Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Wolfgang Frieß"'
Autor:
Cornelia Hiemenz, Nadine Baumeister, Constanze Helbig, Andrea Hawe, Sabrina Babutzka, Stylianos Michalakis, Wolfgang Friess, Tim Menzen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101162- (2023)
Recombinant adeno-associated viruses (rAAVs) are attractive therapeutic viral vectors for gene delivery. To ensure the efficacy and safety of rAAV-based therapies, comprehensive characterization of the adeno-associated virus (AAV) capsids is essentia
Externí odkaz:
https://doaj.org/article/021bc972a55c4085adb2165aff1ec1da
Autor:
Brecht Vanbillemont, Anna-Lena Greiner, Vanessa Ehrl, Tim Menzen, Wolfgang Friess, Andrea Hawe
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100180- (2023)
Freeze-drying is a time and cost-intensive process. The primary drying phase is the main target in a process optimization exercise. Biopharmaceuticals require an amorphous matrix for stabilization, which may collapse during primary drying if the crit
Externí odkaz:
https://doaj.org/article/e764e9c5ffc64cc7acc9036b48afe182
Autor:
Oliver Bluemel, Moritz Anuschek, Jakob W. Buecheler, Georg Hoelzl, Karoline Bechtold-Peters, Wolfgang Friess
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100108- (2022)
Cryoconcentration upon large-scale freezing of monoclonal antibody (mAb) solutions leads to regions of different ratios of low molecular weight excipients, like buffer species or sugars, to protein. This study focused on the impact of the buffer spec
Externí odkaz:
https://doaj.org/article/fd256466ddc24d6b90e2553153595503
Autor:
Oliver Bluemel, Jakob W. Buecheler, Astrid Hauptmann, Georg Hoelzl, Karoline Bechtold-Peters, Wolfgang Friess
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100109- (2022)
We examined the impact of monoclonal antibody (mAb) and buffer concentration, mimicking the cryoconcentration found upon freezing in a 2 L bottle, on mAb stability during frozen storage. Upon cryoconcentration, larger protein molecules and small exci
Externí odkaz:
https://doaj.org/article/102d6db52a574b688c2bf0c48f47b113
Autor:
Alina Kulakova, Sowmya Indrakumar, Pernille Sønderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang Frieß, Günther H.J. Peters, Pernille Harris
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100017- (2020)
Transferrin is an attractive candidate for drug delivery due to its ability to cross the blood brain barrier. However, in order to be able to use it for therapeutic purposes, it is important to investigate how its stability depends on different formu
Externí odkaz:
https://doaj.org/article/a92acadb0a5249629cba80c8d938c834
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 61 (2020)
Small batch sizes are a consequence of more personalized medicine and reflect a trend in the biopharmaceutical industry. Freeze drying of vials nested in a rack system is a tool used in new flexible pilot scale processing lines. Understanding of heat
Externí odkaz:
https://doaj.org/article/b683f68728ac45cdae2ee18852d1ef17
Autor:
Jacqueline Horn, Wolfgang Friess
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
The collapse temperature (Tc) and the glass transition temperature of freeze-concentrated solutions (Tg') as well as the crystallization behavior of excipients are important physicochemical characteristics which guide the cycle development in freeze-
Externí odkaz:
https://doaj.org/article/6216e7507982412db18f5b1585532440
Publikováno v:
Pharmaceutics, Vol 11, Iss 11, p 616 (2019)
Short freeze-drying cycles for biopharmaceuticals are desirable. Formulations containing an amorphous disaccharide, such as sucrose, are prone to collapse upon aggressive primary drying at higher shelf temperature. We used 2-hydroxypropyl-betacyclode
Externí odkaz:
https://doaj.org/article/e3a23c7a3c5a4404857650abd3990963
Publikováno v:
Journal of Pharmaceutical Sciences. 112:665-672
Tangential flow filtration (TFF) is a central step in manufacturing of biopharmaceutics. Membrane clogging leads to decreased permeate flux, longer process time and potentially complete failure of the process. The effect of peristaltic pumping with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438a7f45cdd91828787b28fb944cd7df
https://doi.org/10.1016/j.xphs.2022.10.005
https://doi.org/10.1016/j.xphs.2022.10.005
Autor:
Anian, Thaller, Lukas, Schmauder, Wolfgang, Frieß, Gerhard, Winter, Tim, Menzen, Andrea, Hawe, Klaus, Richter
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 182:152-156
During the SARS-CoV2 pandemic mRNA vaccines in the form of lipid nanoparticles (LNPs) containing the mRNA, have set the stage for a new area of vaccines. Analytical methods to quantify changes in size and structure of LNPs are crucial, as changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c94b54c4fc6d4661c06ffbd68e4670
https://doi.org/10.1016/j.ejpb.2022.11.014
https://doi.org/10.1016/j.ejpb.2022.11.014