Can Machine Learning Models Predict Asparaginase-associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia.

Autor: Nielsen RL; Departments of Health Technology.; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet.; Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Huairou, China., Wolthers BO; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet., Helenius M; Departments of Health Technology., Albertsen BK; Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark., Clemmensen L; Department of Applied Mathematics and Computer Science, Kgs. Lyngby., Nielsen K; Center for Biological Sequence Analysis, Technical University of Denmark., Kanerva J; Children's Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki., Niinimäki R; Oulu University Hospital, Department of Children and Adolescents, and University of Oulu, PEDEGO Research Unit, Oulu, Finland., Frandsen TL; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet., Attarbaschi A; Department of Pediatric Hematology and Oncology, St Anna Children's Hospital and Department of Pediatric and Adolescent Medicine, Medical University of Vienna, Wien, Austria., Barzilai S; Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petah-Tikva, Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Colombini A; Department of Pediatrics, Ospedale San Gerardo, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy., Escherich G; Clinic of Pediatric Hematology and Oncology, University Medical Center Eppendorf, Hamburg., Aytan-Aktug D; Bioinformatics., Liu HC; Division of Pediatric Hematology-Oncology, Mackay Memorial Hospital, Taipei, Taiwan., Möricke A; Department of Pediatrics, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel., Samarasinghe S; Great Ormond Street Hospital for Children, London, UK., van der Sluis IM; Dutch Childhood Oncology Group, The Hague and Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Stanulla M; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Tulstrup M; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet., Yadav R; Center for Biological Sequence Analysis, Technical University of Denmark., Zapotocka E; Department of Pediatric Hematology/Oncology, University Hospital Motol, Prague, Czech Republic., Schmiegelow K; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet.; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen., Gupta R; Departments of Health Technology.

Publikováno v: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2022 Apr 01; Vol. 44 (3), pp. e628-e636.

Pancreatitis-associated protein as an early marker of asparaginase-associated pancreatitis.

Autor: Lukes J; CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Wolthers BO; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark., Altaf Raja R; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark., Uhrinova K; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Skvarova Kramarzova K; CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Hermanova I; CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Simcikova M; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Kicko P; Department of Dermatovenereology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Zaliova M; CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Sramkova L; CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Stary J; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Trka J; CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Schmiegelow K; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark., Starkova J; CLIP - Childhood Leukaemia Investigation Prague, Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic.

Publikováno v: Leukemia & lymphoma [Leuk Lymphoma] 2021 Dec; Vol. 62 (14), pp. 3506-3510. Date of Electronic Publication: 2021 Aug 09.

Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository.

Autor: Saito T; Department of Pediatrics, Stanford University, 750 Welch Road, Palo Alto, CA, 94304, USA., Wei Y; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Wen L; Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China., Srinivasan C; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Wolthers BO; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark., Tsai CY; Department of Pediatrics, Stanford University, 750 Welch Road, Palo Alto, CA, 94304, USA., Harris MH; Department of Pathology, Boston Children's Hospital, Boston, MA, USA., Stevenson K; Department of Data Sciences at Dana-Farber Cancer Institute, Boston, MA, USA., Byersdorfer C; Department of Pediatrics, Division of Blood and Marrow Transplant and Cellular Therapies, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Oparaji JA; Pediatrics, Guthrie Ambulatory Health Center, Fort Drum, NY, USA., Fernandez C; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA., Mukherjee A; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA., Abu-El-Haija M; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA., Agnihotri S; School of Medicine, Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Schmiegelow K; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark., Showalter MR; Metabolon, Inc., Durham, NC, USA., Fogle PW; Metabolon, Inc., Durham, NC, USA., McCulloch S; Metabolon, Inc., Durham, NC, USA., Contrepois K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA., Silverman LB; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA., Ding Y; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Husain SZ; Department of Pediatrics, Stanford University, 750 Welch Road, Palo Alto, CA, 94304, USA. sohail.husain@stanford.edu.

Publikováno v: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2021 Jun 27; Vol. 17 (7), pp. 64. Date of Electronic Publication: 2021 Jun 27.

Pharmacogenetics of the Central Nervous System-Toxicity and Relapse Affecting the CNS in Pediatric Acute Lymphoblastic Leukemia.

