Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Wolfgang E. F. Klinkert"'
Autor:
Martin Vingron, Christian Schläger, Alexander Flügel, Hans Lehrach, Cassandra Flügel-Koch, Claudio Lottaz, Wilfried Nietfeld, Vijay Kumar Ulaganathan, Dmitri Lodygin, Volker Brinkmann, Wolfgang E. F. Klinkert, Klaus Heckelsmiller, Rainer Spang, Joachim W. Ellwart, Hartmut Wekerle, Francesca Odoardi, Mikhail Nosov, Christopher Sie, Kristina Streyl
Publikováno v:
Nature
The blood–brain barrier (BBB) and the environment of the central nervous system (CNS) guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple sclerosis, myelin-reactive T-cell blasts are thought to transgress the B
Autor:
Klaus Dornmair, Barry V. L. Potter, Detlev Schild, Esther Breunig, Dimtri Lodygin, Chiara Cordiglieri, Alexander Flügel, Naoto Kawakami, Wolfgang E. F. Klinkert, Vijay Kumar Ulaganathan, Werner Dammermann, Merle Nebel, Andreas H. Guse, Fred Lühder, Francesca Odoardi, Bo Zhang
Publikováno v:
Brain
Cordiglieri, C, Odoardi, F, Zhang, B, Nebel, M, Kawakami, N, Klinkert, W E F, Lodygin, D, Luhder, F, Breunig, E, Schild, D, Ulaganathan, V K, Dornmair, K, Dammermann, W, Potter, B V L, Guse, A H & Flugel, A 2010, ' Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system ', Brain, vol. 133, no. 7, pp. 1930-1943 . https://doi.org/10.1093/brain/awq135
Cordiglieri, C, Odoardi, F, Zhang, B, Nebel, M, Kawakami, N, Klinkert, W E F, Lodygin, D, Luhder, F, Breunig, E, Schild, D, Ulaganathan, V K, Dornmair, K, Dammermann, W, Potter, B V L, Guse, A H & Flugel, A 2010, ' Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system ', Brain, vol. 133, no. 7, pp. 1930-1943 . https://doi.org/10.1093/brain/awq135
Nicotinic acid adenine dinucleotide phosphate represents a newly identified second messenger in T cells involved in antigen receptor-mediated calcium signalling. Its function in vivo is, however, unknown due to the lack of biocompatible inhibitors. U
Autor:
Roland Goldbrunner, Wolfgang E. F. Klinkert, Jochen Herms, Martin Fuhrmann, Yvonne Kienast, Frank Winkler, Louisa von Baumgarten
Publikováno v:
Nature Medicine. 16:116-122
Brain metastasis frequently occurs in individuals with cancer and is often fatal. We used multiphoton laser scanning microscopy to image the single steps of metastasis formation in real time. Thus, it was possible to track the fate of individual meta
Autor:
Francesca Odoardi, Ingo Bartholomäus, Naoto Kawakami, Cassandra Flügel-Koch, Alexander Flügel, Wolfgang E. F. Klinkert, Thomas B. Issekutz, Hartmut Wekerle, Djordje Miljković, Christian Schläger, Joachim W. Ellwart
Publikováno v:
Nature. 462:94-98
The tissues of the central nervous system are effectively shielded from the blood circulation by specialized vessels that are impermeable not only to cells, but also to most macromolecules circulating in the blood. Despite this seemingly absolute sec
Autor:
Wolfgang E. F. Klinkert, Heinrich Leonhardt, Karin Fellinger, Ian Marc Bonapace, Ulrich Rothbauer, Fabio Spada, Daniela Meilinger, Sebastian Bultmann
Publikováno v:
EMBO Reports
Recent studies have indicated that nuclear protein of 95 kDa (Np95) is essential for maintaining genomic methylation by recruiting DNA methyltransferase (Dnmt) 1 to hemi-methylated sites. Here, we show that Np95 interacts more strongly with regulator
Autor:
Naoto Kawakami, Alexander Flügel, Wolfgang E. F. Klinkert, Francesca Odoardi, Hartmut Wekerle
Publikováno v:
Proceedings of the National Academy of Sciences. 104:18625-18630
We explored the effect of i.v. soluble antigen on autoaggressive, myelin basic protein-specific effector T cells within their target organ during acute experimental autoimmune encephalomyelitis (EAE). Intravital two-photon imaging revealed that i.v.
