Childhood PFAS exposure and immunotoxicity: a systematic review and meta-analysis of human studies

Autor: Evangelia E. Antoniou, Wolfgang Dekant

Publikováno v: Systematic Reviews, Vol 13, Iss 1, Pp 1-12 (2024)

Abstract Background Exposure to poly- and perfluoroalkyl substances (PFAS) may affect infant and childhood health through immunosuppression. However, the findings of epidemiological literature examining relationships between prenatal/childhood PFAS e

Externí odkaz: https://doaj.org/article/f45bd656171f4f759e3928a8b47a874a

Commentary: cumulative risk assessment of perfluoroalkyl carboxylic acids and perfluoralkyl sulfonic acids: what is the scientific support for deriving tolerable exposures by assembling 27 PFAS into 1 common assessment group?

Autor: Thomas Colnot, Wolfgang Dekant

Publikováno v: Archives of Toxicology. 96:3127-3139

This commentary proposes an approach to risk assessment of mixtures of per- and polyfluorinated alkyl substances (PFAS) as EFSA was tasked to derive a tolerable intake for a group of 27 PFAS. The 27 PFAS to be considered contain different functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5dfd96fe4041f1a6869c7212225b1d
https://doi.org/10.1007/s00204-022-03336-9

Evaluation of animal toxicity studies with diisocyanates regarding presence of thresholds for induction and elicitation of respiratory allergy by quantitative weight of evidence

Autor: Wolfgang Dekant, Thomas Colnot

Publikováno v: Toxicology and Industrial Health. 38:578-594

Animal toxicity studies on diisocyanates were evaluated using quantitative weight of evidence (QWoE) to test the hypothesis that the dose-response curve shows a threshold for the induction and/or elicitation of respiratory sensitization. A literature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6caf28d40d713eec3802b176370b0bd
https://doi.org/10.1177/07482337211069234

Issues in the inhalation toxicity testing and hazard assessment for low density particulate materials such as synthetic amorphous silica (SAS)

Autor: Wolfgang Dekant, Evangelia E. Antoniou, Axel Bosch, Gustav Gerd Bruer, Thomas Colnot, Otto Creutzenberg, Claus-Peter Drexel, Rodger Duffin, Nils Krueger, Jürgen Nolde, Craig Poland, Dirk Schaudien, Tobias B. Schuster, Michael Stintz, Klaus Weber, Benno Wessely, Maurice P. Zeegers

Inhalation toxicity testing of particulate materials is mandated for classification. According to CLP, particulate materials should be tested as marketed and many particulate materials are marketed as non-respirable particles. However, OECD TG 413 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29f235c635571622d64b154c647be03
https://publica.fraunhofer.de/handle/publica/439571

The EU chemicals strategy for sustainability: in support of the BfR position

Autor: H. M. Bolt, Helmut Greim, Christopher J. Borgert, Daniel R. Dietrich, Emanuela Testai, Pat Heslop-Harrison, Hans Marquardt, Alan R. Boobis, Olavi Pelkonen, Bas J. Blaauboer, Angela Mally, Gio Batta Gori, Sam Kacew, Corrado L. Galli, Jan G. Hengstler, José L. Domingo, Wolfgang Dekant, Kai Savolainen, Nico P. E. Vermeulen, Sir Colin Berry, Frank A. Barile, Aristides M. Tsatsakis

Publikováno v: Barile, F A, Berry, S C, Blaauboer, B, Boobis, A, Bolt, H M, Borgert, C, Dekant, W, Dietrich, D, Domingo, J L, Galli, C L, Gori, G B, Greim, H, Hengstler, J G, Heslop-Harrison, P, Kacew, S, Marquardt, H, Mally, A, Pelkonen, O, Savolainen, K, Testai, E, Tsatsakis, A & Vermeulen, N P 2021, ' The EU chemicals strategy for sustainability: in support of the BfR position ', Archives of Toxicology, vol. 95, no. 9, pp. 3133-3136 . https://doi.org/10.1007/s00204-021-03125-w
Archives of Toxicology, 95(9), 3133-3136. Springer Verlag
Archives of Toxicology

The EU chemicals strategy for sustainability (CSS) asserts that both human health and the environment are presently threatened and that further regulation is necessary. In a recent Guest Editorial, members of the German competent authority for risk a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ad0be09ff46e7e756735a6b53133a5
https://doi.org/10.1007/s00204-021-03125-w