been implicated in the pathogenesis of insulin resistance and type 2 diabetes. In a previous report, miR-96 is foun
Externí odkaz:
https://doaj.org/article/4ba3b645471d4423b05acc9842213625
Publikováno v:
Data in Brief, Vol 11, Iss C, Pp 266-272 (2017)
Changes in the mitochondrial DNA (mtDNA) content are believed to initiate a stress signal that leads to alterations in nuclear gene expression. This article presents data on the identification of nuclear genes that are expressed differentially in res
Externí odkaz:
https://doaj.org/article/efe7b12034014169a0eb967e52587efa
Publikováno v:
Pharmaceutical Biology, Vol 55, Iss 1, Pp 1324-1329 (2017)
Context: Spirodela polyrhiza (L.) Schleid. (Lemnaceae), Spirodelae Herba (SH), has been known to relieve inflammation, urticaria and skin symptoms including pruritus, eczema and rash. Objective: The effects of SH extract on two calcium ion channels,
Externí odkaz:
https://doaj.org/article/0883fce137c44e8895ca5cd56b9c58e0