Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Wolter ten Hoeve"'
Autor:
Raffaella Rossin, Ron M. Versteegen, Jeremy Wu, Alisher Khasanov, Hans J. Wessels, Erik J. Steenbergen, Wolter ten Hoeve, Henk M. Janssen, Arthur H. A. M. van Onzen, Peter J. Hudson, Marc S. Robillard
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic ca
Externí odkaz:
https://doaj.org/article/b6e9e26c80024b1e84795b448f5f9b65
Autor:
Raffaella Rossin, Ron M. Versteegen, Jeremy Wu, Alisher Khasanov, Hans J. Wessels, Erik J. Steenbergen, Wolter ten Hoeve, Henk M. Janssen, Arthur H. A. M. van Onzen, Peter J. Hudson, Marc S. Robillard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article omitted the following from the Acknowledgements: ‘This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Breast Cancer Research Program under Award No. W81XWH
Externí odkaz:
https://doaj.org/article/fea92d6bbdb8481183adf2d4a9442582
Autor:
Bing Liu, Wolter ten Hoeve, Ron M Versteegen, Raffaella Rossin, Laurens HJ Kleijn, Marc S Robillard
Publikováno v:
Chemistry – A European Journal.
An increase of the click-to-release reaction rate between cleavable trans-cyclooctenes (TCO) and tetrazines would be beneficial for drug delivery applications. In this work, we developed a short and stereoselective synthesis route towards highly reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae3bb8156f4485efa6f4fbd10401928
https://doi.org/10.26434/chemrxiv-2022-xrq3p-v2
https://doi.org/10.26434/chemrxiv-2022-xrq3p-v2
Autor:
Jeremy Wu, Henk M. Janssen, Marc S. Robillard, Wolter ten Hoeve, Raffaella Rossin, Ivo A. W. Filot, Freek J. M. Hoeben, Tong Zhu, Ron M. Versteegen, Arthur H. A. M. van Onzen, Peter J. Hudson
Publikováno v:
Journal of the American Chemical Society, 142(25), 10955-10963. American Chemical Society
The high reaction rate of the 'click-to-release' reaction between allylic substituted trans-cyclooctene and tetrazine has enabled exceptional control over chemical and biological processes. Here we report the development of a new bioorthogonal cleava
Autor:
Sylvestre Bonnet, Dmitri V. Filippov, Sander I. van Kasteren, Jeroen D. C. Codée, Herman S. Overkleeft, Max S. Kloet, Kiki Kamphorst, Marc S. Robillard, Elmer Maurits, Mark A. R. de Geus, Andrea Pannwitz, Alexi J. C. Sarris, Wolter ten Hoeve, Thomas Hansen
Publikováno v:
de Geus, M A R, Maurits, E, Sarris, A J C, Hansen, T, Kloet, M S, Kamphorst, K, ten Hoeve, W, Robillard, M S, Pannwitz, A, Bonnet, S A, Codée, J D C, Filippov, D V, Overkleeft, H S & van Kasteren, S I 2020, ' Fluorogenic Bifunctional trans-Cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics ', Chemistry-A European Journal, vol. 26, no. 44, pp. 9900-9904 . https://doi.org/10.1002/chem.201905446
Chemistry-A European Journal, 26(44), 9900-9904. Wiley-VCH Verlag
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry – A European Journal
Chemistry-a European Journal, 26(44), 9900-9904
Chemistry-A European Journal, 26(44), 9900-9904. Wiley-VCH Verlag
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry – A European Journal
Chemistry-a European Journal, 26(44), 9900-9904
The inverse electron demand Diels–Alder pyridazine elimination reaction between tetrazines and allylic substituted trans‐cyclooctenes (TCOs) is a key player in bioorthogonal bond cleavage reactions. Determining the rate of elimination of alkylami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2934b0805fc36e3b284866a7c8515227
https://research.vu.nl/en/publications/c62a99a8-a2c4-41e0-8633-309843ad9529
https://research.vu.nl/en/publications/c62a99a8-a2c4-41e0-8633-309843ad9529
Autor:
Arthur H A M, van Onzen, Ron M, Versteegen, Freek J M, Hoeben, Ivo A W, Filot, Raffaella, Rossin, Tong, Zhu, Jeremy, Wu, Peter J, Hudson, Henk M, Janssen, Wolter, Ten Hoeve, Marc S, Robillard
Publikováno v:
Journal of the American Chemical Society. 142(25)
The high rate of the 'click-to-release' reaction between an allylic substituted
Autor:
Mark A. R. de Geus, Henk M. Janssen, Wolter ten Hoeve, Raffaella Rossin, Ron M. Versteegen, Marc S. Robillard
Publikováno v:
Angewandte Chemie-International Edition, 57(33), 10494-10499. Wiley
The bioorthogonal cleavage of allylic carbamates from trans-cyclooctene (TCO) upon reaction with tetrazine is widely used to release amines. We disclose herein that this reaction can also cleave TCO esters, carbonates, and surprisingly, ethers. Mecha
Autor:
Jeremy Wu, Alisher Khasanov, Peter J. Hudson, Ron M. Versteegen, Wolter ten Hoeve, Henk M. Janssen, Raffaella Rossin, Arthur H. A. M. van Onzen, Erik J. Steenbergen, Marc S. Robillard, Hans J. C. T. Wessels
Publikováno v:
Nature Communications, 9(1):1484. Nature Publishing Group
Nature Communications, 9, pp.
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9,
Nature Communications
Nature Communications, 9, pp.
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9,
Nature Communications
Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells leading to intracellular drug release. Typically, only a subset of patients with solid tumours has sufficient expression of such a receptor, while there are suitab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77b0775e4d21e2277afc8b9588b3e4a
https://research.tue.nl/nl/publications/e37d6b6f-65df-4929-8563-a399982085ef
https://research.tue.nl/nl/publications/e37d6b6f-65df-4929-8563-a399982085ef
Autor:
Sander M. J. van Duijnhoven, Marc S. Robillard, Laurens H. J. Kleijn, Freek J. M. Hoeben, Raffaella Rossin, Ron M. Versteegen, Wolter ten Hoeve, Henk M. Janssen
Publikováno v:
Bioconjugate Chemistry, 27(7), 1697-1706. American Chemical Society
The use of a bioorthogonal reaction for the selective cleavage of tumor-bound antibody-drug conjugates (ADCs) would represent a powerful new tool for ADC therapy, as it would not rely on the currently used intracellular biological activation mechanis