Synthesis of Polyethylenimine-Based Nanocarriers for Systemic Tumor Targeting of Nucleic Acids

Autor: Wolfgang, Rödl, Alexander, Taschauer, David, Schaffert, Ernst, Wagner, Manfred, Ogris

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1943

Nucleic acid-based therapies offer the option to treat tumors in a highly selective way, while toxicity towards healthy tissue can be avoided when proper delivery vehicles are used. We have recently developed carrier systems based on linear polyethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98e0acd13fe67e02cfc85a66c45d9e6e
https://pubmed.ncbi.nlm.nih.gov/30838611

Novel PAMAM-PEG-Peptide Conjugates for siRNA Delivery Targeted to the Transferrin and Epidermal Growth Factor Receptors

Autor: Koldo Urbiola, Laura Blanco-Fernandez, Ernst Wagner, Wolfgang Rödl, Conchita Tros de Ilarduya, Manfred Ogris

Publikováno v: Journal of Personalized Medicine; Volume 8; Issue 1; Pages: 4
Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 8, Iss 1, p 4 (2018)
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname

The transferrin (TfR) and epidermal growth factor receptors (EGFR) are known to be overexpressed on the surface of a wide variety of tumor cells. Therefore, the peptides B6 (TfR specific) and GE11 (targeted to the EGFR) were linked to the PAMAM (poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f125fb5ad006633ecbfc40f7097d1ee

Toward Artificial Immunotoxins: Traceless Reversible Conjugation of RNase A with Receptor Targeting and Endosomal Escape Domains

Autor: Xiaowen Liu, Ulrich Lächelt, Wolfgang Rödl, Ernst Wagner, Kevin Maier, Peng Zhang

Publikováno v: Molecular pharmaceutics. 14(5)

The specific transport of bioactive proteins into designated target cells is an interesting and challenging perspective for the generation of innovative biopharmaceuticals. Natural protein cytotoxins perform this task with outstanding efficacy. They

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd823106dcfb740ae4902d242890e68d
https://pubmed.ncbi.nlm.nih.gov/28457141

Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes

Autor: Franz-Josef Gildehaus, Stephan Morys, Nathalie Schwenk, Kathrin Klutz, Geoffrey K. Grünwald, Christian Zach, Sarah Urnauer, Christine Spitzweg, Ernst Wagner, Wolfgang Rödl, Manfred Ogris

Publikováno v: The journal of gene medicine. 19(5)

Background Non-viral polymer-based gene transfer represents an adaptable system for tumor-targeted gene therapy, as various design strategies of shuttle systems together with the mechanistic concept of active tumor targeting lead to improved gene del

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8b135171e093dc93a41ba79dba7b47
https://pubmed.ncbi.nlm.nih.gov/28423213

Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nanocore with an Influenza Peptide and Transferrin Shell

Autor: Wolfgang Rödl, Eva Kessel, Wei Zhang, Katharina Müller, Ernst Wagner, Sören Reinhard, Philipp M. Klein, Dongsheng He, Susanne Kempter, Miriam Höhn

Publikováno v: Advanced healthcare materials. 5(12)

Developing RNA-interference-based therapeutic approaches with efficient and targeted cytosolic delivery of small interfering RNA (siRNA) is remaining a critical challenge since two decades. Herein, a multifunctional transferrin receptor (TfR)-targete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1169abbf90e759b32adeff76d0efa9f
https://pubmed.ncbi.nlm.nih.gov/27109317