Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Wolfgang Siess"'
Publikováno v:
Platelets, Vol 31, Iss 8, Pp 989-992 (2020)
Externí odkaz:
https://doaj.org/article/d273fc43a5224e1daf74524af4f523e4
Autor:
Luise Goldmann, Rundan Duan, Thorsten Kragh, Georg Wittmann, Christian Weber, Reinhard Lorenz, Philipp von Hundelshausen, Michael Spannagl, Wolfgang Siess
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 4021-4033 (2019)
Abstract: Activation of the platelet Fc-receptor CD32a (FcγRIIA) is an early and crucial step in the pathogenesis of heparin-induced thrombocytopenia type II (HIT) that has not been therapeutically targeted. Downstream FcγRIIA Bruton tyrosine kinas
Externí odkaz:
https://doaj.org/article/2d9e7772bfc94b21ac3710a27736c30e
Autor:
Rundan Duan, Luise Goldmann, Richard Brandl, Michael Spannagl, Christian Weber, Wolfgang Siess, Philipp von Hundelshausen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Bruton tyrosine kinase inhibitors (BTKi) are used in B-cell malignancies and in development against various autoimmune diseases. Since Btk is also involved in specific pathways of platelet activation, BTKi might be considered to target pl
Externí odkaz:
https://doaj.org/article/ac46e632b236415080f63ae9ae03dce7
Autor:
Rundan Duan, Luise Goldmann, Ya Li, Christian Weber, Wolfgang Siess, Philipp von Hundelshausen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 76 (2021)
High platelet reactivity leading to spontaneous platelet aggregation (SPA) is a hallmark of cardiovascular diseases; however, the mechanism underlying SPA remains obscure. Platelet aggregation in stirred hirudin-anticoagulated blood was measured by m
Externí odkaz:
https://doaj.org/article/8a4a561365d44e6285091227a864a859
Publikováno v:
Cancers, Vol 13, Iss 5, p 1103 (2021)
Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes, myeloid cells and platelets, and Btk-inhibitors (BTKi) are used to treat patients with B-cell malignancies, developed against autoimmune diseases, have been proposed as novel antithrombotic
Externí odkaz:
https://doaj.org/article/7b78d6f4e5b34a079fbd82f269032ee7
Autor:
Janina Jamasbi, RPh, Remco T.A. Megens, PhD, Mariaelvy Bianchini, MSc, Kerstin Uhland, PhD, Götz Münch, MD, Martin Ungerer, MD, Shachar Sherman, BSc, Alexander Faussner, PhD, Richard Brandl, MD, Christine John, MSc, Johannes Buchner, PhD, Christian Weber, MD, Reinhard Lorenz, MD, Natalie Elia, PhD, Wolfgang Siess, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 3, Pp 131-142 (2016)
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc. Cross-linking potentiated the inhibition of
Externí odkaz:
https://doaj.org/article/61bf0fc198ea4ad180b532af81574356
Autor:
Heidrun Degen, Oliver Borst, Melanie Ziegler, Ann‐Katrin Mojica Munoz, Janina Jamasbi, Britta Walker, Silvia Göbel, Julia Fassbender, Kristin Adler, Richard Brandl, Götz Münch, Reinhard Lorenz, Wolfgang Siess, Meinrad Gawaz, Martin Ungerer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)
BackgroundGPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies. GPVI‐Fc is
Externí odkaz:
https://doaj.org/article/8c41f738c98d45e59044b26e25dfec32
Autor:
Pankaj Goyal, Dharmendra Pandey, Daniela Brünnert, Elke Hammer, Marek Zygmunt, Wolfgang Siess
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71769 (2013)
BACKGROUND: ADF/cofilin proteins are key regulators of actin dynamics. Their function is inhibited by LIMK-mediated phosphorylation at Ser-3. Previous in vitro studies have shown that dependent on its concentration, cofilin either depolymerizes F-act
Externí odkaz:
https://doaj.org/article/54d60e18cdb3453083d76f33b12a3225
Autor:
Roghieh Djafarzadeh, Matthias Sauter, Susan Notohamiprodjo, Elfriede Noessner, Pankaj Goyal, Wolfgang Siess, Markus Wörnle, Andrea Ribeiro, Susanne Himmelein, Thomas Sitter, Peter J Nelson
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e33963 (2012)
BACKGROUND: Mesothelial cells are critical in the pathogenesis of post-surgical intraabdominal adhesions as well as in the deterioration of the peritoneal membrane associated with long-term peritoneal dialysis. Mesothelial denudation is a pathophysio
Externí odkaz:
https://doaj.org/article/51b1158abb4c4732b2bb821836577d50
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16249 (2011)
BackgroundMigration and proliferation of vascular endothelial cells are essential for repair of injured endothelium and angiogenesis. Cyclins, cyclin-dependent kinases (CDKs), and cyclin-dependent kinase inhibitors play an important role in vascular
Externí odkaz:
https://doaj.org/article/57fa8748e35e4781aa02bc2fb9c8e108