Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Wolfgang Link"'
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-16 (2023)
Abstract FOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell maintenance, cancer, metabolic, and cardiovascular diseases. Genetic evidence has been accu
Externí odkaz:
https://doaj.org/article/da7ab7b3c62142029d99db813f088275
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/3fa3a99cc0c147c0af4ddaa68c8527fa
Autor:
Guillermo Velasco, Wolfgang Link
Publikováno v:
Cancers, Vol 15, Iss 14, p 3547 (2023)
The human kinome comprises 518 protein kinases, of which approximately 10% lack one or more of the conserved amino acids necessary for catalytic activity [...]
Externí odkaz:
https://doaj.org/article/6d82e30bce0c4b129d7bb5619b17bec5
Autor:
Richard Hill, Patricia A. Madureira, Bibiana Ferreira, Inês Baptista, Susana Machado, Laura Colaҫo, Marta dos Santos, Ningshu Liu, Ana Dopazo, Selma Ugurel, Angyal Adrienn, Endre Kiss-Toth, Murat Isbilen, Ali O. Gure, Wolfgang Link
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/09cb3cdd535740fb87f2aab84021359e
Autor:
Mónica T. Fernandes, Victor Yassuda, José Bragança, Wolfgang Link, Bibiana I. Ferreira, Ana Luísa De Sousa-Coelho
Publikováno v:
Gastrointestinal Disorders, Vol 3, Iss 4, Pp 218-236 (2021)
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death due to cancer in the world. Therefore, the identification of novel druggable targets is urgently needed. Tribbles proteins belong to a pseudokinase family,
Externí odkaz:
https://doaj.org/article/4b7eddd73718442fb80be4be470c2766
Autor:
Winda Puspitasari, Björn Allemann, Deepti Angra, Helen Appleyard, Wolfgang Ecke, Christian Möllers, Tanja Nolte, Randy W. Purves, Carsten Renner, Thomas Robertson-Shersby-Harvie, Rebecca Tacke, Alex Windhorst, Sonja Yaman, Wolfgang Link
Publikováno v:
Journal für Kulturpflanzen, Vol 74, Iss 01-02 (2022)
GWAS was applied to the antinutritive compounds vicine and convicine (V, C) in winter faba bean. V, C and V + C data for 189 inbred lines (five environments) were predicted by NIRS. These lines do not carry the strong “vc-“ allele (locus VC1). La
Externí odkaz:
https://doaj.org/article/0368c83f34fd4d15a6914ed1db882a90
Conventional and Molecular Breeding Tools for Accelerating Genetic Gain in Faba Bean (Vicia Faba L.)
Autor:
Kedar N. Adhikari, Hamid Khazaei, Lamiae Ghaouti, Fouad Maalouf, Albert Vandenberg, Wolfgang Link, Donal M. O'Sullivan
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Faba bean is a cool-season grain legume crop, which is grown worldwide for food and feed. Despite a decrease in area under faba bean in the past, the interest in growing faba bean is increasing globally due to its high seed protein content and its ex
Externí odkaz:
https://doaj.org/article/367ad5679a4e410abffa73911cda054f
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/21f9778fdf524eff9dd1685c3def184b
Autor:
Lucia Jimenez, Carlos Amenabar, Victor Mayoral-Varo, Thomas A. Mackenzie, Maria C. Ramos, Andreia Silva, Giampaolo Calissi, Inês Grenho, Carmen Blanco-Aparicio, Joaquin Pastor, Diego Megías, Bibiana I. Ferreira, Wolfgang Link
Publikováno v:
Molecules, Vol 27, Iss 17, p 5414 (2022)
Forkhead box O (FOXO) proteins are transcription factors involved in cancer and aging and their pharmacological manipulation could be beneficial for the treatment of cancer and healthy aging. FOXO proteins are mainly regulated by post-translational m
Externí odkaz:
https://doaj.org/article/9157ca9e965549dbb2537e2f37cd8973
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The transport through the nuclear pore complex is used by cancer cells to evade tumor-suppressive mechanisms. Several tumor-suppressors have been shown to be excluded from the cell nucleus in cancer cells by the nuclear export receptor CRM1 and abnor
Externí odkaz:
https://doaj.org/article/1a21fad76e624e2098953984b01ecb98