Autor:
Francesca Odoardi, Jan Bauer, Wolfgang E. F. Klinkert, Mikhail Nosov, Joachim W. Ellwart, Hartmut Wekerle, Alexander Flügel, Zhaoxia Li, Naoto Kawakami, Chiara Cordiglieri, Hans Lassmann, Kristina Streyl
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 104, 920-925 (2007)
i.v. infusion of native autoantigen or its altered peptide variants is an important therapeutic option for the treatment of autoimmune diseases, because it selectively targets the disease-inducing T cells. To learn more about the mechanisms and kinet
Autor:
Katherina Siewert, Hartmut Wekerle, Latika Bhonsle-Deeng, Klaus Dornmair, Eduardo Beltrán, Wakiro Sato, Thomas Misgeld, David-Axel Laplaud, Geraldine Rühl, Stephan Schmidt, Holger Babbe, Markus Moser, Reinhard Hohlfeld, Peter Engerer, Judy K.M. Ng, Wolfgang E. F. Klinkert, Kathrin Held
Publikováno v:
Neurology Neuroimmunology & Neuroinflammation
Neurology Neuroimmunology & Neuroinflammation, 2015, 2 (4), pp.e107. ⟨10.1212/NXI.0000000000000107⟩
Neurology Neuroimmunology & Neuroinflammation, American Academy of neurology, 2015, 2 (4), pp.e107. ⟨10.1212/NXI.0000000000000107⟩
Neurology® Neuroimmunology & Neuroinflammation
Neurology 2(4), e107 (2015). doi:10.1212/NXI.0000000000000107
Neurology Neuroimmunology & Neuroinflammation, 2015, 2 (4), pp.e107. ⟨10.1212/NXI.0000000000000107⟩
Neurology Neuroimmunology & Neuroinflammation, American Academy of neurology, 2015, 2 (4), pp.e107. ⟨10.1212/NXI.0000000000000107⟩
Neurology® Neuroimmunology & Neuroinflammation
Neurology 2(4), e107 (2015). doi:10.1212/NXI.0000000000000107
OBJECTIVES: To characterize phenotypes of T cells that accumulated in multiple sclerosis (MS) lesions, to compare the lesional T-cell receptor (TCR) repertoire of T-cell subsets to peripheral blood, and to identify paired alpha and beta chains from s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d4eecb9c03a95ba1f8f61c352e25e6
https://hdl.handle.net/11858/00-001M-0000-002A-1777-B11858/00-001M-0000-002A-1779-7
https://hdl.handle.net/11858/00-001M-0000-002A-1777-B11858/00-001M-0000-002A-1779-7
Autor:
Hauke Schneider, Reinhard Hohlfeld, Tania Kümpfel, Wolfgang E. F. Klinkert, Oliver Neuhaus, Tjalf Ziemssen
Publikováno v:
Journal of the Neurological Sciences. 233:109-112
Treatment with glatiramer acetate (GA) is thought to induce an in vivo change of the cytokine secretion pattern and the effector function of GA-reactive T helper (TH) cells (TH1-TH2-shift). Current theories propose that GA-reactive TH2 cells can pene
Autor:
Paolo Malatesta, Michael A. Hack, Magdalena Götz, Frank Kirchhoff, Eva Hartfuss, Wolfgang E. F. Klinkert, Helmut Kettenmann
Publikováno v:
Neuron. 37:751-764
The precursor function of the ubiquitous glial cell type in the developing central nervous system (CNS), the radial glia, is largely unknown. Using Cre/loxP in vivo fate mapping studies, we found that radial glia generate virtually all cortical proje