Strategies for developing retinoic acid receptor alpha-selective antagonists as novel agents for male contraception.

Autor: Al Noman MA; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Cuellar RAD; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Kyzer JL; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Chung SSW; Department of Genetics and Development, USA., Cheryala N; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Holth TAD; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Maitra S; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Naqvi T; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Wong HL; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Schönbrunn E; Department of Drug Discovery, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL, 33612, USA., Hawkinson JE; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA., Wolgemuth DJ; Department of Genetics and Development, USA; Department of Obstetrics and Gynecology, USA; The Institute of Human Nutrition, USA; The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1150 St. Nicholas Avenue, New York, NY, 10032, USA., Georg GI; Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA. Electronic address: georg@umn.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 05; Vol. 261, pp. 115821. Date of Electronic Publication: 2023 Sep 25.

Genome-wide chromatin occupancy of BRDT and gene expression analysis suggest transcriptional partners and specific epigenetic landscapes that regulate gene expression during spermatogenesis.

Autor: Her YR; Department of Genetics & Development, Columbia University Medical Center, New York, New York, USA., Wang L; Department of Genetics & Development, Columbia University Medical Center, New York, New York, USA., Chepelev I; Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Manterola M; Human Genetics Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile., Berkovits B; Department of Genetics & Development, Columbia University Medical Center, New York, New York, USA., Cui K; Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Zhao K; Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Wolgemuth DJ; Department of Genetics & Development, Columbia University Medical Center, New York, New York, USA.; Department Obstetrics & Gynecology, Columbia University Medical Center, New York, New York, USA.; Institute of Human Nutrition, Columbia University Medical Center, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA.

Publikováno v: Molecular reproduction and development [Mol Reprod Dev] 2021 Feb; Vol. 88 (2), pp. 141-157. Date of Electronic Publication: 2021 Jan 20.

Filamentous actin disorganization and absence of apical ectoplasmic specialization disassembly during spermiation upon interference with retinoid signaling†.

Autor: Chung SSW; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA., Vizcarra N; The Institute of Human Nutrition Columbia University Irving Medical Center, New York, NY, USA., Wolgemuth DJ; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.; The Institute of Human Nutrition Columbia University Irving Medical Center, New York, NY, USA.; The Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.

Publikováno v: Biology of reproduction [Biol Reprod] 2020 Aug 04; Vol. 103 (2), pp. 378-389.

Genetic etiological spectrum of sperm morphological abnormalities.

Autor: Arora M; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India., Mehta P; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Sethi S; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Anifandis G; Department of Obstetrics and Gynaecology, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larisa, Greece., Samara M; Department of Obstetrics and Gynaecology, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larisa, Greece., Singh R; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India. rajender_singh@cdri.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. rajender_singh@cdri.res.in.

Publikováno v: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.

Exploring the molecular mechanism of ginseng against anthracycline-induced cardiotoxicity based on network pharmacology, molecular docking and molecular dynamics simulation.

Autor: Xie, Lin¹ (AUTHOR), Liu, Hanze² (AUTHOR), Zhang, Ke² (AUTHOR), Pan, Yijun² (AUTHOR), Chen, Mengyao¹ (AUTHOR), Xue, Xiangyue¹ (AUTHOR), Wan, Guoxing² (AUTHOR) 15gxwan@stu.edu.cn

Publikováno v: Hereditas. 9/6/2024, Vol. 161 Issue 1, p1-16. 16p.