Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Wolfgang, Kummer"'
Autor:
Maryam Keshavarz, Anna-Lena Ruppert, Mirjam Meiners, Krupali Poharkar, Shuya Liu, Wafaa Mahmoud, Sarah Winterberg, Petra Hartmann, Petra Mermer, Alexander Perniss, Stefan Offermanns, Wolfgang Kummer, Burkhard Schütz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Disorders of gallbladder motility can lead to serious pathology. Bitter tastants acting upon bitter taste receptors (TAS2R family) have been proposed as a novel class of smooth muscle relaxants to combat excessive contraction in the airways
Externí odkaz:
https://doaj.org/article/321211e0cffc423699dcbf34241b5d02
Autor:
Alexander Perniss, Nadine Schmidt, Corinne Gurtner, Kristina Dietert, Oliver Schwengers, Markus Weigel, Julia Hempe, Christa Ewers, Uwe Pfeil, Ulrich Gärtner, Achim D. Gruber, Torsten Hain, Wolfgang Kummer
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Several species of the Gram-negative genus Bordetella are the cause of respiratory infections in mammals and birds, including whooping cough (pertussis) in humans. Very recently, a novel atypical species, Bordetella pseudohinzii, was isolate
Externí odkaz:
https://doaj.org/article/a4e38a4616c9419092e411bc2705df3d
Publikováno v:
Pulmonary Circulation, Vol 8 (2018)
We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices.
Externí odkaz:
https://doaj.org/article/8bed3083588f47538107238a87d68b2f
Autor:
Chrissy Kandel, Patricia Schmidt, Alexander Perniss, Maryam Keshavarz, Paul Scholz, Sabrina Osterloh, Mike Althaus, Wolfgang Kummer, Klaus Deckmann
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Cholinergic polymodal chemosensory cells in the mammalian urethra (urethral brush cells = UBC) functionally express the canonical bitter and umami taste transduction signaling cascade. Here, we aimed to determine whether UBC are functionally equipped
Externí odkaz:
https://doaj.org/article/1cd1411079e24ffc964889ba81f265c3
Autor:
Magdalena Chottova Dvorakova, Eliska Mistrova, Renate Paddenberg, Wolfgang Kummer, Jana Slavikova
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Substance P (SP) is a neuropeptide engaged in the signal transmission of neural C fibers afferents in the myocardium. The actions of SP in the heart are extensive and they are mediated by the neurokinin 1 receptor (NK1R), a member of the tachykinin s
Externí odkaz:
https://doaj.org/article/a7380fdd322646a2aabf45b3131fc0ef
Autor:
Katrin Richter, Sabrina Sagawe, Andreas Hecker, Mira Küllmar, Ingolf Askevold, Jelena Damm, Sarah Heldmann, Michael Pöhlmann, Sophie Ruhrmann, Michael Sander, Klaus-Dieter Schlüter, Sigrid Wilker, Inke R. König, Wolfgang Kummer, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, Anna Teresa Zakrzewicz, Christian Koch, Veronika Grau
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Blood levels of the acute phase reactant C-reactive protein (CRP) are frequently measured as a clinical marker for inflammation, but the biological functions of CRP are still controversial. CRP is a phosphocholine (PC)-binding pentraxin, mainly produ
Externí odkaz:
https://doaj.org/article/5e2707b530894516b8c0f1772f70b0da
Autor:
Andreas Hoek, Aichurek Soultanova, Wolfgang Kummer, Krupali V. Poharkar, Sudhanshu Bhushan, Uwe Pfeil, Alexander Perniss, Ulrich Gärtner, Wafaa Mahmoud, Torsten Hain
Publikováno v:
Cell and Tissue Research. 390:35-49
The conducting airways are lined by distinct cell types, comprising basal, secretory, ciliated, and rare cells, including ionocytes, solitary cholinergic chemosensory cells, and solitary and clustered (neuroepithelial bodies) neuroendocrine cells. Ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c3e527bfb0b3cbef8b1f3f2d938596
https://doi.org/10.1007/s00441-021-03552-2
https://doi.org/10.1007/s00441-021-03552-2
Autor:
Olena Lykhmus, Larysa P. Voytenko, Katrin S. Lips, Ivonne Bergen, Gabriela Krasteva-Christ, Douglas E. Vetter, Wolfgang Kummer, Maryna Skok
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are likely to be the evolutionary precursors to the entire cys-loop superfamily of ligand-gated ion channels, which includes acetylcholine, GABA, glycine and serotonin ionotropic rece
Externí odkaz:
https://doaj.org/article/5abc488d17c14f7bb7bdd23ad15206cb
Autor:
Maryam Keshavarz, Heike Schwarz, Petra Hartmann, Silke Wiegand, Melanie Skill, Mike Althaus, Wolfgang Kummer, Gabriela Krasteva-Christ
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
An increased bronchoconstrictor response is a hallmark in the progression of obstructive airway diseases. Acetylcholine and 5-hydroxytryptamine (5-HT, serotonin) are the major bronchoconstrictors. There is evidence that both cholinergic and serotoner
Externí odkaz:
https://doaj.org/article/8b56361c8a5f4cef8a4a9d9589f948db
Autor:
Ghulam Murtaza, Petra Mermer, Anna Goldenberg, Uwe Pfeil, Renate Paddenberg, Nobert Weissmann, Guenter Lochnit, Wolfgang Kummer
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174071 (2017)
The two-pore domain potassium channel KCNK3 (TASK-1) is expressed in rat and human pulmonary artery smooth muscle cells. There, it is associated with hypoxia-induced signalling, and its dysfunction is linked to pathogenesis of human pulmonary hyperte
Externí odkaz:
https://doaj.org/article/d3959ece44ec465bb3c9d8878b7f3ad0