The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines.

Autor: Wildenberg ME; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands., Koelink PJ; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands., Diederen K; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands., Te Velde AA; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands., Wolfkamp SC; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands., Nuij VJ; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands., Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands., Nobis M; Beatson Institute for Cancer Research, Bearsden, Glasgow, UK., Sansom OJ; Beatson Institute for Cancer Research, Bearsden, Glasgow, UK., Anderson KI; Beatson Institute for Cancer Research, Bearsden, Glasgow, UK., van der Woude CJ; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands., D'Haens GR; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands., van den Brink GR; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2017 Mar; Vol. 10 (2), pp. 352-360. Date of Electronic Publication: 2016 Jul 20.

ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients.

Autor: Wolfkamp SC; Simone CS Wolfkamp, Caroline Verseyden, Esther WM Vogels, Sander Meisner, Charlotte P Peters, Anje A te Velde, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands., Verseyden C; Simone CS Wolfkamp, Caroline Verseyden, Esther WM Vogels, Sander Meisner, Charlotte P Peters, Anje A te Velde, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands., Vogels EW; Simone CS Wolfkamp, Caroline Verseyden, Esther WM Vogels, Sander Meisner, Charlotte P Peters, Anje A te Velde, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands., Meisner S; Simone CS Wolfkamp, Caroline Verseyden, Esther WM Vogels, Sander Meisner, Charlotte P Peters, Anje A te Velde, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands., Boonstra K; Simone CS Wolfkamp, Caroline Verseyden, Esther WM Vogels, Sander Meisner, Charlotte P Peters, Anje A te Velde, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands., Peters CP; Simone CS Wolfkamp, Caroline Verseyden, Esther WM Vogels, Sander Meisner, Charlotte P Peters, Anje A te Velde, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands., Stokkers PC; Simone CS Wolfkamp, Caroline Verseyden, Esther WM Vogels, Sander Meisner, Charlotte P Peters, Anje A te Velde, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands., te Velde AA; Simone CS Wolfkamp, Caroline Verseyden, Esther WM Vogels, Sander Meisner, Charlotte P Peters, Anje A te Velde, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands.

Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2014 Mar 14; Vol. 20 (10), pp. 2664-72.

Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse.

Autor: Wildenberg ME; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Vos AC, Wolfkamp SC, Duijvestein M, Verhaar AP, Te Velde AA, van den Brink GR, Hommes DW

Publikováno v: Gastroenterology [Gastroenterology] 2012 Jun; Vol. 142 (7), pp. 1493-503.e6. Date of Electronic Publication: 2012 Feb 24.

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.

Autor: Weersma RK; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, the Netherlands. R.K.Weersma@int.umcg.nl, Stokkers PC, Cleynen I, Wolfkamp SC, Henckaerts L, Schreiber S, Dijkstra G, Franke A, Nolte IM, Rutgeerts P, Wijmenga C, Vermeire S

Publikováno v: The American journal of gastroenterology [Am J Gastroenterol] 2009 Mar; Vol. 104 (3), pp. 630-8. Date of Electronic Publication: 2009 Jan 27.