Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Wolfgang G. Eberlein"'
Autor:
Victor Fuchs, Janice M. Rose, Kollol Pal, Mark L. Behnke, Wolfhard W. Engel, Usha R. Patel, Scot J. Campbell, Suresh R. Kapadia, Julian Adams, Jerry W. Skiles, Joe C. Wu, Gunther Schmidt, Grozinger Karl G, Alan S. Rosenthal, Tracy D. Saboe, Wolfgang G. Eberlein, Jana Vitous, Janice M. Klunder, John R. Proudfoot, Ernest Cullen, Mark T. Skoog, Mcneil Daniel W, Scott C. Mauldin, Grace C. Chow, Karl D. Hargrave
Publikováno v:
Journal of Medicinal Chemistry. 34:2231-2241
Novel pyrido[2,3-b][1,4]benzodiazepinones (I), pyrido[2,3-b][1,5]benzodiazepinones (II), and dipyrido[3,2-b:2',3'-e][1,4]diazepinones (III) were found to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in vitro at concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680f1db75eddd4d131f02bf1a70896f9
https://doi.org/10.1021/jm00111a045
https://doi.org/10.1021/jm00111a045
Publikováno v:
Journal of Medicinal Chemistry. 31:1169-1174
In order to gain some insight into those structural features that control M1 selectivity, a selected set of pirenzepine analogues has been studied in which both the tricyclic ring system and the basic side chain have been varied. Binding studies were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776ba76ee088da302741e188395b27c5
https://doi.org/10.1021/jm00401a016
https://doi.org/10.1021/jm00401a016
Autor:
Helmut Pelzer, Wolfhard W. Engel, Guenter Trummlitz, Mayer Norbert, Wolfgang G. Eberlein, Guenther Schmidt
Publikováno v:
Journal of Medicinal Chemistry. 30:1378-1382
The M1-selective antiulcer drug pirenzepine (1) is a tricyclic compound with close resemblance to tricyclic psychotropic agents such as imipramine (2). Despite this fact, pirenzepine is devoid of any psychotropic effects, exhibiting measurable antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64791d8d218f68208e12f79db7eefec0
https://doi.org/10.1021/jm00391a019
https://doi.org/10.1021/jm00391a019
Publikováno v:
Journal of medicinal chemistry. 32(8)
On the basis of the cardioselective muscarinic receptor antagonist AF-DX 116 (2), a series of 11-substituted pyridobenzodiazepinones (9-35) was prepared and screened for their binding affinity to muscarinic receptors located in cardiac (M2) and gland
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefe768f0bb5ba54481b4d01c2d100a1
https://pubmed.ncbi.nlm.nih.gov/2754696
https://pubmed.ncbi.nlm.nih.gov/2754696