Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Autor: Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz, Vicki Stone

Publikováno v: Particle and Fibre Toxicology, Vol 16, Iss 1, Pp 1-14 (2019)

Abstract Background With ever-increasing exposure to engineered nanomaterials (NMs), there is an urgent need to evaluate the probability of consequential adverse effects. The potential for NM translocation to distal organs is a realistic prospect, wi

Externí odkaz: https://doaj.org/article/83dca219ba974b5fa13e47d30338591d

A Model‐Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs

Autor: Ramona Nudischer, Adrian Roth, Vanessa Baier, Lars M. Blank, José V. Castell, Jens M. Kelm, Annika R. P. Schneider, Florian Caiment, Hans Gmuender, Christoph Thiel, Lars Kuepfer, Wolfgang Moritz, Yannick Schrooders, Henrik Cordes, Jos C. S. Kleinjans, Christian Trautwein, Timo Wittenberger, Olivia Clayton, Ulf P. Neumann

Publikováno v: Clinical pharmacology & therapeutics : CPT 110(5), 1293-1301 (2021). doi:10.1002/cpt.2406
Clinical Pharmacology & Therapeutics, 110(5), 1293-1301. Wiley
CLINICAL PHARMACOLOGY & THERAPEUTICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

We present a generic workflow combining physiology-based computational modeling and in vitro data to assess the clinical cholestatic risk of different drugs systematically. Changes in expression levels of genes involved in the enterohepatic circulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bb897e70f87a57b55a2225fb471753
https://doi.org/10.1002/cpt.2406

Tracing Clonal Dynamics Reveals that Two- and Three-dimensional Patient-derived Cell Models Capture Tumor Heterogeneity of Clear Cell Renal Cell Carcinoma

Autor: Jack Kuipers, Holger Moch, Peter K. Bode, Niko Beerenwinkel, Francesca Chiovaro, Markus Rechsteiner, Chantal Pauli, Abdullah Kahraman, Viktor H. Koelzer, Claudia Corrò, Nora C. Toussaint, Wolfgang Moritz, Peter Schraml, Adriana von Teichman, Hella A. Bolck

Publikováno v: European Urology Focus, 7 (1)

Background Extensive DNA sequencing has led to an unprecedented view of the diversity of individual genomes and their evolution among patients with clear cell renal cell carcinoma (ccRCC). Objective To understand subclonal architecture and dynamics o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a5fbe020a3aac4e61d1824a36d8abd
https://doi.org/10.1016/j.euf.2019.06.009

Abstract 4558: High-throughput, high content Imaging assay for assessing solid tumor phagocytosis in 3D spheroid model

Autor: Michal Rudnik, Özlem Yavaş Grining, Nadezhda Rotankova, Silvan Strebel, Francesca Chiovaro, Olivier Frey, Irina Agarkova, Wolfgang Moritz

Publikováno v: Cancer Research. 83:4558-4558

Emerging studies have demonstrated that innate immune checkpoints, regulating Tumor-associated Macrophage (TAM) phagocytic activity, play a crucial role in immune escape and survival of cancer cells. CD47-SIRPα axis is the best studied example of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::449cc6bb210f3bc39737170109515bee
https://doi.org/10.1158/1538-7445.am2023-4558

Cell-Cell Contact Formation Governs Ca2+ Signaling by TRPC4 in the Vascular Endothelium: EVIDENCE FOR A REGULATORY TRPC4-β-CATENIN INTERACTION

Autor: Graziani, Annarita, Poteser, Michael, Heupel, Wolfgang-Moritz, Schleifer, Hannes, Krenn, Martin, Drenckhahn, Detlev, Romanin, Christoph, Baumgartner, Werner, Groschner, Klaus

Publikováno v: In Journal of Biological Chemistry 5 February 2010 285(6):4213-4223