Zobrazeno 1 - 10
of 423
pro vyhledávání: '"Wolfgang Holzer"'
Autor:
Massimo Carraro, Camillo Are, Ugo Azzena, Lidia De Luca, Silvia Gaspa, Giuseppe Satta, Wolfgang Holzer, Vittorio Pace, Luisa Pisano
Publikováno v:
Molecules, Vol 29, Iss 8, p 1714 (2024)
Aryl and heteroaryl iodides have been efficiently converted into the corresponding thioacetates in cyclopentyl methyl ether (CPME), a green solvent, under Cu catalysis. The chemoselectivity of the reaction is mainly controlled by electronic factors,
Externí odkaz:
https://doaj.org/article/79673f593bc04fb6b912642908b3d0de
Autor:
Marius Ozenil, Lukas Skos, Alexander Roller, Natalie Gajic, Wolfgang Holzer, Helmut Spreitzer, Sonja Platzer-Ozenil, Chrysoula Vraka, Marcus Hacker, Wolfgang Wadsak, Verena Pichler
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Pharmacovigilance aims at a better understanding of the molecular events triggered by medications to prevent adverse effects, which despite significant advances in our analytical repertoire plague the use of drugs until today. In this study,
Externí odkaz:
https://doaj.org/article/af7948b51c254a38a9f2d2f540fc8bd3
Autor:
Vaida Milišiūnaitė, Rūta Paulavičiūtė, Eglė Arbačiauskienė, Vytas Martynaitis, Wolfgang Holzer, Algirdas Šačkus
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 679-684 (2019)
Fused pyrazole ring systems are common structural motifs of numerous pharmaceutically important compounds. Nevertheless, access to derivatives of the aromatic 2H-furo[2,3-c]pyrazole ring system is still quite limited, and their chemistry and function
Externí odkaz:
https://doaj.org/article/c31b2b962c4a4b2796a51b4c0f682e37
Autor:
Jonas Kilian, Marlon Millard, Marius Ozenil, Dominik Krause, Khadija Ghaderi, Wolfgang Holzer, Ernst Urban, Helmut Spreitzer, Wolfgang Wadsak, Marcus Hacker, Thierry Langer, Verena Pichler
Publikováno v:
Molecules, Vol 27, Iss 10, p 3173 (2022)
The muscarinic acetylcholine receptor family is a highly sought-after target in drug and molecular imaging discovery efforts aimed at neurological disorders. Hampered by the structural similarity of the five subtypes’ orthosteric binding pockets, t
Externí odkaz:
https://doaj.org/article/d52eff788f3b4aaf997cff8fa33f468d
Autor:
Jonas Kilian, Marius Ozenil, Marlon Millard, Dorka Fürtös, Verena Maisetschläger, Wolfgang Holzer, Wolfgang Wadsak, Marcus Hacker, Thierry Langer, Verena Pichler
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 248 (2022)
Due to their important role in mediating a broad range of physiological functions, muscarinic acetylcholine receptors (mAChRs) have been a promising target for therapeutic and diagnostic applications alike; however, the list of truly subtype-selectiv
Externí odkaz:
https://doaj.org/article/c79cce6a7452410e9132bd5fcc90b670
Publikováno v:
ARKIVOC, Vol 2018, Iss 5, Pp 296-307 (2018)
Externí odkaz:
https://doaj.org/article/4ac2dcb082484247981cd6a8f4c5f24c
Autor:
Gernot A. Eller, Gytė Vilkauskaitė, Algirdas Šačkus, Vytas Martynaitis, Ashenafi Damtew Mamuye, Vittorio Pace, Wolfgang Holzer
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1287-1292 (2018)
Dialkyl 5,5'-dioxo-4,4'-bipyrazole-4,4'-dicarboxylates are readily obtained by the reaction of 5-hydroxypyrazole-4-carboxylates in refluxing thionyl chloride. The obtained diesters can be transformed into the corresponding 4,4'-bipyrazoles via alkali
Externí odkaz:
https://doaj.org/article/e12202150669428fa6a67465407b6b4e
Autor:
Josef Jansa, Ramona Schmidt, Ashenafi Damtew Mamuye, Laura Castoldi, Alexander Roller, Vittorio Pace, Wolfgang Holzer
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 895-902 (2017)
A synthesis of tetrasubstituted pyrazoles containing two, three or four pyridinyl substituents is described. Hence, the reaction of 1,3-dipyridinyl-1,3-propanediones with 2-hydrazinopyridine or phenylhydrazine, respectively, affords the corresponding
Externí odkaz:
https://doaj.org/article/4a612a253f9d4e4d826f56f43c5d5cfe
Autor:
Marius Ozenil, Jonas Aronow, Daniela Piljak, Chrysoula Vraka, Wolfgang Holzer, Helmut Spreitzer, Wolfgang Wadsak, Marcus Hacker, Verena Pichler
Publikováno v:
Pharmaceuticals, Vol 13, Iss 12, p 437 (2020)
Muscarinic acetylcholine receptors (mAChRs) are a pivotal constituent of the central and peripheral nervous system. Yet, therapeutic and diagnostic applications thereof are hampered by the lack of subtype selective ligands. Within this work, we synth
Externí odkaz:
https://doaj.org/article/2aaf6b887f474a00bcc6dc8cdb5afa8e
Autor:
Catharina Neudorfer, Amir Seddik, Karem Shanab, Andreas Jurik, Christina Rami-Mark, Wolfgang Holzer, Gerhard Ecker, Markus Mitterhauser, Wolfgang Wadsak, Helmut Spreitzer
Publikováno v:
Molecules, Vol 20, Iss 1, Pp 1712-1730 (2015)
Since the norepinephrine transporter (NET) is involved in a variety of diseases, the investigation of underlying dysregulation-mechanisms of the norepinephrine (NE) system is of major interest. Based on the previously described highly potent and sele
Externí odkaz:
https://doaj.org/article/71c75aa91bd045bc9b0891a23d84ac36