Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Wolfgang E, Merz"'
1
Inhibition of gonadotropin-stimulated steroidogenesis by the erk cascade
Autor: Jerome F. Strauss, Rony Seger, Revital Rosenberg, Wolfgang E. Merz, Tamar Hanoch, Ada Dantes, Abraham Amsterdam
LH and FSH are two important hormones in the regulation of granulosa cells. Their effects are mediated mainly by cAMP/PKA signaling, bit the activity of the extracellular signal-regulated kinase (ERK) signaling cascade is elevated as well. We studied
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408f7ed132af089866b0ad85e0aa7f9a
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2
The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis
Autor: Revital Rosenberg, Wolfgang E. Merz, Rony Seger, Ada Dantes, Abraham Amsterdam, Tamar Hanoch, Jerome F. Strauss
The response of granulosa cells to luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is mediated mainly by cAMP/protein kinase A (PKA) signaling. Notably, the activity of the extracellular signal-regulated kinase (ERK) signaling cascade
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c243feeb4c7be3c322680938e7ca6c7
https://europepmc.org/articles/PMC5448111/
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4
Nonassembled Human Chorionic Gonadotropin Subunits and αα-Homodimers Use Fast-Track Processing in the Secretory Pathway in Contrast to αβ-Heterodimers
Autor: Wolfgang E. Merz, Vinod Singh, Peter Berger, Jordi Roig, Jean-Michel Krause
Publikováno v: Endocrinology. 148:5831-5841
In multimeric glycoproteins, like glycoprotein hormones, mutual subunit interactions are required for correct folding, assembly, and transport in the secretory pathway. However, character and time course of these interactions need further elucidation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b47e23354bde98b46f01ab7adc05d7
https://doi.org/10.1210/en.2007-0789
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5
Rapid Maturation of Glycoprotein Hormone Free α-Subunit (GPHα) and GPHαα Homodimers
Autor: Jordi Roig, Peter Berger, Vinod Singh, Wolfgang E. Merz, Jean-Michel Krause
Publikováno v: Molecular Endocrinology. 21:2551-2564
The dynamics of glycoprotein hormone α-subunit (GPHα) maturation and GPHαα homodimer formation were studied in presence (JEG-3 choriocarcinoma cells) and absence (HeLa cells) of hCGβ. In both cases, the major initially occurring GPHα variant in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8343c5f4ea54b01af157a016b005a79f
https://doi.org/10.1210/me.2007-0051
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6
Human chorionic gonadotropin (hCG) in the male reproductive tract
Autor: Peter Berger, Matthias S. Gruschwitz, Stephan Dirnhofer, Natalie Sampson, Eugen Plas, R. Gerth, G. Spoettl, Stephan Madersbacher, Wolfgang E. Merz
Publikováno v: Molecular and Cellular Endocrinology. :190-196
Normal hypothalamic-pituitary testicular and prostatic functions are essential for maintenance of male fertility, whereby glycoprotein hormones (GPH) as well as androgens are major endocrine and local regulators. We have investigated whether the GPH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e0552c0f2ae8efa89cea589844efa9
https://doi.org/10.1016/j.mce.2006.01.021
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8
Disulfide Bond Formation Is Not Required for Human Chorionic Gonadotropin Subunit Association
Autor: Wolfgang E. Merz, Vinod Singh
Publikováno v: Journal of Biological Chemistry. 275:11765-11770
To study the influence of disulfide bridge formation on the assembly of the subunits of human chorionic gonadotropin in JEG-3 choriocarcinoma cells, dithiothreitol (DTT) was used to create a reducing milieu in the endoplasmic reticulum (ER)in vivo. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::638c82c074694e9231bf5eb4897d3c9a
https://doi.org/10.1074/jbc.275.16.11765
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9
Regulation of N-glycosylation. Long term effect of cyclic AMP mediates enhanced synthesis of the dolichol pyrophosphate core oligosaccharide
Autor: M Konrad, Wolfgang E. Merz
Publikováno v: Journal of Biological Chemistry. 269:8659-8666
The influence of 8-bromo-cAMP on N-glycosylation in JEG-3 choriocarcinoma cells was investigated using the octanoyl-tripeptide (OTP; N-octanoyl-asparagyl-125I-tyrosyl-threonine amide) as glycosyl acceptor. In cells pretreated with 8-bromo-cAMP (2.5 n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24bce582c7f962a1b4505fb62c9270ab
https://doi.org/10.1016/s0021-9258(17)37018-7
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10
Formation of A hCG variant with truncated peptide moiety as a biosynthetic product in vitro
Autor: Wolfgang E. Merz, Laurence A. Cole, Andrew Kardana
Publikováno v: Placenta. 15:393-403
Summary In serum of tumor patients variants of human chorionic gonadotropin (hCG) or of the free β-subunit with lower molecular weights may be present as well as proteolytically nicked forms. The origin of these variants, secreted by cells or formed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bf0338a56d8af0a119b8a6cc1d0bdc
https://doi.org/10.1016/s0143-4004(05)80360-1
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