Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures

Autor: Johannes Laengle, Julijan Kabiljo, Jakob Homola, Gerda Egger, Michael Bergmann, Wolfgang Weninger, Matthias Farlik, Askin Kulu, Anna Theophil, Annalena F Renner, Nathalie Stürzenbecher, Daphni Ammon, Rebecca Zirnbauer, Simone Stang, Loan Tran, Anna Chen, Markus Fabits, Velina S Atanasova, Oliver Pusch, Henning Walczak, Dietmar Herndler Brandstetter, Helmut Dolznig, Anna Kusienicka

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)

Background Patient-derived colorectal cancer (CRC) organoids (PDOs) solely consisting of malignant cells led to major advances in the understanding of cancer treatments. Yet, a major limitation is the absence of cells from the tumor microenvironment,

Externí odkaz: https://doaj.org/article/43d139dea126402b8e4adf40bf531087

Regulation of the Immune Cell Repertoire in Psoriasis Patients Upon Blockade of IL-17A or TNFα

Autor: Julia Tittes, Jennifer Brell, Pia Fritz, Constanze Jonak, Georg Stary, Julia M. Ressler, Sarojinidevi Künig, Wolfgang Weninger, Johannes Stöckl

Publikováno v: Dermatology and Therapy, Vol 14, Iss 3, Pp 613-626 (2024)

Abstract Introduction Targeting of the proinflammatory cytokine interleukin 17A (IL-17A) or tumor necrosis factor alpha (TNFα) with the monoclonal antibodies (mAbs) ixekizumab or adalimumab, respectively, is a successful therapy for chronic plaque p

Externí odkaz: https://doaj.org/article/1982e8e7427a46c08cefd62752877802

Comparison of humans versus mobile phone-powered artificial intelligence for the diagnosis and management of pigmented skin cancer in secondary care: a multicentre, prospective, diagnostic, clinical trial

Autor: Scott W Menzies, ProfPhD, Christoph Sinz, MD, Michelle Menzies, BSc, Serigne N Lo, PhD, William Yolland, BSc, Johann Lingohr, BSc, Majid Razmara, PhD, Philipp Tschandl, PhD, Pascale Guitera, ProfPhD, Richard A Scolyer, ProfMD, Florentina Boltz, MD, Liliane Borik-Heil, MD, Hsien Herbert Chan, MD, David Chromy, MD, David J Coker, MD, Helena Collgros, MD, Maryam Eghtedari, MD, Marina Corral Forteza, MD, Emily Forward, MD, Bruna Gallo, MD, Stephanie Geisler, MD, Matthew Gibson, MMed, Amelie Hampel, MD, Genevieve Ho, MD, Laura Junez, MD, Philipp Kienzl, PhD, Arthur Martin, MD, Fergal J Moloney, MD, Amanda Regio Pereira, MD, Julia Maria Ressler, MD, Susanne Richter, MD, Katharina Silic, MD, Thomas Silly, MD, Michael Skoll, MD, Julia Tittes, MD, Philipp Weber, MD, Wolfgang Weninger, ProfPhD, Doris Weiss, MD, Ping Woo-Sampson, MD, Catherine Zilberg, MD, Harald Kittler, MD

Publikováno v: The Lancet: Digital Health, Vol 5, Iss 10, Pp e679-e691 (2023)

Summary: Background: Diagnosis of skin cancer requires medical expertise, which is scarce. Mobile phone-powered artificial intelligence (AI) could aid diagnosis, but it is unclear how this technology performs in a clinical scenario. Our primary aim w

Externí odkaz: https://doaj.org/article/bb536ef03af64214ad529982414e2889

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Autor: Matthias Wielscher, Pooja R. Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P. Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E. Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M. Psaty, Marie Loh, Joshua C. Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J. Deary, Marc Chadeau-Hyam, Jennifer A. Brody, Alexia Cardona, Elizabeth Selvin, Alicia K. Smith, Andrew H. Miller, Mylin A. Torres, Eirini Marouli, Xin Gào, Joyce B. J. van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao Zhang, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J. Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L. Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A. Hurme, Olli T. Raitakari, Elena Colicino, Andrea A. Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, BIOS consortium, Karen N. Conneely, Jaspal S. Kooner, Anna Köttgen, Bastiaan T. Heijmans, Panos Deloukas, Caroline Relton, Ken K. Ong, Jordana T. Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C. Chambers, Abbas Dehghan, Marjo-Riitta Järvelin

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive protein levels and find t

Externí odkaz: https://doaj.org/article/715a1a2d6b1f44f19a7bcf745876ed05

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma

Autor: Katharina Rindler, Constanze Jonak, Natalia Alkon, Felix M. Thaler, Harald Kurz, Lisa E. Shaw, Georg Stingl, Wolfgang Weninger, Florian Halbritter, Wolfgang M. Bauer, Matthias Farlik, Patrick M. Brunner

Publikováno v: Molecular Cancer, Vol 20, Iss 1, Pp 1-23 (2021)

Abstract Background In early-stage mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, limited skin involvement with patches and plaques is associated with a favorable prognosis. Nevertheless, approximately 20–30% of cases pr

Externí odkaz: https://doaj.org/article/2720d6bc4c23482a912b316fd2254e83