Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wolfgang-Alexander Simon"'
Autor:
Werner Hartwig, Wolfgang Alexander Simon, Thilo Hackert, Klaus Felix, Dmitry Dovshanskiy, Stefan Tudor, Jens Werner
Publikováno v:
Life Sciences. 87:551-557
Aims Oxidative stress with free radicals plays a crucial role in acute pancreatitis (AP). Pantoprazole (PPZ), widely used as a proton pump inhibitor, possesses reactivity towards hydroxyl radicals. The aim of the study was to examine the effect of PP
Autor:
Jürgen Volz, Anja Schmid, Peter Jan Zimmermann, Andreas Palmer, Stefan Postius, Christof Brehm, Dietmar Hess, Wolfgang Kromer, Burkhard Grobbel, Gabriela Münch, Wolfgang-Alexander Simon, Wilm Buhr, Vittoria Chiesa
Publikováno v:
Journal of Medicinal Chemistry. 53:3645-3674
Potassium-competitive acid blockers (P-CABs) constitute a new therapeutic option for the treatment of acid-related diseases that are widespread and constitute a significant economical burden. Enantiomerically pure tetrahydrochromenoimidazoles were pr
Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase
Autor:
Wolfgang-Alexander Simon, Peter Jan Zimmermann, Wilm Buhr, Christof Brehm, Jürgen Volz, Andreas Palmer
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:536-541
A series of novel 6-substituted imidazo[1,2-a]pyrazines were synthesized via palladium catalyzed amino- or alkoxycarbonylation as key step. The anti-secretory activity of these compounds has been assessed in a binding assay against H+/K+-ATPase from
Autor:
Michael Herrmann, Reinhard Huber, Stefan Postius, Jörg Senn-Bilfinger, Wolfgang Alexander Simon, Jai M Shin, Thomas W. Klein
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:866-874
After treatment of millions of patients suffering from gastroesophageal reflux disease (GERD) and other acid-related ailments with proton pump inhibitors, there are still unmet medical needs such as rapid and reliable pain relief, especially for noct
Autor:
Christof Brehm, Gabriela Münch, Sandra Chrismann, Martin Feth, Peter Jan Zimmermann, Andreas Palmer, Wilm Buhr, Jörg Senn-Bilfinger, Wolfgang Alexander Simon
Publikováno v:
Bioorganicmedicinal chemistry. 17(1)
Asymmetric and symmetric spiro(imidazo[1,2- a ]pyrano[2,3- c ]pyridine-9-indenes) were prepared using a synthetic approach that comprised a cross-metathesis reaction and an acid-catalyzed cycloisomerisation as key steps. The target compounds constitu
Autor:
Martin Feth, Wolfgang-Alexander Simon, Joerg Senn-Bilfinger, Christof Brehm, Peter Jan Zimmermann, Andreas Palmer, Wilm Buhr
Publikováno v:
ChemInform. 39
A series of novel 8-indanylamino- and 8-indanyloxy-substituted imidazo[1,2- a ]pyridines with reduced lipophilicity was synthesized from easily accessible starting compounds. The anti-secretory activity of these compounds has been assessed in a compe
Autor:
Wolfgang Kromer, Wilm Buhr, Andreas Palmer, Peter Jan Zimmermann, Burkhard Grobbel, Cornelia Jecke, Wolfgang-Alexander Simon, Christof Brehm, Martin Feth
Publikováno v:
Journal of medicinal chemistry. 50(24)
7H-8,9-Dihydropyrano[2,3-c]imidazo[1,2-a]pyridines with excellent physicochemical and pharmacological properties were identified that represent interesting candidates for further development as potassium-competitive acid blockers (P-CABs). The title
Autor:
Wilm Buhr, Hans Christof Holst, Wolfgang Alexander Simon, Andreas Palmer, Burkhard Grobbel, Christof Brehm, Martin Feth, Peter Jan Zimmermann
Publikováno v:
Bioorganicmedicinal chemistry. 15(24)
A series of novel tetrahydroimidazo[2,1- a ]isoquinolines was prepared based on a hetero Diels–Alder reaction between an enamine and 1,2,4-triazine as key step. A structure–activity relationship was established focussing on the influence of the s
Autor:
Christof Brehm, Wolfgang Alexander Simon, Peter Jan Zimmermann, Wilm Buhr, Martin Feth, Andreas Palmer, Gabriela Münch
Publikováno v:
Bioorganicmedicinal chemistry. 16(3)
A series of novel 1H-pyrrolo[3,2-b]pyridines was prepared relying on a copper iodide catalyzed cyclization of 2-prop-1-ynylpyridin-3-amines. A structure-activity relationship was established focusing on the influence of the substitution pattern in po
Publikováno v:
The FASEB Journal. 20