Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Autor: Jan N Hansen, Fabian Kaiser, Christina Klausen, Birthe Stüven, Raymond Chong, Wolfgang Bönigk, David U Mick, Andreas Möglich, Nathalie Jurisch-Yaksi, Florian I Schmidt, Dagmar Wachten

Publikováno v: eLife, Vol 9 (2020)

Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body. Ciliary dysfunction causes sever

Externí odkaz: https://doaj.org/article/586315dafc5549b09a3829c5629e34cd

A K+-selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm

Autor: Sylvia Fechner, Luis Alvarez, Wolfgang Bönigk, Astrid Müller, Thomas K Berger, Rene Pascal, Christian Trötschel, Ansgar Poetsch, Gabriel Stölting, Kellee R Siegfried, Elisabeth Kremmer, Reinhard Seifert, U Benjamin Kaupp

Publikováno v: eLife, Vol 4 (2015)

Calcium in the flagellum controls sperm navigation. In sperm of marine invertebrates and mammals, Ca2+ signalling has been intensely studied, whereas for fish little is known. In sea urchin sperm, a cyclic nucleotide-gated K+ channel (CNGK) mediates

Externí odkaz: https://doaj.org/article/5659ad2ef0964e8487bb8bca21e42599

Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations

Autor: Hussein Hamzeh, Katharina Gutbrod, Matthias Geyer, Wolfgang Bönigk, Elena Grahn, Diana N. Raju, Heike Endepols, Heinz G. Körschen, Frank Bradke, Dominik Dittmann, Thomas K. Berger, Johannes M. F. G. Aerts, Marina A. Woeste, Peter Dörmann, Jan N. Hansen, Carina E. Marx, Roger Sandhoff, Dagmar Wachten, Sina Stern, Sophie Schonauer

Publikováno v: The Journal of Biological Chemistry
The journal of biological chemistry 294(11), 3853-3871 (2019). doi:10.1074/jbc.RA118.006311
Journal of Biological Chemistry, 294(11), 3853-3871. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

The nonlysosomal glucosylceramidase β2 (GBA2) catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. Mutations in the human GBA2 gene have been associated with hereditary spastic paraplegia (HSP), autosomal-recessive cerebellar ataxia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d15045280ed8ce4c2e5661f40ffa912
https://doi.org/10.1074/jbc.ra118.006311

Author Correction: The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding

Autor: Florian Windler, Ulrich Benjamin Kaupp, Elena Grahn, Wolfgang Bönigk, Timo Strünker, Reinhard Seifert, Heinz G. Körschen

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5e66ba46639c3ccbb81a2d46795bf5
https://doi.org/10.1038/s41467-020-18023-5

A family of hyperpolarization-activated channels selective for protons

Autor: Lea Wobig, Reinhard Seifert, Heinz G. Körschen, Sylvia Fechner, Thomas K. Berger, U. Benjamin Kaupp, Jan F. Jikeli, Regina Feederle, Wolfgang Bönigk, Christian Trötschel, Thérèse Wolfenstetter

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance We discovered a subfamily of voltage-gated ion channels, called HCN-like channels, consisting of two members, HCNL1 and HCNL2. In contrast to classic pacemaker HCN channels in the heart and brain, HCNL1 conducts protons rather than potas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d4f4383f458393d4a05ff6920d390a
https://hdl.handle.net/21.11116/0000-0006-7C87-721.11116/0000-0007-640F-9