Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Wolfgang G. Junger"'
Autor:
Carola Ledderose, Eleftheria-Angeliki Valsami, Mark Elevado, Qing Liu, Brennan Giva, Julian Curatolo, Joshua Delfin, Reem Abutabikh, Wolfgang G. Junger
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Background The function of polymorphonuclear neutrophils (PMNs) decreases with age, which results in infectious and inflammatory complications in older individuals. The underlying causes are not fully understood. ATP release and autocrine st
Externí odkaz:
https://doaj.org/article/a42dfe66f023464695a745dd11c12ea6
Autor:
Aiping Bai, Alan Moss, Sonja Rothweiler, Maria Serena Longhi, Yan Wu, Wolfgang G. Junger, Simon C. Robson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ef28daa6ed6f4fb999a3ed66d699f3af
Autor:
Carola Ledderose, Wolfgang G. Junger
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Intracellular ATP is the universal energy carrier that fuels many cellular processes. However, immune cells can also release a portion of their ATP into the extracellular space. There, ATP activates purinergic receptors that mediate autocrine and par
Externí odkaz:
https://doaj.org/article/e388b749fdc14df1a70b7a88b85ae4c0
Autor:
Stephan Ledderose, Severin Rodler, Lennert Eismann, Georg Ledderose, Martina Rudelius, Wolfgang G. Junger, Carola Ledderose
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2321
Bladder cancer is amongst the most common causes of cancer death worldwide. Muscle-invasive bladder cancer (MIBC) bears a particularly poor prognosis. Overexpression of purinergic P2X receptors (P2XRs) has been associated with worse outcome in severa
Autor:
Carola Ledderose, Eleftheria-Angeliki Valsami, Margaret Newhams, Mark-Josef Elevado, Tanya Novak, Adrienne G. Randolph, Wolfgang G. Junger
Publikováno v:
Purinergic Signalling.
Neutrophils (PMNs) require extracellular ATP and adenosine (ADO) to fight bacterial infections, which often have life-threatening consequences in pediatric patients. We wondered whether the ATP and ADO levels in the plasma of children change with age
Autor:
Carola Ledderose, Naoyuki Hashiguchi, Eleftheria-Angeliki Valsami, Christian Rusu, Wolfgang G. Junger
Publikováno v:
Journal of immunological methods. 512
Polymorphonuclear neutrophils (PMNs) protect the host from invading microorganisms. However, excessively activated PMNs can also cause damage to host tissues under inflammatory conditions. Here we developed simple assays to determine the activation s
Publikováno v:
Purinergic Signal
ATP released into the bloodstream regulates immune responses and other physiological functions. Excessive accumulation of extracellular ATP interferes with these functions, and elevated plasma ATP levels could indicate infections and other pathologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0aea036cf585ddd467d961d5f539229
https://europepmc.org/articles/PMC9123122/
https://europepmc.org/articles/PMC9123122/
Autor:
Prakash K Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G Junger, Simon C Robson, E John Wherry, Galit Alter, Philip J R Goulder, Paul Klenerman, Arlene H Sharpe, Georg M Lauer, W Nicholas Haining
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005177 (2015)
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. H
Externí odkaz:
https://doaj.org/article/a33577d938d04eef98014e4ae8a823b4
Autor:
Carola Ledderose, Koichiro Sueyoshi, Yutaka Kondo, Mahtab Fakhari, Christian J. Slubowski, Yi Bao, Xiaoou Li, Soheyl Bahrami, Wolfgang G. Junger, Jingping Zhang
Publikováno v:
Shock
Ischemia and reperfusion injury following severe trauma or cardiac arrest are major causes of organ damage in intensive care patients. The brain is particularly vulnerable because hypoxia rapidly damages neurons due to their heavy reliance on oxidati
Publikováno v:
Purinergic Signalling. 15:127-137
Previous studies have shown that T cell receptor (TCR) and CD28 coreceptor stimulation involves rapid ATP release, autocrine purinergic feedback via P2X receptors, and mitochondrial ATP synthesis that promote T cell activation. Here, we show that ADP