Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Wolfgang W Wicha"'
Autor:
Michael Hafner, Susanne Paukner, Wolfgang W Wicha, Boška Hrvačić, Matea Cedilak, Ivan Faraho, Steven P Gelone
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0237659 (2021)
Several antibiotics demonstrate both antibacterial and anti-inflammatory/immunomodulatory activities and are used to treat inflammatory pulmonary disorders. Lefamulin is a pleuromutilin antibiotic approved to treat community-acquired bacterial pneumo
Externí odkaz:
https://doaj.org/article/136f83670bc14055ac4e6c2288b6710a
Autor:
Susanne Paukner, Sandra Kimber, Charlotte Cumper, Tina Rea-Davies, Lorena Sueiro Ballesteros, Christopher Kirkham, Adam Hargreaves, Steven P. Gelone, Claire Richards, Wolfgang W. Wicha
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5401 (2024)
Lefamulin is a first-in-class systemic pleuromutilin antimicrobial and potent inhibitor of bacterial translation, and the most recent novel antimicrobial approved for the treatment of community-acquired pneumonia (CAP). It exhibits potent antibacteri
Externí odkaz:
https://doaj.org/article/465c8dafc02148c7bdc3396a19a8661a
Autor:
Susanne Jacobsson, Daniel Golparian, Joakim Oxelbark, Wolfgang W. Wicha, Renata Maria Augusto da Costa, Francois Franceschi, David Brown, Arnold Louie, Steven P. Gelone, George Drusano, Magnus Unemo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is seriously threatening the treatment and control of gonorrhea globally. Novel treatment options are essential, coupled with appropriate methods to pharmacodynamically exa
Externí odkaz:
https://doaj.org/article/765f6e4bb4ca4554b2fdda59a5a0e418
Autor:
Wolfgang W Wicha, Sandy Kimber, Charlotte Cumper, Hon S Lam, Lorena S Ballesteros, Christopher Kirkham, Claire Richards, Steven P Gelone, Susanne Paukner
Publikováno v:
Open Forum Infectious Diseases. 9
Background Lefamulin (LEF) is a pleuromutilin antibiotic approved by the United States (US) FDA for the treatment of community-acquired bacterial pneumonia in adults. In addition to the potent antibacterial activity, LEF has demonstrated anti-inflamm
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Lefamulin, a semisynthetic pleuromutilin antibiotic approved in the United States, Canada, and Europe for intravenous and oral treatment of community-acquired bacterial pneumonia, is highly active in vitro against bacterial pathogens that cause sexua
Publikováno v:
Antimicrobial agents and chemotherapy. 66(8)
Lefamulin, a semisynthetic pleuromutilin antibiotic approved in the United States, Canada, and Europe for intravenous and oral treatment of community-acquired bacterial pneumonia, is highly active
Autor:
Steven P Gelone, Cathie Leister, James A. Dowell, Thomas Marbury, Wolfgang W Wicha, Jared L. Crandon, James Ermer
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 41:451-456
STUDY OBJECTIVE Lefamulin is a novel IV and oral pleuromutilin recently approved for the treatment of community-acquired bacterial pneumonia (CABP). Given that renal comorbidities are common in patients admitted for CABP, understanding the pharmacoki
Autor:
Thomas Marbury, Steven P Gelone, Cathie Leister, Wolfgang W Wicha, James Ermer, James A. Dowell, Jared L. Crandon
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 41:457-462
Study objective Lefamulin is a novel pleuromutilin recently approved by the FDA for the treatment of community-acquired bacterial pneumonia. Given that lefamulin is primarily metabolized by CYP450 Phase-1 reactions, this study evaluated the pharmacok
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives To present results of preclinical studies that supported further development of lefamulin for treating patients with community-acquired bacterial pneumonia (CABP). Methods The effect of bovine lung surfactant on the antibacterial activity
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives To explore the pharmacokinetics (PK) of oral and intravenous (iv) lefamulin after single and multiple doses, and the effect of food on bioavailability. Methods Lefamulin PK was examined in four studies. In Study 1, PK was assessed in patie