Výsledky vyhledávání - "Wolfgang H.G. Laux"

Triarylmethyl Substituted 4,5-Dicyanoimidazoles as Activators for Rp-Diastereoselective Synthesis of TpN Dinucleoside Methylphosphonates

Autor: Peter Schell, Wolfgang H.G. Laux, Joachim W. Engels

Publikováno v: Nucleosides and Nucleotides. 18:1169-1174

2-Triarylmethyl-4,5-dicyanoimidazoles 1–3 were synthesized and tested as activators in the methylphosphonamidite approach. TpN dinucleoside methylphosphonates generated showed diastereoselectivity of up to 8 / 1 (Rp / Sp). The influence of the diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da2e5371c502223d125c0c71067cbb53
https://doi.org/10.1080/07328319908044654

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Enantioselective synthesis of diisopropyl α-, β-, and γ-hydroxyarylalkylphosphonates from ketophosphonates: A study on the effect of the phosphonyl group

Autor: Wolfgang H.G. Laux, Chris Meier

Publikováno v: Tetrahedron. 52:589-598

A comparative study of different reduction conditions to an enantioselective synthesis of diisopropyl α-, β- and γ-hydroxyphosphonates 4–6 by 1.3.2-oxazaborolidine catalysis using catecholborane 7 or BH 3 ·Me 2 S 8 is described. The comparison

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::033a860aeeebba91b39f54020af3b8b9
https://doi.org/10.1016/0040-4020(95)00855-1

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Asymmetric synthesis of chiral, Nonracemic dialkyl-α-hydroxyalkylphosphonates via a (−)-Chlorodiiso-pinocampheylborane (Ipc2B-Cl) reduction

Autor: Chris Meier, Wolfgang H.G. Laux

Publikováno v: Tetrahedron: Asymmetry. 7:89-94

The enantioselective synthesis of dialkyl α-hydroxybenzylphosphonates 2 using a (−)-chlorodiisopinocampheylborane (Ipc 2 B-Cl) 3 catalyed reduction starting with α-keto-phosphonates 1 is described. The reaction gave the target compounds 2 in good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::388f144163e46f02d144716a71c9dc1b
https://doi.org/10.1016/0957-4166(95)00424-6

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Asymmetric synthesis of chiral, nonracemic dialkyl α-hydroxyarylmethyl-and α-, β- and γ-hydroxyalkylphosphonates from keto phosphonates

Autor: Jan W. Bats, Wolfgang H.G. Laux, Chris Meier

Publikováno v: Liebigs Annalen. 1995:1963-1979

The enantioselective synthesis of α-hydroxyarylmethylphosphonates 2a-p by the oxazaborolidine-catalyzed reduction of α-keto phosphonates 1a-p using different boranes 4a–c was studied in detail. Moderate to good enantioselectivities are found (up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c02e928a8590ff5589d00f9b256bbd67
https://doi.org/10.1002/jlac.1995199511276

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Homo Dinucleoside-α-hydroxyphosphonate Diesters as Prodrugs of the Antiviral Nucleoside Analogues 2',3'-Dideoxythymidine and 3'-Azido-2',3'-dideoxythymidine

Autor: Chris Meier, Wolfgang H.G. Laux, Jan Balzarini, Erik De Clercq, Lothar W. Habel

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 14:759-762

The synthesis of a new prodrug system for antiviral nucleosides AZT (1) and ddT (2) based on α-hydroxybenzylphosphonates 3 is described. 3 hydrolyze via different mechanisms yielding the H-phosphonate monoesters 4 or nucleoside monophosphates 5, res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0a70f4ac63df4fa1c8ee88dd5e33362
https://doi.org/10.1080/15257779508012466

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Asymmetric synthesis of chiral, nonracemic dialkyl-α-, β-, and γ-hydroxyalkylphosphonates via a catalyzed enantioselective catecholborane reduction

Autor: Wolfgang H.G. Laux, Chris Meier

Publikováno v: Tetrahedron: Asymmetry. 6:1089-1092

A highly enantioselective synthesis of dialkyl α-hydroxyphosphonates achieved by a oxazaborolidine catalyzed reduction with catecholborane starting with α-ketophosphonates is described. Both α-aryl- and α-alkylketophosphonates were reduced using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2b4377c6fa7eaca1222cbca21cdb5c0
https://doi.org/10.1016/0957-4166(95)00132-9

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