Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Won Bin Young"'
Autor:
Yu Liu, Feng-Zhen Meng, Xu Wang, Peng Wang, Jin-Biao Liu, Wen-Hui Hu, Won-Bin Young, Wen-Zhe Ho
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Background Methamphetamine (METH), a potent addictive psychostimulant, is highly prevalent in HIV-infected individuals. Clinically, METH use is implicated in alteration of immune system and increase of HIV spread/replication. Therefore, it i
Externí odkaz:
https://doaj.org/article/782e61a2422e42c3a01f37859d6dc0fa
Autor:
Prasanta K. Dash, Rafal Kaminski, Ramona Bella, Hang Su, Saumi Mathews, Taha M. Ahooyi, Chen Chen, Pietro Mancuso, Rahsan Sariyer, Pasquale Ferrante, Martina Donadoni, Jake A. Robinson, Brady Sillman, Zhiyi Lin, James R. Hilaire, Mary Banoub, Monalisha Elango, Nagsen Gautam, R. Lee Mosley, Larisa Y. Poluektova, JoEllyn McMillan, Aditya N. Bade, Santhi Gorantla, Ilker K. Sariyer, Tricia H. Burdo, Won-Bin Young, Shohreh Amini, Jennifer Gordon, Jeffrey M. Jacobson, Benson Edagwa, Kamel Khalili, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-o
Externí odkaz:
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Autor:
Ramona Bella, Rafal Kaminski, Pietro Mancuso, Won-Bin Young, Chen Chen, Rahsan Sariyer, Tracy Fischer, Shohreh Amini, Pasquale Ferrante, Jeffrey M. Jacobson, Fatah Kashanchi, Kamel Khalili
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 275-282 (2018)
We used NOD/SCID mice, also known as NRG, to assess the ability of lentivirus-mediated intravenous delivery of CRISPR in editing the HIV-1 genome from the circulating PBMC engrafts, some of which homed within several animal solid tissues. Lentivirus-
Externí odkaz:
https://doaj.org/article/c3b71237f904449d850998e4e755e66e
Autor:
Junxiao Deng, Xiying Qu, Panpan Lu, Xinyi Yang, Yuqi Zhu, Haiyan Ji, Yanan Wang, Zhengtao Jiang, Xian Li, Yangcheng Zhong, He Yang, Hanyu Pan, Won-Bin Young, Huanzhang Zhu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 233-242 (2017)
HIV-1 inserts its proviral DNA into the infected host cells, by which HIV proviral DNA can then be duplicated along with each cell division. Thus, provirus cannot be eradicated completely by current antiretroviral therapy. We have developed an innova
Externí odkaz:
https://doaj.org/article/8d195c47f1424fe5b8be022e7106d31b
Autor:
Xiying Qu, Won-Bin Young
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss , Pp 26- (2016)
Externí odkaz:
https://doaj.org/article/f1373727bd7a447eae12095950c7e55c
Autor:
Won-Bin Young, Xiying Qu
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss , Pp 38- (2016)
Externí odkaz:
https://doaj.org/article/9bd5b5c080cc4555a45d9a181cd42d2e
Publikováno v:
BioTechniques, Vol 50, Iss 4, Pp 229-234 (2011)
Quantification of inflammation in tissue samples can be a time-intensive bottleneck in therapeutic discovery and preclinical endeavors. We describe a versatile and rapid approach to quantitatively assay macrophage burden in intact tissue samples. Per
Externí odkaz:
https://doaj.org/article/28553551bda24bbbb3c44169ec92dd8a
Autor:
Feng-Zhen Meng, Wen-Zhe Ho, Wenhui Hu, Jin-Biao Liu, Xu Wang, Peng Wang, Won-Bin Young, Yu Liu
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-9 (2021)
Cell & Bioscience
Cell & Bioscience
Background Methamphetamine (METH), a potent addictive psychostimulant, is highly prevalent in HIV-infected individuals. Clinically, METH use is implicated in alteration of immune system and increase of HIV spread/replication. Therefore, it is of impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51091e844b36293eb7073557932cc0a
https://doi.org/10.1186/s13578-021-00703-4
https://doi.org/10.1186/s13578-021-00703-4
Autor:
Santhi Gorantla, James R. Hilaire, Won Bin Young, Shohreh Amini, JoEllyn M McMillan, Brady Sillman, Chen Chen, Hang Su, Mary G. Banoub, Kamel Khalili, Howard E. Gendelman, Prasanta K. Dash, Jennifer Gordon, Larisa Y. Poluektova, Nagsen Gautam, Martina Donadoni, Rahsan Sariyer, Pietro Mancuso, Saumi Mathews, Rafal Kaminski, Monalisha Elango, R. Lee Mosley, Tricia H. Burdo, Jeffrey M. Jacobson, Benson J Edagwa, Taha Mohseni Ahooyi, Pasquale Ferrante, Jake A. Robinson, Zhiyi Lin, Ramona Bella, Ilker Kudret Sariyer, Aditya N. Bade
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27b73c3e4c0b82ed8decf5430a2d869
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Publikováno v:
BioTechniques, Vol 28, Iss 3, Pp 562-565 (2000)
Externí odkaz:
https://doaj.org/article/705eae8b9b7146caa38fc336edaf0bf1