Application of an organotypic ocular perfusion model to assess intravitreal drug distribution in human and animal eyes.

Autor: Chan D; Donald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada., Won GJ; Donald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada., Read AT; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA., Ethier CR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA., Thackaberry E; Safety Assessment, Genentech Inc., San Francisco, CA, USA., Crowell SR; Preclinical and Translational Pharmacokinetics and Pharmacodynamics (PTPK) Genentech Inc., San Francisco, CA, USA., Booler H; Safety Assessment, Genentech Inc., San Francisco, CA, USA., Bantseev V; Safety Assessment, Genentech Inc., San Francisco, CA, USA., Sivak JM; Donald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Journal of the Royal Society, Interface [J R Soc Interface] 2022 Jan; Vol. 19 (186), pp. 20210734. Date of Electronic Publication: 2022 Jan 26.

Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury.

Autor: Livne-Bar I; Department of Vision Sciences, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada., Wei J; Vision Science Program, School of Optometry, University of California at Berkeley, Berkeley, California, USA., Liu HH; Vision Science Program, School of Optometry, University of California at Berkeley, Berkeley, California, USA., Alqawlaq S; Department of Vision Sciences, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Won GJ; Department of Vision Sciences, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada., Tuccitto A; Department of Vision Sciences, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Gronert K; Vision Science Program, School of Optometry, University of California at Berkeley, Berkeley, California, USA., Flanagan JG; Vision Science Program, School of Optometry, University of California at Berkeley, Berkeley, California, USA., Sivak JM; Department of Vision Sciences, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2017 Dec 01; Vol. 127 (12), pp. 4403-4414. Date of Electronic Publication: 2017 Nov 06.