Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Wolfgang Wiegrebe"'
Autor:
Wolfgang Wiegrebe
Publikováno v:
Theology and Science. 17:455-468
Due to his Muslim belief, D.A.-F. Batchelor wants to confirm and harmonize the Qur’anic reports of the origin of Adam and Eve with paleolithic and embryological statements. Batchelor quite often ci...
Publikováno v:
Journal of Mass Spectrometry. 40:1309-1318
Fumaric acid esters, namely dimethylfumarate, have been used for the treatment of psoriasis for many years. Still, their mode of action is not fully clear. Because addition of nucleophiles to the double bonds of fumarates can occur (Michael analogous
Autor:
Wolfgang Wiegrebe, David Jirovsky
Publikováno v:
Monatshefte f�r Chemie/Chemical Monthly. 135:1563-1568
Simple isocratic HPLC systems without tedious purification steps are elaborated for analyses of fumaric acid, its dimethyl and monomethyl ester, useful for analyses in biological matrices.
Autor:
Wolfgang Wiegrebe, Masataka Moriyasu, Kinuko Iwasa, Makiko Sugiura, Dong-Ung Lee, Ayako Kuribayashi
Publikováno v:
Phytochemistry. 64:1229-1238
The metabolism of 2,3,10,11-oxygenated protoberberine alkaloids was studied in cell cultures of Corydalis species. Without prior isolation, the structures of the metabolites were determined by LC-MS and LC-NMR analyses. Tetrahydropseudocoptisine alph
Autor:
Wolfgang Wiegrebe, Manuela Pillinger, Robert Loewe, Ulrich Mrowietz, Peter Petzelbauer, Klaus Wolff, Wolfgang Holnthoner, David Jirovsky, Rainer de Martin, Marion Gröger
Publikováno v:
Journal of Investigative Dermatology. 117:1363-1368
Fumaric acid esters are thought to improve psoriasis by altering leukocyte, keratinocyte, and/or endothelial functions. To determine specificity, kinetics, and molecular mechanisms of different fumaric acid esters in their ability to inhibit endothel
Publikováno v:
Monatshefte fuer Chemie/Chemical Monthly. 132:765-768
The absolute configuration of the centre of asymmetry in the side chain of the alkaloid vincetene (1) was determined by ozonolysis and subsequent unequivocal transformations affording the (S)-enantiomer of 1,2-propanediyl dibenzoate (4).
Publikováno v:
Journal of Natural Products. 61:1150-1153
The 8-alkyl- (3−6), 8-phenyl- (7), 12-bromo- (8), 8-alkyl-12-bromo- (9−12), and 12-bromo-8-phenyl- (13) berberine derivatives were prepared and tested for their antimicrobial activity in vitro to evaluate structure−activity relationships. Intro
Publikováno v:
Monatshefte f�r Chemie Chemical Monthly. 128:1247-1254
Highly diastereoselective BH3/THF syn-reduction of the 3-hydroxy-1,3-diphenylpropan-1-one/BBr3 complex3/BBr3 (cf.Sarko) afforded themeso-diol4, whereas racemate5 was obtained by BH3/THF reduction without complexation. Mesylation, exchange of mesylate
Autor:
Wolfgang Wiegrebe, E. Grün
Publikováno v:
Monatshefte f�r Chemie Chemical Monthly. 128:1033-1049
The title compounds (5) were prepared by addition of 2-phenyl-1,3-dithiane anion (2-lithiated10) to adequately substituted N-alkyl-3,4-dihydroisoquinolinium salts (7a–7g). Cleavage of compounds5 with HgO/BF3 affords S-benzoyl-1,3-propanedithiol (4a
Publikováno v:
Monatshefte f�r Chemie Chemical Monthly. 128:659-673
N-Butoxy- and N-propoxy-imines derived fromo-,m-, andp-substituted benzaldehydes (X = F, Cl, Br, I) decompose upon electron impact to the respective aldoximes by loss of C n H2n and competitivelyvia 1,5-distonic radical cations by loss of CH2O to 1,3