Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wolfgang P. Ruf"'
Autor:
Sarah J. Brockmann, Eva Buck, Tiziana Casoli, João L. Meirelles, Wolfgang P. Ruf, Paolo Fabbietti, Karlheinz Holzmann, Jochen H. Weishaupt, Albert C. Ludolph, Fiorenzo Conti, Karin M. Danzer
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-13 (2023)
Abstract Background ALS is a heterogeneous disease in which different factors such as mitochondrial phenotypes act in combination with a genetic predisposition. This study addresses the question of whether homoplasmic (total mitochondrial genome of a
Externí odkaz:
https://doaj.org/article/5c05a220789c40f78e5b3a267fbf6094
Autor:
Divisha Bhatia, Veselin Grozdanov, Wolfgang P. Ruf, Jan Kassubek, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-10 (2021)
Abstract The dysregulation of peripheral immunity in Parkinson’s Disease (PD) includes changes in both the relative numbers and gene expression of T cells. The presence of peripheral T-cell abnormalities in PD is well-documented, but less is known
Externí odkaz:
https://doaj.org/article/1d5acbd09239467db660ff01bd6c3da2
Autor:
Wolfgang P. Ruf, Annette Palmer, Lena Dörfer, Diana Wiesner, Eva Buck, Veselin Grozdanov, Jan Kassubek, Leda Dimou, Albert C. Ludolph, Markus Huber-Lang, Karin M. Danzer
Publikováno v:
Neurobiology of Disease, Vol 174, Iss , Pp 105877- (2022)
Background: Systemic and neuroinflammatory processes play key roles in neurodegenerative diseases such as Parkinson's disease (PD). Physical trauma which induces considerable systemic inflammatory responses, represents an evident environmental factor
Externí odkaz:
https://doaj.org/article/630a3504cc4f4361a4b215a42fb6b6a1
Autor:
Wolfgang P. Ruf, Axel Freischmidt, Veselin Grozdanov, Valerie Roth, Sarah J. Brockmann, Brit Mollenhauer, Dorothea Martin, Bernhard Haslinger, Katrin Fundel-Clemens, Markus Otto, Christine von Arnim, Karlheinz Holzmann, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer
Publikováno v:
Cells, Vol 10, Iss 4, p 791 (2021)
Accumulating evidence suggests that microRNAs (miRNAs) are a contributing factor to neurodegenerative diseases. Although altered miRNA profiles in serum or plasma have been reported for several neurodegenerative diseases, little is known about the in
Externí odkaz:
https://doaj.org/article/808a1008cd304e32a6a70f47921e6f17
Autor:
Eva Buck, Patrick Oeckl, Veselin Grozdanov, Verena Bopp, Julia K. Kühlwein, Wolfgang P. Ruf, Diana Wiesner, Francesco Roselli, Jochen H. Weishaupt, Albert C. Ludolph, Markus Otto, Karin M. Danzer
Publikováno v:
Acta neuropathologica 144, 161-164 (2022). doi:10.1007/s00401-022-02436-1
Elevated levels of neurofilament light chain (NF-L) in CSF and blood are linked to the presymptomatic and symptomatic phase of patients suffering from amyotrophic lateral sclerosis (ALS). However, whether the NF-L level in extracellular liquids like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8997bd2e2b3925f840985f4c95041ffa
https://doi.org/10.1007/s00401-022-02436-1
https://doi.org/10.1007/s00401-022-02436-1
Autor:
Volkan Yazar, Wolfgang P Ruf, Antje Knehr, Kornelia Günther, Ole Ammerpohl, Karin M Danzer, Albert C Ludolph
Publikováno v:
Epigenetics Insights 16, 251686572311721 (2023). doi:10.1177/25168657231172159
ALS is a fatal motor neuron disease that displays a broad variety of phenotypes ranging from early fatal courses to slowly progressing and rather benign courses. Such divergence can also be seen in genetic ALS cases with varying phenotypes bearing sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10d28baf65e6f70afa59fe39534a61c
https://pub.dzne.de/record/257896
https://pub.dzne.de/record/257896
Autor:
Julia K. Kühlwein, Wolfgang P. Ruf, Katharina Kandler, Simon Witzel, Christina Lang, Medhanie A. Mulaw, Arif B. Ekici, Jochen H. Weishaupt, Albert C. Ludolph, Veselin Grozdanov, Karin M. Danzer
Publikováno v:
Cellular and molecular life sciences 80(5), 131 (2023). doi:10.1007/s00018-023-04769-w
Amyotrophic Lateral Sclerosis (ALS) is a complex and incurable neurodegenerative disorder in which genetic and epigenetic factors contribute to the pathogenesis of all forms of ALS. The interplay of genetic predisposition and environmental footprints
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf37cb9a91825213956de9823b54d4e
Autor:
Wolfgang P Ruf, Matej Boros, Axel Freischmidt, David Brenner, Veselin Grozdanov, Joao de Meirelles, Thomas Meyer, Torsten Grehl, Susanne Petri, Julian Grosskreutz, Ute Weyen, Rene Guenther, Martin Regensburger, Tim Hagenacker, Jan C Koch, Alexander Emmer, Annekathrin Roediger, Robert Steinbach, Joachim Wolf, Jochen H Weishaupt, Paul Lingor, Marcus Deschauer, Isabell Cordts, Thomas Klopstock, Peter Reilich, Florian Schoeberl, Berthold Schrank, Daniel Zeller, Andreas Hermann, Antje Knehr, Kornelia Günther, Johannes Dorst, Joachim Schuster, Reiner Siebert, Albert C Ludolph, Kathrin Müller
Publikováno v:
Brain communications 5(3), fcad152 (2023). doi:10.1093/braincomms/fcad152
Therapy of motoneuron diseases entered a new phase with the use of intrathecal antisense oligonucleotide therapies treating patients with specific gene mutations predominantly in the context of familial amyotrophic lateral sclerosis. With the majorit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d627c9995e02867199c28235efea107c
https://doi.org/10.1093/braincomms/fcad152
https://doi.org/10.1093/braincomms/fcad152
Autor:
Wolfgang P. Ruf, Eilis Hannon, Axel Freischmidt, Veselin Grozdanov, David Brenner, Kathrin Müller, Antje Knehr, Kornelia Günther, Johannes Dorst, Ole Ammerpohl, Karin M. Danzer, Jonathan Mill, Albert C. Ludolph, Jochen H. Weishaupt
Publikováno v:
Neurobiology of aging 116, 16-24 (2022). doi:10.1016/j.neurobiolaging.2022.04.003
Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron disease with a monogenic cause in approximately 10% of cases. However, familial clustering of disease without inheritance in a Mendelian manner and the broad range of phenotypes suggest the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731bec5247b1a186568f0b0830f5ecc9
https://pub.dzne.de/record/164043
https://pub.dzne.de/record/164043
Autor:
Eva, Buck, Patrick, Oeckl, Veselin, Grozdanov, Verena, Bopp, Julia K, Kühlwein, Wolfgang P, Ruf, Diana, Wiesner, Francesco, Roselli, Jochen H, Weishaupt, Albert C, Ludolph, Markus, Otto, Karin M, Danzer
Publikováno v:
Acta neuropathologica. 144(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4f293458a0cda9d6326e934c1338f7d
https://pubmed.ncbi.nlm.nih.gov/35585288
https://pubmed.ncbi.nlm.nih.gov/35585288