Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Wolfgang, Kastenmüller"'
Autor:
Hao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein, Gabriela F. Gubert, Konrad Knöpper, Ana Maria Mansilla, Arman Öner, Remi Doucet-Ladevèze, Werner Schmitz, Bart Ghesquière, Sebastian Theurich, Jan Dudek, Georg Gasteiger, Alma Zernecke, Sebastian Kobold, Wolfgang Kastenmüller, Martin Vaeth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precu
Externí odkaz:
https://doaj.org/article/8569ec630ff141898b05f8e21eb43d82
Autor:
Tassnim Abdelwahab, David Stadler, Konrad Knöpper, Panagiota Arampatzi, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller, Rudolf Martini, Janos Groh
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106698- (2023)
Summary: Myelin defects lead to neurological dysfunction in various diseases and in normal aging. Chronic neuroinflammation often contributes to axon-myelin damage in these conditions and can be initiated and/or sustained by perturbed myelinating gli
Externí odkaz:
https://doaj.org/article/47495b32272d46e79ea05d00e9aeda7d
Autor:
Tassnim Abdelwahab, David Stadler, Konrad Knöpper, Panagiota Arampatzi, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller, Rudolf Martini, Janos Groh
SummaryMyelin defects lead to neurological dysfunction in various diseases and in normal aging. Chronic neuroinflammation often contributes to axon-myelin damage in these conditions and can be initiated and/or sustained by perturbed myelinating glia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc4136982b521cff31db324470b1d60
https://doi.org/10.1101/2023.01.10.523231
https://doi.org/10.1101/2023.01.10.523231
Autor:
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S. Gabriel, Wolfgang Kastenmüller, Christian Kurts, Sarah L. Londrigan, Axel Kallies, Katherine Kedzierska, Paul J. Hertzog, Eicke Latz, Yu-Chen E. Chen, Kristen J. Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E. Sander, Birgit Sawitzki, Joachim L. Schultze, Susanne V. Schmidt, Sammy Bedoui
Publikováno v:
Nature immunology 24(6), 979-990 (2023). doi:10.1038/s41590-023-01517-x
Antiviral CD8+ T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interferon-α/interferon-β (IF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fa2efef3db05d38b32977cd1c0284b
Autor:
Thomas Tüting, Bastian Kruse, Anthony Buzzai, Naveen Shridhar, Andreas Braun, Susan Gellert, Kristin Knauth, Johannes Peters, Janne Ruotsalainen, Miriam Mengoni, Tetje van der Sluis, Anna Krone, Di Yu, Simon Höhn, Yan Fu, Magnus Essand, Robert Geffers, Dimitrios Mougiakakos, Sascha Kahlfuß, Hamid Kashkar, Evelyn Gaffal, Wolfgang Kastenmüller, Andreas Müller
Current clinically applied cancer immunotherapies largely focus on the ability of CD8+ cytolytic T-cells to directly recognise and kill tumour cells1–3. These strategies are limited by the emergence of MHC-I-deficient or IFN-unresponsive tumour cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a329545a700588af826c3424469b29c
https://doi.org/10.21203/rs.3.rs-1764653/v1
https://doi.org/10.21203/rs.3.rs-1764653/v1
Autor:
Jan P. Böttcher, Oliver Schanz, Christoph Garbers, Anne Zaremba, Silke Hegenbarth, Christian Kurts, Marc Beyer, Joachim L. Schultze, Wolfgang Kastenmüller, Stefan Rose-John, Percy A. Knolle
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1318-1327 (2014)
Immune control of infections with viruses or intracellular bacteria relies on cytotoxic CD8+ T cells that use granzyme B (GzmB) for elimination of infected cells. During inflammation, mature antigen-presenting dendritic cells instruct naive T cells w
Externí odkaz:
https://doaj.org/article/1faa4c3286d149e591e9d48f7f359528
Autor:
Rudolf Martini, Janos Groh, Panagiota Arampatzi, Konrad Knöpper, Lena Lößlein, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller, Xidi Yuan
Publikováno v:
Nature Aging. 1:357-367
Aging is a major risk factor for the development of nervous system functional decline, even in the absence of diseases or trauma. The axon–myelin units and synaptic terminals are some of the neural structures most vulnerable to aging-related deteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e39c13b8ac74bf04d7cd1d7feb357cdc
https://doi.org/10.1038/s43587-021-00049-z
https://doi.org/10.1038/s43587-021-00049-z
Autor:
Marco Ataíde, Wolfgang Kastenmüller
Publikováno v:
eLife, Vol 5 (2016)
The factors that regulate how immune cells called innate-like lymphocytes are localized in the tissue have been identified.
Externí odkaz:
https://doaj.org/article/738420eecf8847df946a80e3c6254e31
Autor:
Martin Vaeth, Marco A. Ataide, Justus Weber, Hao Wu, Georg Gasteiger, Axel Kallies, Wolfgang Kastenmüller, Sarah Eickhoff, Anika Grafen, Natalio Garbi, Michael Hölzel, Tea Gogishvili, Hermann Einsele, Konrad Knöpper, Michael Hudecek, Karl Komander, Annika E. Peters
Publikováno v:
Nature Immunology
Antiviral CD8+ T cell responses are characterized by an initial activation/priming of T lymphocytes followed by a massive proliferation, subset differentiation, population contraction and the development of a stable memory pool. The transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e204e94d901cc9f4ad74dc64c480098
https://doi.org/10.1038/s41590-020-0786-2
https://doi.org/10.1038/s41590-020-0786-2
The capacity to develop immunological memory is a hallmark of the adaptive immune system. To investigate the role of Samd3 for cellular immune responses and memory development, we generated a conditional knock-out mouse including a fluorescent report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d28ed4fd2f12542364e384c17ffbd70
https://doi.org/10.1002/eji.202149469
https://doi.org/10.1002/eji.202149469