Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Wolfgang Sommergruber"'
Autor:
Sarang S. Talwelkar, Mikko I. Mäyränpää, Julia Schüler, Nora Linnavirta, Annabrita Hemmes, Simone Adinolfi, Matti Kankainen, Wolfgang Sommergruber, Anna‐Liisa Levonen, Jari Räsänen, Aija Knuuttila, Emmy W. Verschuren, Krister Wennerberg
Publikováno v:
Molecular Oncology, Vol 17, Iss 5, Pp 747-764 (2023)
Treatment with anaplastic lymphoma kinase (ALK) inhibitors significantly improves outcome for non‐small‐cell lung cancer (NSCLC) patients with ALK‐rearranged tumors. However, clinical resistance typically develops over time and, in the majority
Externí odkaz:
https://doaj.org/article/1563d14766b740a0a1ffecc8176e6bc3
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4be66cd1e91343128ab75e66caed6e3b
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/9a2b99b0e13748afb59d9e2a0782fdda
Autor:
Jesse J. Lipp, Limei Wang, Haitang Yang, Feng Yao, Nathalie Harrer, Stefan Müller, Sabina Berezowska, Patrick Dorn, Thomas M. Marti, Ralph A. Schmid, Belazs Hegedüs, Abdallah Souabni, Sebastian Carotta, Mark A. Pearson, Wolfgang Sommergruber, Greg J. Kocher, Sean R.R. Hall
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Antibody-mediated cancer immunotherapy targets inhibitory surface molecules, such as PD1, PD-L1, and CTLA-4, aiming to re-invigorate dysfunctional T cells. We purified and characterized tumor-infiltrating lymphocytes (TILs) and their patient-matched
Externí odkaz:
https://doaj.org/article/9667d060bac747349286c601bb989662
Autor:
Limei Wang, Haitang Yang, Patrick Dorn, Sabina Berezowska, Fabian Blank, Carlos Wotzkow, Thomas M. Marti, Ren-Wang Peng, Nathalie Harrer, Wolfgang Sommergruber, Gregor J. Kocher, Ralph A. Schmid, Sean R.R. Hall
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103664- (2021)
Summary: Background: Although T cell abundance in solid tumours is associated with better outcomes, it also correlates with a stroma-mediated source of immune suppression driven by TGFβ1 and poor overall survival. Whether this also is observed in no
Externí odkaz:
https://doaj.org/article/1f7d51f1822442cc8888fbc4d5daa6bb
Autor:
Tobias Gluexam, Alexander M. Grandits, Angela Schlerka, Chi Huu Nguyen, Julia Etzler, Thomas Finkes, Michael Fuchs, Christoph Scheid, Gerwin Heller, Hubert Hackl, Nathalie Harrer, Heinz Sill, Elisabeth Koller, Dagmar Stoiber, Wolfgang Sommergruber, Rotraud Wieser
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 23, p 5826 (2019)
The neuropeptide CGRP, acting through the G-protein coupled receptor CALCRL and its coreceptor RAMP1, plays a key role in migraines, which has led to the clinical development of several inhibitory compounds. Recently, high CALCRL expression has been
Externí odkaz:
https://doaj.org/article/b708c3a7892a46e39842864b4b51203d
Autor:
Julia Schueler, Cordula Tschuch, Kerstin Klingner, Daniel Bug, Anne-Lise Peille, Leanne de Koning, Eva Oswald, Hagen Klett, Wolfgang Sommergruber
Publikováno v:
Cells, Vol 8, Iss 7, p 740 (2019)
In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor receptor (EGFR). Although these patients gain great benefit from treatment with EGFR tyrosine kina
Externí odkaz:
https://doaj.org/article/60af5e27fd674a39be230ddc5b6944c8
Autor:
Albin Rudisch, Matthew Richard Dewhurst, Luminita Gabriela Horga, Nina Kramer, Nathalie Harrer, Meng Dong, Heiko van der Kuip, Andreas Wernitznig, Andreas Bernthaler, Helmut Dolznig, Wolfgang Sommergruber
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124283 (2015)
We established co-cultures of invasive or non-invasive NSCLC cell lines and various types of fibroblasts (FBs) to more precisely characterize the molecular mechanism of tumor-stroma crosstalk in lung cancer. The HGF-MET-ERK1/2-CREB-axis was shown to
Externí odkaz:
https://doaj.org/article/1cd708db78024fd595c13cbe9731f2c4
Autor:
Wolfgang Sommergruber, Michael Freissmuth, Christina Glöckel, Simon Keuerleber, Tilman Voss, Stefan Kastner
PDF file - 62K, Gpr19 siRNA-induced increase in the relative number of DMS 53 cells with G2/M DNA content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cccdafb01f64a90a75b0db3123094e0
https://doi.org/10.1158/1541-7786.22517430.v1
https://doi.org/10.1158/1541-7786.22517430.v1
Autor:
Wolfgang Sommergruber, Michael Freissmuth, Christina Glöckel, Simon Keuerleber, Tilman Voss, Stefan Kastner
PDF file - 51K, Detailed cell line information for human NSCLC, SCLC, and normal lung cell lines and HEK-293 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e854bf5a69b761df23e9b90d888487e
https://doi.org/10.1158/1541-7786.22517421.v1
https://doi.org/10.1158/1541-7786.22517421.v1