Zobrazeno 1 - 10
of 449
pro vyhledávání: '"Wolfgang A. Schulz"'
Autor:
Ananda Ayyappan Jaguva Vasudevan, Michèle J. Hoffmann, Gereon Poschmann, Patrick Petzsch, Constanze Wiek, Kai Stühler, Karl Köhrer, Wolfgang A. Schulz, Günter Niegisch
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-7 (2022)
Measurement(s) RNA-seq assay • Proteome Technology Type(s) Whole Transcriptome Sequencing • Mass spectrometry intensity based label-free quantification method Factor Type(s) Effect of HDAC5 overexpression in a range of urothelial cancer cells Sam
Externí odkaz:
https://doaj.org/article/31a9b4a026c34b6694b497aa3c502bac
Autor:
Wardah Mahmood, Lars Erichsen, Pauline Ott, Wolfgang A. Schulz, Johannes C. Fischer, Marcos J. Arauzo-Bravo, Marcelo L. Bendhack, Mohamed Hassan, Simeon Santourlidis
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract LINE-1 hypomethylation of cell-free DNA has been described as an epigenetic biomarker of human aging. However, in the past, insufficient differentiation between cellular and cell-free DNA may have confounded analyses of genome-wide methylati
Externí odkaz:
https://doaj.org/article/9945070da77641ddb99a7d48f519ce43
Autor:
Madeleine Sassenberg, Johanna Droop, Wolfgang A. Schulz, Dimo Dietrich, Sophia Marie Loick, Constanze Wiek, Kathrin Scheckenbach, Nadine T. Gaisa, Michèle J. Hoffmann
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Few diagnostic and prognostic biomarkers are available for head-and-neck squamous cell carcinoma (HNSCC). Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases functionally contrib
Externí odkaz:
https://doaj.org/article/115d49ac3a2c49debea39eedcc596b40
Autor:
Wardah Mahmood, Lars Erichsen, Pauline Ott, Wolfgang A. Schulz, Johannes C. Fischer, Marcos J. Arauzo‑Bravo, Marcelo L. Bendhack, Mohamed Hassan, Simeon Santourlidis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/a7e237b7618a4ea1a8367934ad053fa6
Autor:
Simeon Santourlidis, Wolfgang A. Schulz, Marcos J. Araúzo-Bravo, Daniela Gerovska, Pauline Ott, Marcelo L. Bendhack, Mohamed Hassan, Lars Erichsen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1531 (2022)
Epigenetic mechanisms are fundamentally important for cancer initiation and development. However, a survey of the literature reveals that, to date, they appear less comprehensively investigated in melanoma than in many other cancers, e.g., prostate,
Externí odkaz:
https://doaj.org/article/8bfb3463682e4e5780df009e5249b8b8
Autor:
Aline Kaletsch, Maria Pinkerneil, Michèle J. Hoffmann, Ananda A. Jaguva Vasudevan, Chenyin Wang, Finn K. Hansen, Constanze Wiek, Helmut Hanenberg, Christoph Gertzen, Holger Gohlke, Matthias U. Kassack, Thomas Kurz, Wolfgang A. Schulz, Günter Niegisch
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-18 (2018)
Abstract Background Histone deacetylase inhibitors (HDACi) are promising anti-cancer drugs that could also be employed for urothelial carcinoma (UC) therapy. It is unclear, however, whether inhibition of all 11 zinc-dependent HDACs or of individual e
Externí odkaz:
https://doaj.org/article/e87d19bc77ef4eaa9cb7bb52c1e09692
Autor:
Lars Erichsen, Foued Ghanjati, Agnes Beermann, Cedric Poyet, Thomas Hermanns, Wolfgang A. Schulz, Hans-Helge Seifert, Peter J. Wild, Lorenz Buser, Alexander Kröning, Stefan Braunstein, Martin Anlauf, Silvia Jankowiak, Mohamed Hassan, Marcelo L. Bendhack, Marcos J. Araúzo-Bravo, Simeon Santourlidis
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Urothelial carcinoma (UC), the most common cancer of the urinary bladder causes severe morbidity and mortality, e.g. about 40.000 deaths in the EU annually, and incurs considerable costs for the health system due to the need for prolonged tr
Externí odkaz:
https://doaj.org/article/2c7f1dd5e43c455492ff4ecacd90cfcf
Autor:
Alexander S. Hölscher, Wolfgang A. Schulz, Maria Pinkerneil, Günter Niegisch, Michèle J. Hoffmann
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background New efficient therapies for urothelial carcinoma (UC) are urgently required. Small-molecule drugs targeting chromatin regulators are reasonable candidates because these regulators are frequently mutated or deregulated in UC. Indee
Externí odkaz:
https://doaj.org/article/afd75562c767409abec905e2e04a6cfb
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Macrophages and dendritic cells dominate early immune responses to lentiviruses. HIV-1 sensing by pathogen recognition receptors induces signaling cascades that culminate in type I alpha/beta interferon (IFN-α/β) induction. IFN-α/β signa
Externí odkaz:
https://doaj.org/article/c3924f0025a64596b5afd0d46b6f4860
Autor:
Patcharawalai Whongsiri, Wolfgang Goering, Tobias Lautwein, Christiane Hader, Günter Niegisch, Karl Köhrer, Michèle J. Hoffmann, Wolfgang A. Schulz
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9433 (2020)
Human genomes contain about 100,000 LINE-1 (L1) retroelements, of which more than 100 are intact. L1s are normally tightly controlled by epigenetic mechanisms, which often fail in cancer. In bladder urothelial carcinoma (UC), particularly, L1s become
Externí odkaz:
https://doaj.org/article/14303a44ee1a467981b2e9ea9f3852b9