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Akademický článek

Quantitative Measurement of Rate of Targeted Protein Degradation.

Autor: Lynch TL 4th; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Marin VL; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., McClure RA; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Phipps C; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Ronau JA; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Rouhimoghadam M; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Adams AM; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Kandi S; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Wolke ML; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Shergalis AG; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Potts GK; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Nacham O; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Richardson P; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Kakavas SJ; Target Enabling Technologies, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Chhor G; Target Enabling Technologies, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Jenkins GJ; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Woller KR; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Warder SE; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Vasudevan A; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Reitsma JM; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2024 Jul 19; Vol. 19 (7), pp. 1604-1615. Date of Electronic Publication: 2024 Jul 09.

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Akademický článek

CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16.

Autor: Shergalis AG; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Marin VL; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Rhee DY; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Senaweera S; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., McCloud RL; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Ronau JA; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Hutchins CW; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., McLoughlin S; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Woller KR; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Warder SE; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Vasudevan A; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States., Reitsma JM; Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2023 Feb 17; Vol. 18 (2), pp. 331-339. Date of Electronic Publication: 2023 Jan 19.

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Akademický článek

Targeting IRAK3 for Degradation to Enhance IL-12 Pro-inflammatory Cytokine Production.

Autor: Rowley A; Drug Discovery Science & Technology, AbbVie Inc., North Chicago, Illinois 60064, United States., Brown BS; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Stofega M; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Hoh H; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Mathew R; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Marin V; Drug Discovery Science & Technology, AbbVie Inc., North Chicago, Illinois 60064, United States., Ding RX; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., McClure RA; Drug Discovery Science & Technology, AbbVie Inc., North Chicago, Illinois 60064, United States., Bittencourt FM; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Chen J; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Gururaja T; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Kinoshita T; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Wang X; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Rivkin A; Oncology Discovery, AbbVie Inc., South San Francisco, California 94080, United States., Woller KR; Drug Discovery Science & Technology, AbbVie Inc., North Chicago, Illinois 60064, United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2022 Jun 17; Vol. 17 (6), pp. 1315-1320. Date of Electronic Publication: 2022 May 17.

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