Autor: Sági JC; Department of Genetics, Cell and Immunobiology, Semmelweis University, H-1089 Budapest, Hungary., Gézsi A; Department of Measurement and Information Systems, Budapest University of Technology and Economics, H-1111 Budapest, Hungary.; MTA-SE Immune-Proteogenomics Extracellular Vesicle Research Group, Semmelweis University, H-1089 Budapest, Hungary., Egyed B; 2nd Department of Pediatrics, Semmelweis University, H-1094 Budapest, Hungary., Jakab Z; 2nd Department of Pediatrics, Semmelweis University, H-1094 Budapest, Hungary., Benedek N; Department of Pediatrics, Pécs University, H-7623 Pécs, Hungary., Attarbaschi A; Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, A-1090 Vienna, Austria., Köhrer S; Renate Panzer-Grümayer: Leukemia Biology Group, Children's Cancer Research Institute, A-1090 Vienna, Austria., Sipek J; Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, CZ-150 06 Prague, Czech Republic., Winkowska L; Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, CZ-150 06 Prague, Czech Republic.; CLIP-Childhood Leukemia Investigation Prague, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, CZ-150 06 Prague, Czech Republic., Zaliova M; Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, CZ-150 06 Prague, Czech Republic.; CLIP-Childhood Leukemia Investigation Prague, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, CZ-150 06 Prague, Czech Republic., Anastasopoulou S; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, S-17177 Stockholm, Sweden.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, S-14186 Stockholm, Sweden., Wolthers BO; Department of Paediatrics and Adolescent Medicine, Rigshospitalet, DK-2100 Copenhagen, Denmark., Ranta S; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, S-17177 Stockholm, Sweden.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, S-14186 Stockholm, Sweden., Szalai C; Department of Genetics, Cell and Immunobiology, Semmelweis University, H-1089 Budapest, Hungary.; Central Laboratory, Heim Pál Children's Hospital, H-1089 Budapest, Hungary., Kovács GT; 2nd Department of Pediatrics, Semmelweis University, H-1094 Budapest, Hungary., Semsei ÁF; Department of Genetics, Cell and Immunobiology, Semmelweis University, H-1089 Budapest, Hungary., Erdélyi DJ; 2nd Department of Pediatrics, Semmelweis University, H-1094 Budapest, Hungary.

Publikováno v: Cancers [Cancers (Basel)] 2021 May 12; Vol. 13 (10). Date of Electronic Publication: 2021 May 12.

Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia.

Autor: Tulstrup M; Department of Pediatrics and Adolescent Medicine and.; Department of Hematology, University Hospital Rigshospitalet, Copenhagen, Denmark., Moriyama T; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN., Jiang C; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University, Shanghai, China., Grosjean M; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark., Nersting J; Department of Pediatrics and Adolescent Medicine and., Abrahamsson J; Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Grell K; Section of Biostatistics, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hjalgrim LL; Department of Pediatrics and Adolescent Medicine and., Jónsson ÓG; Pediatric Hematology-Oncology, Barnaspitali Hringsins, Landspitali University Hospital, Reykjavik, Iceland., Kanerva J; Children's Hospital, Helsinki University Central Hospital, Helsinki, Finland., Lund B; Department of Pediatrics, St Olavs University Hospital, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Nielsen SN; Department of Pediatrics and Adolescent Medicine and., Nielsen RL; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing, China., Overgaard U; Department of Hematology, University Hospital Rigshospitalet, Copenhagen, Denmark., Quist-Paulsen P; Department of Hematology, St Olavs University Hospital, Trondheim, Norway., Pruunsild K; Department of Oncology and Haematology, Tallinn Children's Hospital, Tallinn, Estonia., Vaitkeviciene G; Centre for Paediatric Oncology and Haematology, Vilnius University Hospital Santaros Klinikos and Vilnius University, Vilnius, Lithuania., Wolthers BO; Department of Pediatrics and Adolescent Medicine and., Zhang H; Department of Pediatric Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China; and., Gupta R; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark., Yang JJ; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN., Schmiegelow K; Department of Pediatrics and Adolescent Medicine and.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Blood [Blood] 2020 Sep 03; Vol. 136 (10), pp. 1161-1168.