Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wolfgang, Holla"'
Publikováno v:
ARKIVOC, Vol 2012, Iss 3, Pp 257-278 (2012)
Externí odkaz:
https://doaj.org/article/35845550351f4fc99e5ae1e74dae5bd6
Autor:
Jens Atzrodt, Friedemann Schmidt, Kerstin Wäse, Jacquelyn Dwyer, Wolfgang Holla, Martina Dorau, Alexander Amberg, Volker Derdau, József Pánczél, Angela Dudda, Ulrich Kürzel, Dietmar Weitz, Elisabeth Defossa, Catherine Arabeyre, Markus Kohlmann, Timothy Ackerson, Jens Riedel, Thomas Kissner, Shibani Rajanna
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 33
For fasiglifam (TAK875) and its metabolites the substance-specific mechanisms of liver toxicity were studied. Metabolism studies were run to identify a putatively reactive acyl glucuronide metabolite. In vitro cytotoxicity and caspase 3/7 activation
Autor:
Glenn Gröbe, Martin Sandvoss, Martin Hofrichter, Wolfgang Holla, Marzena Poraj-Kobielska, Jens Atzrodt, Katrin Scheibner
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 56:513-519
Enzymatic conversion of a drug can be an efficient alternative for the preparation of a complex metabolite compared with a multi-step chemical synthesis approach. Limitations exist for chemical methods for direct oxygen incorporation into organic mol
Autor:
Jens Atzrodt, Lorenz Neubert, Sebastian Imm, Wolfgang Holla, Matthias Beller, Volker Derdau, Helfried Neumann, Sebastian Bähn, Dirk Michalik
Publikováno v:
Journal of the American Chemical Society. 134:12239-12244
A novel and convenient protocol for the catalytic hydrogen-deuterium exchange of biologically active tertiary amines utilizing the borrowing hydrogen methodology has been developed. In the presence of the readily available Shvo catalyst, excellent ch
Publikováno v:
ARKIVOC, Vol 2012, Iss 3, Pp 257-278 (2012)
Autor:
Stephan Enthaler, Udo Kragl, Daniel Schichl, Thomas Dr. Riermeier, Wolfgang Holla, Matthias Beller
Publikováno v:
European Journal of Organic Chemistry. 2008:3506-3512
A convenient procedure for the racemization of α-amino acid esters in the presence of catalytic amounts of salicylaldehydes is described. The combination of this racemization protocol with lipase-catalyzed ester hydrolysis allows successful dynamic
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:295-299
A safe, user friendly and efficient method to provide high deuterium incorporation into a variety of organic substrates was developed. Systematic screening of catalysts and activators revealed that the activation of the Pd- or Rh-catalyst by NaBD 4 i
Autor:
Glenn Gröbe, Marzena Poraj-Kobielska, Katrin Scheibner, Johannes Heidrich, Wolfgang Holla, Reiner Simonis, Martin Hofrichter, Jens Atzrodt, Jan Kiebist, Martin Sandvoss
Publikováno v:
Bioorganicmedicinal chemistry. 23(15)
Unspecific peroxygenases (UPOs, EC 1.11.2.1) have proved to be stable oxygen-transferring biocatalysts for H2O2-dependent transformation of pharmaceuticals. We have applied UPOs in a drug development program and consider the enzymatic approach in par
Publikováno v:
The Journal of Organic Chemistry. 63:5658-5661
Autor:
Matthias Beller, Bernd Napierski, E. Wolfgang Holla, Holger Geissler, Markus Eckert, Heinz-Peter Rebenstock
Publikováno v:
Chemistry – A European Journal. 4:935-941
A “state of the art” route to enantiomerically pure synthetic α-amino acids on a multigram scale from commonly available starting materials (below) is described; it relies on the combination of palladium-catalyzed amidocarbonylation and enantios