Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Wolfgang Dörner"'
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The small ubiquitin-like modifier (SUMO) is involved in various cellular processes and mediates known non-covalent protein-protein interactions by three distinct binding surfaces, whose interactions are termed class I to class III. While interactors
Externí odkaz:
https://doaj.org/article/6ef8c5a0967a4ad9b64e20c089799196
Autor:
Luca Abdel Ghani, Maria V. Yusenko, Daria Frank, Ramkumar Moorthy, John C. Widen, Wolfgang Dörner, Cyrus Khandanpour, Daniel A. Harki, Karl-Heinz Klempnauer
Publikováno v:
Cancer Letters. 530:170-180
C/EBPβ has recently emerged as a pro-leukemogenic transcription factor that cooperates with oncoprotein MYB to maintain proliferation and differentiation block of AML cells, making C/EBPβ an interesting drug target for AML. Here we have studied the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33016526348415d1937cd3d9653200e3
https://doi.org/10.1016/j.canlet.2022.01.024
https://doi.org/10.1016/j.canlet.2022.01.024
Publikováno v:
Methods in Molecular Biology ISBN: 9781071632130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece5a1434264949b91db53a70312aaea
https://doi.org/10.1007/978-1-0716-3214-7_8
https://doi.org/10.1007/978-1-0716-3214-7_8
Autor:
Bart Jan Ravoo, Dennis Reichert, Andrea Rentmeister, Wolfgang Dörner, Birte Höcker, Horst Lechner, Helena Schepers, Julian Simke
Publikováno v:
RSC Chemical Biology
The spatial and temporal control of gene expression at the post-transcriptional level is essential in eukaryotic cells and developing multicellular organisms. In recent years optochemical and optogenetic tools have enabled the manipulation and invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165272accdc383163b967f0b9e11c1f8
http://europepmc.org/articles/PMC8495969
http://europepmc.org/articles/PMC8495969
Autor:
Amke Trentmann, Debora A. Casolari, Maria V. Yusenko, Henning D. Mootz, Jan-Henrik Mikesch, Karl-Heinz Klempnauer, Mairin Lenz, Maria Francisca Arteaga, Richard J D'Andrea, Wolfgang Dörner, Stefan Klempnauer, Thomas J. Schmidt, Luca Abdel Ghani, Melanie Horn, Carsten Müller-Tidow, Thomas J. Gonda
Publikováno v:
Oncogene
Transcription factor MYB has recently emerged as a promising drug target for the treatment of acute myeloid leukemia (AML). Here, we have characterized a group of natural sesquiterpene lactones (STLs), previously shown to suppress MYB activity, for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99594c1cb67990ef093aab785965f213
http://europepmc.org/articles/PMC8298201
http://europepmc.org/articles/PMC8298201
Publikováno v:
Chemical Science
Nonribosomal peptide synthetases (NRPSs) are large, multi-modular enzyme templates for the biosynthesis of important peptide natural products. Modules are composed of a set of semi-autonomous domains that facilitate the individual reaction steps. Onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c9e36aede2d8c1548e9e0ccd232357
https://doi.org/10.1039/d0sc01969k
https://doi.org/10.1039/d0sc01969k
Publikováno v:
Chemical Communications. 55:4793-4796
We report the genetically encoded incorporation of phenylacetyl protected lysine (PacK) into proteins in Escherichia coli. This unnatural side-chain modification can be enzymatically removed using either penicillin G acylase (PGA) or, surprisingly, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d201dba2a02a2428e1d48026c87befd9
https://doi.org/10.1039/c9cc00475k
https://doi.org/10.1039/c9cc00475k
Publikováno v:
Chemical Communications. 55:1287-1290
Inteins change the structure and function of their host protein in a unique way and the Gp41-1 split intein is the fastest protein trans-splicing intein known to date. To design a photo-activatable variant, we have incorporated ortho-nitrobenzyl-tyro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbf81e39a488fc1acee0a2edb06b921
https://doi.org/10.1039/c8cc09204d
https://doi.org/10.1039/c8cc09204d
Autor:
Kim F. Taupitz, Stephanie Wulff, Henning D. Mootz, Annika Aust, Wolfgang Dörner, Kira Brüninghoff
Publikováno v:
ACS chemical biology. 15(9)
Post-translational modification with the small ubiquitin-like modifier (SUMO) affects thousands of proteins in the human proteome and is implicated in numerous cellular processes. The main outcome of SUMO conjugation is a rewiring of protein-protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167d86deeb2d2cf80bacd432a767bfcc
https://pubmed.ncbi.nlm.nih.gov/32786267
https://pubmed.ncbi.nlm.nih.gov/32786267
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
B-MYB, a highly conserved member of the MYB transcription factor family, is expressed ubiquitously in proliferating cells and plays key roles in important cell cycle-related processes, such as control of G2/M-phase transcription, cytokinesis, G1/S-ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3264b1fb7b4578c80dc41b6ce3f97db
https://doi.org/10.1038/s41598-020-65443-w
https://doi.org/10.1038/s41598-020-65443-w