Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Wollman, Adam J. M."'
Autor:
Wareing, Thomas, Stokes, Alexander, Crompton, Katrina, Murphy, Koren, Dawson, Jack, Ugurluoglu, Yusuf Furkan, Richardson, Connor, Li, Hongquan, Prakash, Manu, Wollman, Adam J. M.
With the European Space Agency (ESA) and NASA working to return humans to the moon and onwards to Mars, it has never been more important to study the impact of altered gravity conditions on biological organisms. These include astronauts but also usef
Externí odkaz:
http://arxiv.org/abs/2406.09902
Autor:
Jin, Xin, Lee, Ji-Eun, Schaefer, Charley, Luo, Xinwei, Wollman, Adam J. M., Payne-Dwyer, Alex L., Tian, Tian, Zhang, Xiaowei, Chen, Xiao, Li, Yingxing, McLeish, Tom C. B., Leake, Mark C., Bai, Fan
Publikováno v:
Sci Adv. 2021 Oct 22;7(43):eabh2929
Liquid-liquid phase separation is emerging as a crucial phenomenon in several fundamental cell processes. A range of eukaryotic systems exhibit liquid condensates. However, their function in bacteria, which in general lack membrane-bound compartments
Externí odkaz:
http://arxiv.org/abs/2106.13148
As camera pixel arrays have grown larger and faster, and optical microscopy techniques ever more refined, there has been an explosion in the quantity of data acquired during routine light microcopy. At the single-molecule level, analysis involves mul
Externí odkaz:
http://arxiv.org/abs/2103.10164
Autor:
Wollman, Adam J. M, Syeda, Aisha H., Leech, Andrew, Guy, Colin, McGlynn, Peter, Hawkins, Michelle, Leake, Mark C.
DNA replication in all organisms must overcome nucleoprotein blocks to complete genome duplication. Accessory replicative helicases in Escherichia coli, Rep and UvrD, help replication machinery overcome blocks by removing incoming nucleoprotein compl
Externí odkaz:
http://arxiv.org/abs/2102.11266
Autor:
Miller, Helen L ., Contera, Sonia, Wollman, Adam J. M., Hirst, Adam, Dunn, Katherine E., Schroeter, Sandra, O'Connell, Deborah, Leake, Mark C.
Intercalation of drug molecules into synthetic DNA nanostructures formed through self-assembled origami has been postulated as a valuable future method for targeted drug delivery. This is due to the excellent biocompatibility of synthetic DNA nanostr
Externí odkaz:
http://arxiv.org/abs/1911.07022
Autor:
Stracy, Mathew, Wollman, Adam J. M., Kaja, Elzbieta, Gapinski, Jacek, Lee, Ji-Eun, Leek, Victoria A., McKie, Shannon J., Mitchenall, Lesley A., Maxwell, Anthony, Sherratt, David J., Leake, Mark C., Zawadzki, Pawel
Bacterial DNA gyrase introduces negative supercoils into chromosomal DNA and relaxes positive supercoils introduced by replication and transiently by transcription. Removal of these positive supercoils is essential for replication fork progression an
Externí odkaz:
http://arxiv.org/abs/1811.00531
Single-molecule biophysics has transformed our understanding of the fundamental molecular processes involved in living biological systems, but also of the fascinating physics of life. Far more exotic than a collection of exemplars of soft matter beha
Externí odkaz:
http://arxiv.org/abs/1704.06837
Autor:
Wollman, Adam J. M., Shashkova, Sviatlana, Hedlund, Erik G., Friemann, Rosmarie, Hohmann, Stefan, Leake, Mark C.
Transcription is regulated through binding factors to gene promoters to activate or repress expression, however, the mechanisms by which factors find targets remain unclear. Using single-molecule fluorescence microscopy, we determined in vivo stoichi
Externí odkaz:
http://arxiv.org/abs/1704.02513
Staphylococcus aureus is an important pathogen, giving rise to antimicrobial resistance in cell strains such as Methicillin Resistant S. aureus (MRSA). Here we report an image analysis framework for automated detection and image segmentation of cells
Externí odkaz:
http://arxiv.org/abs/1610.06361
Antibiotics such as the quinolones and fluoroquinolones kill bacterial pathogens ultimately through DNA damage. They target the essential type IIA topoisomerases in bacteria by stabilising the normally transient double strand break state which is cre
Externí odkaz:
http://arxiv.org/abs/1605.07789