Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Wolfgang E. Thasler"'
Publikováno v:
Livers, Vol 3, Iss 2, Pp 282-292 (2023)
The activation of hepatic stellate cells (HSCs) is the key event of hepatic fibrosis. Furthermore, activated HSCs also play an important role in the progression of hepatocellular cancer (HCC). Bone morphogenetic protein 14 (BMP14) is a member of the
Externí odkaz:
https://doaj.org/article/bcd2d93ad61c41f2b453772d532074e7
Autor:
Knud Esser, Xiaoming Cheng, Jochen M. Wettengel, Julie Lucifora, Lea Hansen-Palmus, Katharina Austen, Armando A. Roca Suarez, Sarah Heintz, Barbara Testoni, Firat Nebioglu, Minh Tu Pham, Shangqing Yang, Alma Zernecke, Dirk Wohlleber, Marc Ringelhan, Mathias Broxtermann, Daniel Hartmann, Norbert Hüser, Julia Mergner, Andreas Pichlmair, Wolfgang E. Thasler, Mathias Heikenwalder, Georg Gasteiger, Andreas Blutke, Axel Walch, Percy A. Knolle, Ralf Bartenschlager, Ulrike Protzer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 2, Pp 201-221 (2023)
Background & Aims: A single hepatitis B virus (HBV) particle is sufficient to establish chronic infection of the liver after intravenous injection, suggesting that the virus targets hepatocytes via a highly efficient transport pathway. We therefore i
Externí odkaz:
https://doaj.org/article/9fd675743fc64b5f93ebf586a31ab2ba
Autor:
Vanessa Kersten, Tatjana Seitz, Judith Sommer, Wolfgang E. Thasler, Anja Bosserhoff, Claus Hellerbrand
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11059 (2023)
Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrosis and, thus, build the “soil” for hepatocarcinogenesis. Furthermore, HSCs are known to promote the progression of hepatocellular carcinoma (HCC), but the molecular mechanis
Externí odkaz:
https://doaj.org/article/72130e2e31e94e5ab7193c767ec0fada
Autor:
Anne Gaza, Valerie Fritz, Lara Malek, Laura Wormser, Nora Treiber, Johannes Danner, Andreas E. Kremer, Wolfgang E. Thasler, Jürgen Siebler, Gunter Meister, Markus F. Neurath, Claus Hellerbrand, Anja K. Bosserhoff, Peter Dietrich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 5, Pp 502-514 (2021)
The poor prognosis of advanced hepatocellular carcinoma (HCC) is driven by diverse features including dysregulated microRNAs inducing drug resistance and stemness. Lin-28 homolog A (LIN28A) and its partner zinc finger CCHC-type containing 11 (ZCCHC11
Externí odkaz:
https://doaj.org/article/ce90753935094bce83d17dd21852b8b8
Autor:
Tatjana Seitz, Nora John, Judith Sommer, Peter Dietrich, Wolfgang E. Thasler, Arndt Hartmann, Katja Evert, Sven A. Lang, Anja Bosserhoff, Claus Hellerbrand
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11524 (2022)
Hepatic metastasis is the critical factor determining tumor-associated mortality in different types of cancer. This is particularly true for uveal melanoma (UM), which almost exclusively metastasizes to the liver. Hepatic stellate cells (HSCs) are th
Externí odkaz:
https://doaj.org/article/9daf2278552f44aa8afa2628bc38bd25
Autor:
Valerie Fritz, Lara Malek, Anne Gaza, Laura Wormser, Majken Appel, Andreas E. Kremer, Wolfgang E. Thasler, Jürgen Siebler, Markus F. Neurath, Claus Hellerbrand, Anja K. Bosserhoff, Peter Dietrich
Publikováno v:
Cancers, Vol 13, Iss 5, p 1183 (2021)
Chemoresistance is a major hallmark driving the progression and poor prognosis of hepatocellular carcinoma (HCC). Limited chemoresponse of HCC was demonstrated to be mediated by mitogen-activated protein kinase 14 (MAPK14) and activating transcriptio
Externí odkaz:
https://doaj.org/article/276b33f1cf8b41938778cb6ee5bf5416
Autor:
Tobias S. Schiergens, Moritz Drefs, Maximilian Dörsch, Florian Kühn, Markus Albertsmeier, Hanno Niess, Markus B. Schoenberg, Matthias Assenmacher, Helmut Küchenhoff, Wolfgang E. Thasler, Markus O. Guba, Martin K. Angele, Markus Rentsch, Jens Werner, Joachim Andrassy
Publikováno v:
Cancers, Vol 13, Iss 1, p 72 (2020)
Pedicle clamping (PC) during liver resection for colorectal metastases (CRLM) is used to reduce blood loss and allogeneic blood transfusion (ABT). The effect on long-term oncologic outcomes is still under debate. A retrospective analysis of the impac
Externí odkaz:
https://doaj.org/article/7410893cca4d40c3a7ca16c984f9ac4f
Autor:
Judith Sommer, Christoph Dorn, Erwin Gäbele, Frauke Bataille, Kim Freese, Tatjana Seitz, Wolfgang E. Thasler, Reinhard Büttner, Ralf Weiskirchen, Anja Bosserhoff, Claus Hellerbrand
Publikováno v:
Cells, Vol 9, Iss 1, p 248 (2020)
Cholestasis occurs in different clinical circumstances and leads to severe hepatic disorders. The four-and-a-half LIM-domain protein 2 (FHL2) is a scaffolding protein that modulates multiple signal transduction pathways in a tissue- and cell context-
Externí odkaz:
https://doaj.org/article/62a39e3eba324b7d8d34896457195cbc
Autor:
Thomas Klag, Maria Thomas, Dirk Ehmann, Lioba Courth, Daniela Mailänder-Sanchez, Thomas S. Weiss, Rania Dayoub, Kerstin Abshagen, Brigitte Vollmar, Wolfgang E. Thasler, Eduard F. Stange, Christoph P. Berg, Nisar P. Malek, Ulrich M. Zanger, Jan Wehkamp
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background & aimsKnowledge about innate antimicrobial defense of the liver is limited. We investigated hepatic expression and regulation of antimicrobial peptides with focus on the human beta defensin-1 (hBD-1).MethodsRadial diffusion assay was used
Externí odkaz:
https://doaj.org/article/758afb4f1b044c01a3cc3e8ddec592b7
Autor:
Kim Freese, Tatjana Seitz, Peter Dietrich, Serene M.L. Lee, Wolfgang E. Thasler, Anja Bosserhoff, Claus Hellerbrand
Publikováno v:
Cancers, Vol 11, Iss 10, p 1587 (2019)
Hepatocellular carcinoma (HCC) is a leading cause for deaths worldwide. Histone deacetylase (HDAC) inhibition (HDACi) is emerging as a promising therapeutic strategy. However, most pharmacological HDACi unselectively block different HDAC classes and
Externí odkaz:
https://doaj.org/article/31bc0b4587964213b514a022a1ccf8c7