Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Wolfram-Hubertus Zimmermann"'
Autor:
Alexandra Viktoria Busley, Óscar Gutiérrez-Gutiérrez, Elke Hammer, Fabian Koitka, Amin Mirzaiebadizi, Martin Steinegger, Constantin Pape, Linda Böhmer, Henning Schroeder, Mandy Kleinsorge, Melanie Engler, Ion Cristian Cirstea, Lothar Gremer, Dieter Willbold, Janine Altmüller, Felix Marbach, Gerd Hasenfuss, Wolfram-Hubertus Zimmermann, Mohammad Reza Ahmadian, Bernd Wollnik, Lukas Cyganek
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114448- (2024)
Summary: Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset hypertrophic cardiomyopathy. In this study, we investigate the mechanistic consequences of a homozygous variant LZTR1L5
Externí odkaz:
https://doaj.org/article/199d047ff2b846ddbbff360254a381ed
Autor:
Kea Aline Schmoll, Thomas Mager, Timothy Pok-man Tse, Ahmed Alameldeen, Wolfram-Hubertus Zimmermann, Maria-Patapia Zafeiriou
Publikováno v:
Stem Cell Research, Vol 75, Iss , Pp 103317- (2024)
Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy. To investigate neuronal connectivity with other excitable cells we established an optog
Externí odkaz:
https://doaj.org/article/00c19728b4f34f57847662fe058056d7
Autor:
Mina Shahriyari, Malte Rinn, Arne D. Hofemeier, Artem Babych, Wolfram-Hubertus Zimmermann, Malte Tiburcy
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102794- (2024)
Summary: Force generation is an essential property of skeletal muscle models in vitro. We describe a versatile 1-step procedure to direct undifferentiated human pluripotent stem cells (PSCs) into contractile skeletal muscle organoids (SMOs). Our prot
Externí odkaz:
https://doaj.org/article/06f22c7c00d744fbb6e0c75ce4b356e0
Autor:
Mina Shahriyari, Md Rezaul Islam, Sadman M. Sakib, Malte Rinn, Anastasia Rika, Dennis Krüger, Lalit Kaurani, Verena Gisa, Mandy Winterhoff, Harithaa Anandakumar, Orr Shomroni, Matthias Schmidt, Gabriela Salinas, Andreas Unger, Wolfgang A. Linke, Jana Zschüntzsch, Jens Schmidt, Rhonda Bassel‐Duby, Eric N. Olson, André Fischer, Wolfram‐Hubertus Zimmermann, Malte Tiburcy
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 6, Pp 3106-3121 (2022)
Abstract Background Human pluripotent stem cell‐derived muscle models show great potential for translational research. Here, we describe developmentally inspired methods for the derivation of skeletal muscle cells and their utility in skeletal musc
Externí odkaz:
https://doaj.org/article/1634c6c809c344e3adcd3f61bb3b0fea
Autor:
Amir Moussavi, Sophie Mißbach, Claudia Serrano Ferrel, Hasti Ghasemipour, Kristin Kötz, Charis Drummer, Rüdiger Behr, Wolfram-Hubertus Zimmermann, Susann Boretius
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cardiac MRI in rhesus macaques, a species of major relevance for preclinical studies on biological therapies, requires artificial ventilation to realize breath holding. To overcome this limitation of standard cine MRI, the feasibility of Rea
Externí odkaz:
https://doaj.org/article/17149159db284b80ae2d6aa5055bdcb7
Autor:
Md Rezaul Islam, Lalit Kaurani, Tea Berulava, Urs Heilbronner, Monika Budde, Tonatiuh Pena Centeno, Vakthang Elerdashvili, Maria‐Patapia Zafieriou, Eva Benito, Sinem M Sertel, Maria Goldberg, Fanny Senner, Janos L Kalman, Susanne Burkhardt, Anne Sophie Oepen, Mohammad Sadman Sakib, Cemil Kerimoglu, Oliver Wirths, Heike Bickeböller, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Nicoleta‐Carmen Cosma, Klaus Fliessbach, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Luca Kleinedam, Christoph Laske, Coraline D Metzger, Matthias H Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris S. Rauchmann, Nina Roy, Anja Schneider, Annika Spottke, Eike J Spruth, Stefan Teipel, Maike Tscheuschler, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Delcode Study Group, Silvio O Rizzoli, Wolfram‐Hubertus Zimmermann, Thomas G Schulze, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced s
Externí odkaz:
https://doaj.org/article/1e2ab5f4a61e40db8cbade9a85f5dc94
Autor:
Maria-Patapia Zafeiriou, Guobin Bao, James Hudson, Rashi Halder, Alica Blenkle, Marie-Kristin Schreiber, Andre Fischer, Detlev Schild, Wolfram-Hubertus Zimmermann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Brain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation wit
Externí odkaz:
https://doaj.org/article/f2273b0bcbe64fb79978e872f203e52e
Autor:
Malte Tiburcy, Alex Markov, Lena K. Kraemer, Peter Christalla, Margret Rave‐Fraenk, Henrike J. Fischer, Holger M. Reichardt, Wolfram‐Hubertus Zimmermann
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 12, Pp 731-746 (2019)
Abstract Satellite cells reside in defined niches and are activated upon skeletal muscle injury to facilitate regeneration. Mechanistic studies of skeletal muscle regeneration are hampered by the inability to faithfully simulate satellite cell biolog
Externí odkaz:
https://doaj.org/article/7b9d3c00f09b42efb6f04603c7aa7345
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102518- (2021)
CRISPR/Cas9 technology based on nuclease inactive dCas9 and fused to the heterotrimeric VPR transcriptional activator is a powerful tool to enhance endogenous transcription by targeting defined genomic loci. We generated homozygous human induced plur
Externí odkaz:
https://doaj.org/article/f1fdd96aa6904e23a011a83992e16b54
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102473- (2021)
Using nuclease-deficient dead (d)Cas9 without enzymatic activity fused to transcriptional inhibitors (CRISPRi) allows for transcriptional interference and results in a powerful tool for the elucidation of developmental, homeostatic and disease mechan
Externí odkaz:
https://doaj.org/article/282da98ef9ad44eba03661fa85efe8dd