Zobrazeno 1 - 10
of 345
pro vyhledávání: '"Wolfgang Sadee"'
Autor:
Wolfgang Sadee
Publikováno v:
Molecules, Vol 28, Iss 17, p 6375 (2023)
G-protein-coupled receptors (GPCRs) are ubiquitous sensors and regulators of cellular functions. Each GPCR exists in complex aggregates with multiple resting and active conformations. Designed to detect weak stimuli, GPCRs can also activate spontaneo
Externí odkaz:
https://doaj.org/article/54a30b8d9d3f4f7b990b64319e79cc96
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0244904 (2022)
Genome-wide association studies (GWAS) have implicated 58 loci in coronary artery disease (CAD). However, the biological basis for these associations, the relevant genes, and causative variants often remain uncertain. Since the vast majority of GWAS
Externí odkaz:
https://doaj.org/article/4129a4d53ce14357a192d4a7210b4e8d
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3061 (2022)
CYP3A4, CYP3A5, and CYP3A7, which are located in a multigene locus (CYP3A), play crucial roles in drug metabolism. To understand the highly variable hepatic expression of CYP3As, regulatory network analyses have focused on transcription factors (TFs)
Externí odkaz:
https://doaj.org/article/6e118bd529ef422a9563721d21d42c50
Autor:
Wolfgang Sadee, John C. McKew
Publikováno v:
Molecules, Vol 27, Iss 18, p 5826 (2022)
Numerous G-protein-coupled receptors (GPCRs) display ligand-free basal signaling with potential physiological functions, a target in drug development. As an example, the μ opioid receptor (MOR) signals in ligand-free form (MOR-μ*), influencing opio
Externí odkaz:
https://doaj.org/article/bcffa2743a434c83bbc0c79f572c25cb
Autor:
Alireza Safa, Allison R. Lau, Sydney Aten, Karl Schilling, Karen L. Bales, Victoria A. Miller, Julie Fitzgerald, Min Chen, Kasey Hill, Kyle Dzwigalski, Karl Obrietan, Mitch A. Phelps, Wolfgang Sadee, John Oberdick
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Newborns exposed to prenatal opioids often experience intense postnatal withdrawal after cessation of the opioid, called neonatal opioid withdrawal syndrome (NOWS), with limited pre- and postnatal therapeutic options available. In a prior study in pr
Externí odkaz:
https://doaj.org/article/8682fde484134ec2b6aa095fb25e2262
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Universal approaches to the prevention and treatment of human diseases fail to take into account profound immune diversity resulting from genetic variations across populations. Personalized or precision medicine takes into account individual lifestyl
Externí odkaz:
https://doaj.org/article/13bcd386a1b546559d35bb1f5a3d9bab
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background The CHRNA5/A3/B4 gene locus is associated with nicotine dependence and other smoking related disorders. While the non-synonymous CHRNA5 variant rs16969968 appears to be the main risk factor, linkage disequilibrium (LD) bins in the
Externí odkaz:
https://doaj.org/article/5cf37496322e4304a90906c57c7df4c5
Autor:
Ana Caroline C. Sá, Amy Webb, Yan Gong, Caitrin W. McDonough, Mohamed H. Shahin, Somnath Datta, Taimour Y. Langaee, Stephen T. Turner, Amber L. Beitelshees, Arlene B. Chapman, Eric Boerwinkle, John G. Gums, Steven E. Scherer, Rhonda M. Cooper-DeHoff, Wolfgang Sadee, Julie A. Johnson
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Background Recently, 34 genes had been associated with differential expression relative to blood pressure (BP)/ hypertension (HTN). We hypothesize that some of the genes associated with BP/HTN are also associated with BP response to antihype
Externí odkaz:
https://doaj.org/article/0e2dbd26f75946c0b4dacc18b645c125
Publikováno v:
Molecules, Vol 25, Iss 18, p 4163 (2020)
Opioid analgesics are effective pain therapeutics but they cause various adverse effects and addiction. For safer pain therapy, biased opioid agonists selectively target distinct μ opioid receptor (MOR) conformations, while the potential of biased o
Externí odkaz:
https://doaj.org/article/387ba014962c4f7baa5b747018107f26
Autor:
Audrey C Papp, Abul K Azad, Maciej Pietrzak, Amanda Williams, Samuel K Handelman, Robert P Igo, Catherine M Stein, Katherine Hartmann, Larry S Schlesinger, Wolfgang Sadee
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198221 (2018)
Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood monocyte-derived macrophages (MDM) are a model for investigating M.tb-macrophage interactions.
Externí odkaz:
https://doaj.org/article/e28290c5f68e46aa883fa2d95c42d8e0