Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Wolfgang, Skranc"'
Autor:
Wolfgang Skranc, Daniel Lumpi, Barbara Pokorny, Johannes Fröhlich, Rene Klaffenböck, Brigitte Holzer, Paul Kautny, Viktor Carl, Berthold Stöger, Ernst Horkel, Christian Hametner
Publikováno v:
European Journal of Organic Chemistry. 2018:4600-4613
Autor:
Daniel Marchal, Simone Tortoioli, Martin Kesselgruber, Wolfgang Skranc, Thomas Pabst, Stefan Abele
Publikováno v:
Organic Process Research & Development. 18:1759-1762
A three-step fully telescoped synthesis of an N-sulfonyl proline amide, a nonpeptide antagonist of human orexin receptors, is described. The process development from the medicinal chemistry route up to the 240 kg production of 1 is discussed with a f
Autor:
Wolfgang Skranc, Peter Poechlauer
Publikováno v:
Sustainable Flow Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f39392e89b341cba6123d1e4640cf03
https://doi.org/10.1002/9783527689118.ch4
https://doi.org/10.1002/9783527689118.ch4
Autor:
Juergen Stichler, Peter Kapitan, Laurent Lefort, Richard A. Ward, Thomas Dax, Stefan Abele, Johannes G. de Vries, André H.M. de Vries, Gerard K. M. Verzijl, Wolfgang Skranc, Matthias Helms, Zarghun Nazir, Imboden Christoph
Publikováno v:
Organic Process Research & Development. 17:1531-1539
Several methods are presented for the enantioselective synthesis of the tetrahydroisoquinoline core of almorexant (ACT-078573A), a dual orexin receptor antagonist. Initial clinical supplies were secured by the Noyori Ru-catalyzed asymmetric transfer
Autor:
Mario Waser, Wolfgang Skranc, Hans Fierz, Wolfgang Schiek, John Matthias Wiegand, Roland Obermüller
Publikováno v:
Organic Process Research & Development. 14:562-567
2-(Pyridin-2-ylmethanesulfinyl)-1H-benzimidazole-based drugs belong to the most prominent and successfully applied proton pump inhibitors. To fulfill the demand for a flexible and safe procedure for the synthesis of early-stage intermediates which ar
Autor:
Zhibin Liu, Manuela Avi, Richard Gaisberger, Anton Glieder, Karl Gruber, Wolfgang Skranc, Beate Pscheidt, Herfried Griengl
Publikováno v:
Advanced Synthesis & Catalysis. 350:1943-1948
Screening for stereoselective cyanohydrin synthesis in 96-well plates was employed in the development of an efficient, pH-stable hydroxynitrile lyase for the conversion of sterically hindered aliphatic aldehydes. Site-saturation mutagenesis (SSM) res
Autor:
Richard Gaisberger, Franz Stefan Hartner, Manuela Avi, Anton Glieder, Wolfgang Skranc, Beate Pscheidt
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. :183-188
The application of (R)-hydroxynitrile lyases ((R)-HNLs) enables a simple chemo-enzymatic approach towards (R)-pantolactone synthesis. For the first time, several new recombinant almond (R)-HNL isoenzymes were compared with native HNLs from different
Autor:
Richard Gaisberger, Zhibin Liu, Beate Pscheidt, Karl Gruber, Franz Stefan Hartner, Manuela Avi, Christian Schuster, Anton Glieder, Wolfgang Skranc
Publikováno v:
ChemBioChem. 9:58-61
Publikováno v:
Applied Microbiology and Biotechnology. 76:309-320
The application of hydroxynitrile lyases (HNLs) as catalysts for the stereoselective condensation of HCN with carbonyl compounds has been reported as early as 1908. This enzymatic C-C bond coupling reaction furnishes enantiopure cyanohydrins which se
Publikováno v:
Advanced Synthesis & Catalysis. 349:1445-1450
The hydroxynitrile lyase from Hevea brasi- liensis not only catalyzes - according to the natural activity of this enzyme - the formation and cleavage of cyanohydrins but also the reaction of nitroalkanes with aldehydes (Henry reaction). This is the f