Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Wolfram Föllmann"'
Publikováno v:
Archives of Toxicology. 88:1097-1107
Citrinin (CIT) and ochratoxin A (OTA) are mycotoxins produced by several species of the genera Aspergillus, Penicillium and Monascus. Both can be present as contaminants in various food commodities and in animal feed. The occurrence and toxicity of O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1160c3780dea4540a9fb563eec0652
https://doi.org/10.1007/s00204-014-1216-8
https://doi.org/10.1007/s00204-014-1216-8
Publikováno v:
Journal of toxicology and environmental health. Part A. 79(22-23)
Contamination of grains with mycotoxins results in a dietary background exposure of the general population. In occupational settings such as during processing of raw materials as in milling, an additional mycotoxin exposure by inhalation is possible.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed440ce94f1bc1cdbafe0b00f0a8208e
https://pubmed.ncbi.nlm.nih.gov/27924714
https://pubmed.ncbi.nlm.nih.gov/27924714
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 75:1206-1215
N-Acetyltransferases (NAT) are important enzymes in the metabolism of certain carcinogenic arylamines, as N-acetylation decreases or prevents their bioactivation via N-hydroxylation. To study such processes in the bladder, cell culture models may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf541e95b248f0c0fd4a5c3208fc652d
https://doi.org/10.1080/15287394.2012.709167
https://doi.org/10.1080/15287394.2012.709167
Autor:
Sabine Plöttner, Jan G. Hengstler, Gisela H. Degen, Silvia Selinski, Wolfram Föllmann, Peter H. Roos, Hermann M. Bolt
Publikováno v:
Archives of Toxicology. 83:131-138
Cultured primary porcine urinary bladder epithelial cells (PUBEC) represent an adequate and easy to handle in vitro system for studies of urothelial toxicity. PUBEC maintain in vivo-like metabolic activities and physiological functions. They express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758e584d2b927014d31e3d9a1c307c58
https://doi.org/10.1007/s00204-008-0329-3
https://doi.org/10.1007/s00204-008-0329-3
Autor:
Alexander Wolf, Sabine Plöttner, Jürgen Kuhlmann, Hermann M. Bolt, Alexandra Borza, Wolfram Föllmann
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 71:969-975
Exposure to tobacco smoke is an established cause of cancer in humans and cigarette smoking is a risk factor for urinary bladder cancer development. Aromatic amines are believed responsible for the bladder-specific carcinogenic effect, but polycyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3c05c4b2a6df7079e9b5fb64cb14b5
https://doi.org/10.1080/15287390801989184
https://doi.org/10.1080/15287390801989184
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 71:930-935
A cell culture system with human-derived urothelial cells was established based upon previous experience with cultures of porcine urinary bladder epithelial cells. Human tissue specimens used were derived from urinary bladders (n = 17) or ureters (n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bf2f626a978d3431b2b04954e27791
https://doi.org/10.1080/15287390801988939
https://doi.org/10.1080/15287390801988939
Publikováno v:
Toxicology. 224:81-90
The mycotoxin ochratoxin A (OTA) is a worldwide contaminant of human food. OTA is genotoxic, immunotoxic, teratogenic and carcinogenic in rodents and can cause nephropathy in pigs. High amounts of OTA can cause nephropathy in humans. Moreover, eviden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3789137bfc86f9f42287764ef1609c9
https://doi.org/10.1016/j.tox.2006.04.034
https://doi.org/10.1016/j.tox.2006.04.034
Autor:
Stefan Lebrun, Wolfram Föllmann
Publikováno v:
Mycotoxin Research. 21:53-56
The mycotoxin ochratoxin A (OTA) induced DNA strand breaks in porcine urinary bladder epithelial cells (PUBEC) and in Madin Darby canine kidney (MDCK) cells. A co-incubation with bile acids or methotrexate reduced or even prevented this adverse effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8cebfa5b9e59c7e97ddc7a53601479
https://doi.org/10.1007/bf02954818
https://doi.org/10.1007/bf02954818
Publikováno v:
Alternatives to Laboratory Animals. 32:555-571
Epithelial crypts from the bovine colon were obtained by using a combined mechanical and enzymatic isolation method, followed by differential D-sorbitol gradient centrifugation. By using this isolation technique, a pure fraction of epithelial crypts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d3ddb1ab05370158d6d39052823765
https://doi.org/10.1177/026119290403200607
https://doi.org/10.1177/026119290403200607
Publikováno v:
Archives of Toxicology. 77:621-629
The metabolic competence of cultured bovine colon epithelial cells was evaluated by determining activities of phase I and II enzymes in colonocytes cultured for different intervals (maximum of 10 days) compared with activities measured in freshly iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c7cf648c0ec865017985d1878a8eca
https://doi.org/10.1007/s00204-003-0490-7
https://doi.org/10.1007/s00204-003-0490-7