Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Wolfgang, Wohlleben"'
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Lysolipin I is a halogenated, polycyclic xanthone natural product belonging to the polyketide class of antibiotics, naturally produced by Streptomyces violaceoniger TÜ96 and Streptomyces tendae TÜ4042. The biosynthesis is encoded on a 43 kb-spannin
Externí odkaz:
https://doaj.org/article/4b28042f52f84efa8d353e4bdf2c94cb
Autor:
Sergii Krysenko, Wolfgang Wohlleben
Publikováno v:
Microorganisms, Vol 12, Iss 8, p 1571 (2024)
The natural soil environment of Streptomyces is characterized by variations in the availability of nitrogen, carbon, phosphate and sulfur, leading to complex primary and secondary metabolisms. Their remarkable ability to adapt to fluctuating nutrient
Externí odkaz:
https://doaj.org/article/252e4cf7cb1744a5a875a0e249a1fc91
Autor:
Linda Jahn, Lisa Storm-Johannsen, Diana Seidler, Jasmin Noack, Wei Gao, Thomas Schafhauser, Wolfgang Wohlleben, Willem J. H. van Berkel, Philippe Jacques, Tambi Kar, Birgit Piechulla, Jutta Ludwig-Müller
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 35, Iss 1, Pp 49-63 (2022)
Cyanodermella asteris is a fungal endophyte from Aster tataricus, a perennial plant from the northern part of Asia. Here, we demonstrated an interaction of C. asteris with Arabidopsis thaliana, Chinese cabbage, rapeseed, tomato, maize, or sunflower r
Externí odkaz:
https://doaj.org/article/e872aaaeaef44126b5d2d3905935057b
Autor:
Susann Schulz, Christoph Schall, Thilo Stehle, Christian Breitmeyer, Sergii Krysenko, Agnieszka Mitulski, Wolfgang Wohlleben
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Tacrolimus (FK506) is a macrolide widely used as immunosuppressant to prevent transplant rejection. Synthetic production of FK506 is not efficient and costly, whereas the biosynthesis of FK506 is complex and the level produced by the wild type strain
Externí odkaz:
https://doaj.org/article/096f27afd2ae4dfd99fa4e7826c58555
Autor:
Valentina Goldfinger, Marius Spohn, Jens-Peter Rodler, Melanie Sigle, Andreas Kulik, Max J. Cryle, Johanna Rapp, Hannes Link, Wolfgang Wohlleben, Evi Stegmann
Publikováno v:
Metabolic Engineering. 78:84-92
Autor:
Thomas Schafhauser, Daniel Wibberg, Antonia Binder, Christian Rückert, Tobias Busche, Wolfgang Wohlleben, Jörn Kalinowski
Publikováno v:
Journal of Fungi, Vol 8, Iss 8, p 862 (2022)
The gilled mushroom Clitopilus passeckerianus (Entolomataceae, Agaricales, Basidiomycota) is well known to produce the terpenoid pleuromutilin, which is the biotechnological basis for medically important antibiotics such as lefamulin and retapamulin.
Externí odkaz:
https://doaj.org/article/5650cbf4774948a29d78f1c16888bc66
Autor:
Sergii Krysenko, Wolfgang Wohlleben
Publikováno v:
Medical Sciences, Vol 10, Iss 3, p 40 (2022)
Nitrogen is an essential element required for bacterial growth. It serves as a building block for the biosynthesis of macromolecules and provides precursors for secondary metabolites. Bacteria have developed the ability to use various nitrogen source
Externí odkaz:
https://doaj.org/article/373ff41aa97446afb296c4e2218f9b4a
Autor:
Susann Schulz, Håvard Sletta, Kristin Fløgstad Degnes, Sergii Krysenko, Alicia Williams, Silje Malene Olsen, Kai Vernstad, Agnieszka Mitulski, Wolfgang Wohlleben
Publikováno v:
Applied Microbiology and Biotechnology. 107:2871-2886
Abstract FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological production of FK-506 is
Autor:
Sergii Krysenko, Nicole Okoniewski, Merle Nentwich, Arne Matthews, Moritz Bäuerle, Alina Zinser, Tobias Busche, Andreas Kulik, Stephanie Gursch, Annika Kemeny, Agnieszka Bera, Wolfgang Wohlleben
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3752 (2022)
Streptomyces coelicolor is a soil bacterium living in a habitat with very changeable nutrient availability. This organism possesses a complex nitrogen metabolism and is able to utilize the polyamines putrescine, cadaverine, spermidine, and spermine a
Externí odkaz:
https://doaj.org/article/baf3e8e842484ce199d17edbdb642cb4
Publikováno v:
Synthetic and Systems Biotechnology, Vol 3, Iss 1, Pp 56-63 (2018)
The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action, high potency and reduced toxicity compared to today's standard drugs. However, production of brasilicardin has been hampered since the producer str
Externí odkaz:
https://doaj.org/article/32f9447e534e4a0891154e9df9e9ac3d