Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Wolfgang Kuschinsky"'
Publikováno v:
International Journal of Biological Sciences, Vol 4, Iss 1, Pp 1-7 (2008)
Growth factors are currently evaluated as therapeutics in stroke and neurodegeneration. Besides direct neurotrophic effects, they promote proliferation, survival, and differentiation of both transplanted and endogenous neural precursor cells (NPCs).
Externí odkaz:
https://doaj.org/article/fa6edbff40d24ceaaa8f0abc4806294d
Publikováno v:
Neurochemical Research. 35:1635-1642
Several questions concerning the survival of isolated neurons and neuronal stem and progenitor cells (NPCs) have not been answered in the past: (1) If lactate is discussed as a major physiological substrate of neurons, do neurons and NPCs survive in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbeda3c5b57d71012d0f91e71d548002
https://doi.org/10.1007/s11064-010-0224-1
https://doi.org/10.1007/s11064-010-0224-1
Publikováno v:
European Journal of Anaesthesiology. 26:245-252
BACKGROUND AND OBJECTIVE Under physiological conditions, cerebral oxygen delivery is kept constant by adaptation of the regional cerebral blood flow (CBF) in relation to the oxygen content. So far, decreases of the regional CBF induced by a higher ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71b1d13743903d4496a84b68a2be941
https://doi.org/10.1097/eja.0b013e328324b76b
https://doi.org/10.1097/eja.0b013e328324b76b
Autor:
Martin H. Maurer, Heinrich F. Bürgers, Carola Krüger, Bach Alfred, Dominik W. Schelshorn, Wolfgang Kuschinsky, Tanjew Dittgen, Armin Schneider, Fatemeh Sabouri, Nikolaus Gassler, Daniela Weber
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 29:585-595
Hemoglobin is the major protein in red blood cells and transports oxygen from the lungs to oxygen-demanding tissues, like the brain. Mechanisms that facilitate the uptake of oxygen in the vertebrate brain are unknown. In invertebrates, neuronal hemog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f36229b70fd461d75530a9bea124e46
https://doi.org/10.1038/jcbfm.2008.152
https://doi.org/10.1038/jcbfm.2008.152
Publikováno v:
The Open Enzyme Inhibition Journal. 1:5-11
Lithium is one of the standard drugs in the treatment of bipolar disorder, although its molecular modes of ac- tion are not well understood. It is a potent inhibitor of the multifunctional enzyme Glycogen Synthase Kinase 3s (GSK3s), which also plays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7e27188a1a997c700c85bf51502f826
https://doi.org/10.2174/1874940200801010005
https://doi.org/10.2174/1874940200801010005
Autor:
Martin H. Maurer, Klaus F. Waschke, Jochen Hinkelbein, Armin Kalenka, Robert E. Feldmann, Wolfgang Kuschinsky
Publikováno v:
Anesthesia & Analgesia. 104:1129-1135
BACKGROUND: Recent studies showed changes in cerebral protein expression up to 3 days after desflurane anesthesia in rats. In the present study, we investigated the existence of persisting changes on the proteome level after sevoflurane anesthesia th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626973b42743ee3b383b534acc31f15b
https://doi.org/10.1213/01.ane.0000260799.37107.e6
https://doi.org/10.1213/01.ane.0000260799.37107.e6
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 27:1675-1683
A major complication of aneurysmal subarachnoid hemorrhage (SAH) is symptomatic vasospasm, a complex syndrome consisting of neurological deterioration and exclusion of other sources of ischemia. Approximately 30% of SAH patients are affected. Althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485d29b498c5b3f2fc07d27c37349a22
https://doi.org/10.1038/sj.jcbfm.9600466
https://doi.org/10.1038/sj.jcbfm.9600466
Autor:
Helmut Schroeck, Jochen Hinkelbein, Charlotte Schubert, Wolfgang Kuschinsky, Anna Peterka, Armin Kalenka
Publikováno v:
Current Neurovascular Research. 4:39-47
Sepsis is often complicated by encephalopathy, neuroendocrine dysfunction and cardiovascular autonomic failure. The cause of septic brain dysfunction is not fully understood. The aim of the present study is to explore whether septic brain dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc40b02b53d246be85a5dd5cccc28c0b
https://doi.org/10.2174/156720207779940671
https://doi.org/10.2174/156720207779940671
Autor:
Wolfgang Kuschinsky, H. Kenny Geomor, Dominik W. Schelshorn, Martin H. Maurer, Heinrich F. Bürgers
Publikováno v:
FEBS Letters. 580:4430-4434
In the brain, glucose is transported by GLUT1 across the blood–brain barrier and into astrocytes, and by GLUT3 into neurons. In the present study, the expression of GLUT1 and GLUT3 mRNA and protein was determined in adult neural stem cells cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1691719ebc5ce1252a6f522f1342f5
https://doi.org/10.1016/j.febslet.2006.07.012
https://doi.org/10.1016/j.febslet.2006.07.012
Autor:
Michael Daffertshofer, Wolfgang Kuschinsky, Margherita Popolo, Zhihong Huang, Helmut Schroeck, Michael G. Hennerici, Michael A. Moskowitz, M. Fatar
Publikováno v:
Neuroscience Letters. 361:115-119
The key goal in the treatment of acute ischemic stroke is fast vessel recanalization. Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is efficient in humans but mean time for recanalization is within hours. Ultrasound bio-effects h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b660facad548d349b45389d5095fd90
https://doi.org/10.1016/j.neulet.2004.02.003
https://doi.org/10.1016/j.neulet.2004.02.003