Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Wolfgang, Jahnke"'
Autor:
Louise Walsh, Daniel A. Erlanson, Iwan J. P. de Esch, Wolfgang Jahnke, Andrew Woodhead, Ella Wren
Publikováno v:
Walsh, L, Erlanson, D A, de Esch, I J P, Jahnke, W, Woodhead, A & Wren, E 2023, ' Fragment-to-Lead Medicinal Chemistry Publications in 2021 ', Journal of medicinal chemistry, vol. 66, no. 2, pp. 1137-1156 . https://doi.org/10.1021/acs.jmedchem.2c01827
This Perspective is the seventh in an annual series that summarizes successful Fragment-to-Lead (F2L) case studies published in a given year. A tabulated summary of relevant articles published in 2021 is provided, and features such as target class, s
Autor:
Iwan J. P. de Esch, Daniel A. Erlanson, Wolfgang Jahnke, Christopher N. Johnson, Louise Walsh
Publikováno v:
De Esch, I J P, Erlanson, D A, Jahnke, W, Johnson, C N & Walsh, L 2022, ' Fragment-to-Lead Medicinal Chemistry Publications in 2020 ', Journal of medicinal chemistry, vol. 65, no. 1, pp. 84-99 . https://doi.org/10.1021/acs.jmedchem.1c01803
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the pharmaceutical sciences. We summarize successful fragment-to-lead studies that were published in 2020. Having systematically analyzed annual scientific outputs since 2
Autor:
Wolfgang Jahnke, Johannes Paladini, Judith M. Habazettl, Andrea Wiget, Alice Loo, Sandra W. Cowan Jacob, Stephan Grzesiek, Paul W. Manley
Publikováno v:
Angewandte Chemie. 134
Soellner published on the interplay between allosteric and adenosine triphosphate (ATP)-competitive inhibitors of ABL kinase, showing that the latter preferably binds to different conformational states of ABL compared to allosteric agents that specif
Autor:
Georg E. Winter, Klemens Hoegenauer, Karl Heinz Krawinkler, Tobias Ritter, Vicky Steadman, Wolfgang Jahnke, Lawrence G. Hamann, Alessio Ciulli, Scott D. Williams, Amit S. Kalgutkar, Thomas Magauer, Antonia F. Stepan
Publikováno v:
ChemMedChem. 16:2417-2423
The second biannual Alpine Winter Conference on Medicinal and Synthetic Chemistry (short: Alpine Winter Conference) took place January 19-23, 2020, in St. Anton in western Austria. There were roughly 180 attendees from around the globe, making this m
Autor:
Johanna M Jansen, Charles Wartchow, Wolfgang Jahnke, Susan Fong, Tiffany Tsang, Keith Pfister, Tatiana Zavorotinskaya, Dirksen Bussiere, Jan Marie Cheng, Kenneth Crawford, Yumin Dai, Jeffrey Dove, Eric Fang, Yun Feng, Jean-Michel Florent, John Fuller, Alvar D Gossert, Mohammad Hekmat-Nejad, Chrystèle Henry, Julia Klopp, William P Lenahan, Andreas Lingel, Sylvia Ma, Arndt Meyer, Yuji Mishina, Jamie Narberes, Gwynn Pardee, Savithri Ramurthy, Sebastien Rieffel, Darrin Stuart, Sharadha Subramanian, Laura Tandeske, Stephania Widger, Armin Widmer, Aurelie Winterhalter, Isabel Zaror, Stephen Hardy
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated
Externí odkaz:
https://doaj.org/article/935bc8e9e098406ea024047d133a1803
Autor:
J.E. van Muijlwijk-Koezen, Angelo Romasanta, I.J.P. de Esch, Wolfgang Jahnke, P.C. van der Sijde, Martine J. Smit
Publikováno v:
Romasanta, A K S, van der Sijde, P C, Smit, M J, de Esch, I J P, Jahnke, W & van Muijlwijk-Koezen, J E 2020, ' Career development in fragment-based drug discovery ', Drug Discovery Today: Technologies, vol. 37, pp. 107-116 . https://doi.org/10.1016/j.ddtec.2020.10.001
Drug Discovery Today: Technologies, 37, 107-116. Elsevier Limited
Drug Discovery Today: Technologies, 37, 107-116. Elsevier Limited
The pharmaceutical industry is highly reliant on researchers who not only possess the technical knowledge but also the professional skills to collaborate in drug development. To prepare future practitioners to thrive in this interdisciplinary environ
Autor:
Christelle Stamm, Pierre Nimsgern, Thomas Knoepfel, Jasmin Wirth, Michel Niklaus, Diana Graus-Porta, Alberto Del Rio Espinola, Dario Sterker, Michael Kiffe, Nicolas Warin, Van Huy Luu, Mario Madoerin, Robert Mah, Jacqueline Kinyamu-Akunda, Robin Alec Fairhurst, Milen Todorov, Nicole Buschmann, Sebastien Ripoche, Nils Ostermann, Inga Galuba, Philippe Couttet, Catherine Leblanc, Alexandra Buhles, Jutta Blank, Flavia Adler, Wolfgang Jahnke, Chao Zou, Joerg Berghausen, Andreas Weiss, Pascal Furet, Heiko Schadt, Johannes Voshol, Markus Wartmann, Joerg Trappe
Publikováno v:
Journal of Medicinal Chemistry. 63:12542-12573
FGF19 signaling through the FGFR4/β-klotho receptor complex has been shown to be a key driver of growth and survival in a subset of hepatocellular carcinomas, making selective FGFR4 inhibition an attractive treatment opportunity. A kinome-wide seque
Autor:
Raymond S. Norton, Wolfgang Jahnke
Publikováno v:
Journal of Biomolecular NMR. 74:473-476
Autor:
Wolfgang Jahnke, José A. Márquez, Andreas Marzinzik, Irina Cornaciu, Christian Schleberger, Lena Münzker, Joy Kristin Petrick, Gerhard Klebe, Rainer Wilcken, Damien Clavel
Publikováno v:
ChemBioChem. 21:3096-3111
Trypanosoma brucei is the causative agent of human African trypanosomiasis (HAT). Nitrogen-containing bisphosphonates, a current treatment for bone diseases, have been shown to block the growth of the T. brucei parasites by inhibiting farnesyl pyroph
Autor:
Stefan Schütz, Christian Bergsdorf, Benedikt Goretzki, Andreas Lingel, Martin Renatus, Alvar D. Gossert, Wolfgang Jahnke
Publikováno v:
Journal of Molecular Biology. 434:167833
The intrinsically disordered protein MYC belongs to the family of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors (TFs). In complex with its cognate binding partner MAX, MYC preferentially binds to E-Box promotor sequences where