Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Won Jong Jin"'
Autor:
Kathleen A. O’Leary, Amber M. Bates, Won Jong Jin, Brian M. Burkel, Raghava N. Sriramaneni, Sarah E. Emma, Erin J. Nystuen, Elizabeth G. Sumiec, Suzanne M. Ponik, Zachary S. Morris, Linda A. Schuler
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background Most patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these cancers is generally immunosuppressive and contains few tumor-infilt
Externí odkaz:
https://doaj.org/article/ed62145c75cf435aa09efab35a43623c
Autor:
Won Jong Jin, Justin C. Jagodinsky, Jessica M. Vera, Paul A. Clark, Cindy L. Zuleger, Amy K. Erbe, Irene M. Ong, Trang Le, Kaitlin Tetreault, Tracy Berg, Alexander L. Rakhmilevich, KyungMann Kim, Michael A. Newton, Mark R. Albertini, Paul M. Sondel, Zachary S. Morris
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113556- (2023)
Summary: We report an in situ vaccination, adaptable to nearly any type of cancer, that combines radiotherapy targeting one tumor and intratumoral injection of this site with tumor-specific antibody and interleukin-2 (IL-2; 3xTx). In a phase I clinic
Externí odkaz:
https://doaj.org/article/3b49ec059cc6419f9fcdd7b1869fd235
Autor:
Zachary S Morris, Won Jong Jin, Luke M Zangl, Meredith Hyun, Elian Massoud, Kaleb Schroeder, Roxana A Alexandridis
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background Radiation therapy (RT) elicits DNA double-strand breaks, resulting in tumor cytotoxicity and a type I interferon (IFN) response via stimulator of interferon genes (STING) activation. We investigated whether combining RT with an ataxia-tela
Externí odkaz:
https://doaj.org/article/09fe93ac88ba4abb95865b23c2940f95
Autor:
Zachary S Morris, KyungMann Kim, Paul M Sondel, Paul A Clark, Raghava N Sriramaneni, Won Jong Jin, Justin C Jagodinsky, Amber M Bates, Ishan Chakravarty, Thomas C Havighurst, Erin J Nystuen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background Radiation therapy (RT) has been demonstrated to generate an in situ vaccination (ISV) effect in murine models and in patients with cancer; however, this has not routinely translated into enhanced clinical response to immune checkpoint inhi
Externí odkaz:
https://doaj.org/article/4fb8533924bd4b09b31e36bf63136f4d
Autor:
Willem W Overwijk, Zachary S Morris, Paul M Sondel, Deborah H Charych, Amy K Erbe, Jacquelyn A Hank, Alexander L Rakhmilevich, Won Jong Jin, Peter M Carlson, Alexander A Pieper, Ravi B Patel, Daniel V Spiegelman, Jen Birstler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Current clinical trials are using radiation therapy (RT) to enhance an antitumor response elicited by high-dose interleukin (IL)-2 therapy or immune checkpoint blockade (ICB). Bempegaldesleukin (BEMPEG) is an investigational CD122-preferen
Externí odkaz:
https://doaj.org/article/07a432011bbe452ebe7af0fdcf7d01a3
Autor:
Won Jong Jin, Amy K. Erbe, Ciara N. Schwarz, Abigail A. Jaquish, Bryce R. Anderson, Raghava N. Sriramaneni, Justin C. Jagodinsky, Amber M. Bates, Paul A. Clark, Trang Le, Keng-Hsueh Lan, Yi Chen, KyungMann Kim, Zachary S. Morris
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In head and neck squamous cell carcinoma (HNSCC) tumors that over-expresses huEGFR, the anti-EGFR antibody, cetuximab, antagonizes tumor cell viability and sensitizes to radiation therapy. However, the immunologic interactions between cetuximab and r
Externí odkaz:
https://doaj.org/article/cb1c402282874fdc932a12949b4cd965
Autor:
Claire C. Baniel, Clinton M. Heinze, Anna Hoefges, Elizabeth G. Sumiec, Jaquelyn A. Hank, Peter M. Carlson, Won Jong Jin, Ravi B. Patel, Raghava N. Sriramaneni, Stephen D. Gillies, Amy K. Erbe, Ciara N. Schwarz, Alexander A. Pieper, Alexander L. Rakhmilevich, Paul M. Sondel, Zachary S. Morris
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In a syngeneic murine melanoma (MEL) model, we recently reported an in situ vaccination response to combined radiation (RT) and intra-tumoral (IT) injection of anti-GD2 hu14. 18-IL2 immunocytokine (IC). This combined treatment resulted in 71% complet
Externí odkaz:
https://doaj.org/article/69d352c38672413f9676b26e4741f6de
Publikováno v:
Data in Brief, Vol 18, Iss , Pp 518-522 (2018)
C-X-C motif chemokine receptor 3 (CXCR3) is a G protein-coupled receptor for three ligands which are C-X-C motif chemokine 9 (CXCL9), CXCL10, and CXCL11 [1]. Previously we have reported that CXCL10 promotes pro-inflammatory cytokine expression, and f
Externí odkaz:
https://doaj.org/article/6449a969b05b4f46a414084d7dda02f9
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-14 (2017)
Abstract Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by uncontrolled joint inflammation and destruction of bone and cartilage. We previously reported that C-X-C motif chemokine 10 (CXCL10; also called IP-10) has
Externí odkaz:
https://doaj.org/article/0b87eeeebcd646f5b620080eddf7351a
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 682-685 (2016)
The data in this article is related to the research article entitled “Notch2 signaling promotes osteoclast resorption via activation of PYK2” (Jin et al., 2016 [1]). To block Notch signaling activation, we used several gamma-secretase inhibitors
Externí odkaz:
https://doaj.org/article/978018dc31b049028ef76a95baea4e6b