Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wolfgang Holla"'
Publikováno v:
ARKIVOC, Vol 2012, Iss 3, Pp 257-278 (2012)
Externí odkaz:
https://doaj.org/article/35845550351f4fc99e5ae1e74dae5bd6
Autor:
Jens Atzrodt, Friedemann Schmidt, Kerstin Wäse, Jacquelyn Dwyer, Wolfgang Holla, Martina Dorau, Alexander Amberg, Volker Derdau, József Pánczél, Angela Dudda, Ulrich Kürzel, Dietmar Weitz, Elisabeth Defossa, Catherine Arabeyre, Markus Kohlmann, Timothy Ackerson, Jens Riedel, Thomas Kissner, Shibani Rajanna
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 33
For fasiglifam (TAK875) and its metabolites the substance-specific mechanisms of liver toxicity were studied. Metabolism studies were run to identify a putatively reactive acyl glucuronide metabolite. In vitro cytotoxicity and caspase 3/7 activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f2228bb7b27785702d8052feb6867b
https://doi.org/10.1002/jbt.22345
https://doi.org/10.1002/jbt.22345
Autor:
Glenn Gröbe, Martin Sandvoss, Martin Hofrichter, Wolfgang Holla, Marzena Poraj-Kobielska, Jens Atzrodt, Katrin Scheibner
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 56:513-519
Enzymatic conversion of a drug can be an efficient alternative for the preparation of a complex metabolite compared with a multi-step chemical synthesis approach. Limitations exist for chemical methods for direct oxygen incorporation into organic mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d01adfc1410359f394c73424f2f8c60f
https://doi.org/10.1002/jlcr.3103
https://doi.org/10.1002/jlcr.3103
Autor:
Jens Atzrodt, Lorenz Neubert, Sebastian Imm, Wolfgang Holla, Matthias Beller, Volker Derdau, Helfried Neumann, Sebastian Bähn, Dirk Michalik
Publikováno v:
Journal of the American Chemical Society. 134:12239-12244
A novel and convenient protocol for the catalytic hydrogen-deuterium exchange of biologically active tertiary amines utilizing the borrowing hydrogen methodology has been developed. In the presence of the readily available Shvo catalyst, excellent ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787558f9a5a200c25d838692f0453e54
https://doi.org/10.1021/ja3041338
https://doi.org/10.1021/ja3041338
Publikováno v:
ARKIVOC, Vol 2012, Iss 3, Pp 257-278 (2012)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9df3e4ecc67d5f02e8be3fc78e8009a
https://doi.org/10.3998/ark.5550190.0013.319
https://doi.org/10.3998/ark.5550190.0013.319
Autor:
Stephan Enthaler, Udo Kragl, Daniel Schichl, Thomas Dr. Riermeier, Wolfgang Holla, Matthias Beller
Publikováno v:
European Journal of Organic Chemistry. 2008:3506-3512
A convenient procedure for the racemization of α-amino acid esters in the presence of catalytic amounts of salicylaldehydes is described. The combination of this racemization protocol with lipase-catalyzed ester hydrolysis allows successful dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8363ce94374fc9b019362fd07141cc3
https://doi.org/10.1002/ejoc.200800253
https://doi.org/10.1002/ejoc.200800253
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:295-299
A safe, user friendly and efficient method to provide high deuterium incorporation into a variety of organic substrates was developed. Systematic screening of catalysts and activators revealed that the activation of the Pd- or Rh-catalyst by NaBD 4 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad2a4968b77a1417ff0760651db33e23
https://doi.org/10.1002/jlcr.1209
https://doi.org/10.1002/jlcr.1209
Autor:
Glenn Gröbe, Marzena Poraj-Kobielska, Katrin Scheibner, Johannes Heidrich, Wolfgang Holla, Reiner Simonis, Martin Hofrichter, Jens Atzrodt, Jan Kiebist, Martin Sandvoss
Publikováno v:
Bioorganicmedicinal chemistry. 23(15)
Unspecific peroxygenases (UPOs, EC 1.11.2.1) have proved to be stable oxygen-transferring biocatalysts for H2O2-dependent transformation of pharmaceuticals. We have applied UPOs in a drug development program and consider the enzymatic approach in par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6a8b096827dd70dfa37792f7de8f73
https://pubmed.ncbi.nlm.nih.gov/26142319
https://pubmed.ncbi.nlm.nih.gov/26142319
Publikováno v:
The Journal of Organic Chemistry. 63:5658-5661
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::561f1978e4183186370211f245295b2a
https://doi.org/10.1021/jo980174n
https://doi.org/10.1021/jo980174n
Autor:
Matthias Beller, Bernd Napierski, E. Wolfgang Holla, Holger Geissler, Markus Eckert, Heinz-Peter Rebenstock
Publikováno v:
Chemistry – A European Journal. 4:935-941
A “state of the art” route to enantiomerically pure synthetic α-amino acids on a multigram scale from commonly available starting materials (below) is described; it relies on the combination of palladium-catalyzed amidocarbonylation and enantios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f32b2c0fc7a21947725f000fb89bb97
https://doi.org/10.1002/(sici)1521-3765(19980515)4:5<935::aid-chem935>3.0.co
https://doi.org/10.1002/(sici)1521-3765(19980515)4:5<935::aid-chem935>3.0.co