Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Autor: Mohamad K. Hammoud, Raimund Dietze, Jelena Pesek, Florian Finkernagel, Annika Unger, Tim Bieringer, Andrea Nist, Thorsten Stiewe, Aditya M. Bhagwat, Wolfgang Andreas Nockher, Silke Reinartz, Sabine Müller‐Brüsselbach, Johannes Graumann, Rolf Müller

Publikováno v: Molecular Oncology, Vol 16, Iss 17, Pp 3146-3166 (2022)

Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163highCD206high tumor‐associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations a

Externí odkaz: https://doaj.org/article/b07760c30d844b4981bdc57ee195b2a3

Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

Autor: Florian Finkernagel, Julia M. Jansen, Sabine Müller-Brüsselbach, Silke Reinartz, Johannes Graumann, Sonja Lieber, Alina Asafova, Anne Konzer, Thomas Worzfeld, Jelena Pesek, Uwe Wagner, Dominique T. Brandt, Wolfgang Andreas Nockher, Bernard Watzer, Andrea Nist, Robert Grosse, Thorsten Stiewe, Rolf Müller

Publikováno v: Molecular Oncology, Vol 13, Iss 2, Pp 185-201 (2019)
Molecular Oncology

The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) as a potentially crucial mediator. However, the origin of LPA in ascites and the clinical relevance of individual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b185c96092eb68d21313f1e49db6795d
https://doaj.org/article/e7b07ecf563740a58d0b49e54170b0d7

Determination of red blood cell fatty acid profiles: Rapid and high-confident analysis by chemical ionization-gas chromatography-tandem mass spectrometry

Autor: Yvonne Schober, Wolfgang Andreas Nockher, Hans Günther Wahl, Harald Renz

Publikováno v: Journal of Chromatography B. 1040:1-7

Cellular fatty acid (FA) profiles have been acknowledged as biomarkers in various human diseases. Nevertheless, common FA analysis by gas chromatography mass spectrometry (GC-MS) requires long analysis time. Hence, there is a need for feasible method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce866bde4d4749783503ec6586d2b77e
https://doi.org/10.1016/j.jchromb.2016.11.019

Serum uromodulin-a marker of kidney function and renal parenchymal integrity

Autor: Erik Ilsø Christensen, Matthias Block, Jürgen E. Scherberich, Hans Juergen Schmitt, Jürgen Kaden, Victor Herbst, Wolfgang Schlumberger, Wolfgang Andreas Nockher, Rudolf Gruber

Publikováno v: Scherberich, J E, Gruber, R, Nockher, W A, Christensen, E I, Schmitt, H, Herbst, V, Block, M, Kaden, J & Schlumberger, W 2018, ' Serum uromodulin-a marker of kidney function and renal parenchymal integrity ', Nephrology, Dialysis, Transplantation, vol. 33, no. 2, pp. 284-295 . https://doi.org/10.1093/ndt/gfw422
Nephrology Dialysis Transplantation

Background An ELISA to analyse uromodulin in human serum (sUmod) was developed, validated and tested for clinical applications. Methods We assessed sUmod, a very stable antigen, in controls, patients with chronic kidney disease (CKD) stages 1–5, pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3896886cd4292fcc19bd453b41fe42e5
https://pure.au.dk/portal/da/publications/serum-uromodulina-marker-of-kidney-function-and-renal-parenchymal-integrity(1872cc0c-66b7-4f72-af71-49a61b69a178).html

Plasma Uromodulin Correlates With Kidney Function and Identifies Early Stages in Chronic Kidney Disease Patients

Autor: Dominik, Steubl, Matthias, Block, Victor, Herbst, Wolfgang Andreas, Nockher, Wolfgang, Schlumberger, Robin, Satanovskij, Susanne, Angermann, Anna-Lena, Hasenau, Lynne, Stecher, Uwe, Heemann, Lutz, Renders, Jürgen, Scherberich

Publikováno v: Medicine

Uromodulin, released from tubular cells of the ascending limb into the blood, may be associated with kidney function. This work studies the relevance of plasma uromodulin as a biomarker for kidney function in an observational cohort of chronic kidney

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a48c5f365fd7fc4e8e11be11168822d7
https://pubmed.ncbi.nlm.nih.gov/26962815