Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wolfgang Esser-Skala"'
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Deep neural networks display impressive performance but suffer from limited interpretability. Biology-inspired deep learning, where the architecture of the computational graph is based on biological knowledge, enables unique interpretability
Externí odkaz:
https://doaj.org/article/3e30a8e11c34441ea6ca1b45bc7c5160
Autor:
Irfete S. Fetahu, Wolfgang Esser-Skala, Rohit Dnyansagar, Samuel Sindelar, Fikret Rifatbegovic, Andrea Bileck, Lukas Skos, Eva Bozsaky, Daria Lazic, Lisa Shaw, Marcus Tötzl, Dora Tarlungeanu, Marie Bernkopf, Magdalena Rados, Wolfgang Weninger, Eleni M. Tomazou, Christoph Bock, Christopher Gerner, Ruth Ladenstein, Matthias Farlik, Nikolaus Fortelny, Sabine Taschner-Mandl
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here
Externí odkaz:
https://doaj.org/article/117133ab2f214dc88c7d58fa27ea3acd
Autor:
Fiammetta Di Marco, Thomas Berger, Wolfgang Esser-Skala, Erdmann Rapp, Christof Regl, Christian G. Huber
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 9072 (2021)
Different manufacturing processes and storage conditions of biotherapeutics can lead to a significant variability in drug products arising from chemical and enzymatic post-translational modifications (PTMs), resulting in the co-existence of a plethor
Externí odkaz:
https://doaj.org/article/454f1ba64dad4839bd61cf9a8edcc2ee
Autor:
Fiammetta Di Marco, Constantin Blöchl, Wolfgang Esser-Skala, Veronika Schäpertöns, Tao Zhang, Manfred Wuhrer, Koen Sandra, Therese Wohlschlager, Christian G. Huber
Characterisation of highly glycosylated biopharmaceuticals by mass spectrometry is challenging because of the huge chemical space of co-existent glycoforms, i.e. heterogenous glycoprotein variants. Here, we report the use of an array of HPLC-MS-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::590eba4b1422a9a3a52501df84acd287
https://doi.org/10.26434/chemrxiv-2022-87twx
https://doi.org/10.26434/chemrxiv-2022-87twx
Publikováno v:
Angewandte Chemie. 132:16359-16367
Publikováno v:
Proteolytic Signaling in Health and Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::038f646b9665b3abc2f72016794ce836
https://doi.org/10.1016/b978-0-323-85696-6.00001-9
https://doi.org/10.1016/b978-0-323-85696-6.00001-9
Autor:
Luiz G.N. de Almeida, Ulrich auf dem Keller, Thamali Ayagama, Uilla Barcick, Samuel J. Bose, Louise Bundgaard, Rebecca A.B. Burton, Daniela Cajado-Carvalho, Maurício Frota Camacho, Niels Olsen Saraiva Câmara, Camila Rolemberg Santana Travaglini Berti de Correia, Patrícia Maria Siqueira dos Passos, Antoine Dufour, Wolfgang Esser-Skala, Jessica de Alcantara Ferreira, Nikolaus Fortelny, Vanessa Morais Freitas, Daniela C. Granato, Hinrich P. Hansen, Tâmisa Seeko Bandeira Honda, Pitter F. Huesgen, Ruy Gastaldoni Jaeger, Konstantinos Kalogeropoulos, Maithreyan Kuppusamy, Andrei Leitão, Adriana F. Paes Leme, João Agostinho Machado-Neto, Isabela Fernanda Morales Martins, Milene Cristina Menezes, Leandro X. Neves, Caio Almeida Batista de Oliveira, Barbara Nunes Padovani, Murilo Salardani, Adriane Sousa de Siqueira, Valentine Spagnol, Felipe Roberti Teixeira, Dilza Trevisan-Silva, Luciana D. Trino, André Zelanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88de102292cfe3bc0830f0145afb68b9
https://doi.org/10.1016/b978-0-323-85696-6.09991-1
https://doi.org/10.1016/b978-0-323-85696-6.09991-1
Autor:
Wolfgang Esser-Skala, Erdmann Rapp, Thomas Berger, Christian G. Huber, Christof Regl, Fiammetta Di Marco
The increasing importance of biosimilars in the biopharmaceutical market leads to high demands for enhanced protein characterization methods. Different manufacturing processes can lead to a significant variability of biotherapeutics arising from chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a73ff2f4c979a1fbe56791198804ed2
https://doi.org/10.26434/chemrxiv-2021-87m9w
https://doi.org/10.26434/chemrxiv-2021-87m9w
Publikováno v:
Analytica Chimica Acta. 1207:339813
(1) Background: The N-glycosylation profile as well as the subunit assembly of monoclonal antibodies (mAbs) are strongly dependent on manufacturing conditions and thus need to be monitored during the bioprocess. Commonly, mAbs are characterized downs
Autor:
Maximilian Lebede, Fiammetta di Marco, Wolfgang Esser-Skala, René Hennig, Therese Wohlschlager, Christian G. Huber
Exploration of a highly glycosylated non-covalent protein comples by mass spectreometry is a challenging task due to isobarisicy of the majority of glycoforms. Integration of data from multiple structural levels (released glycan-glycopeptide-protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef55a5c18effd737cfad094f8ba0772
https://doi.org/10.26434/chemrxiv.14153249.v1
https://doi.org/10.26434/chemrxiv.14153249.v1