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Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells
Autor:
Wolfgan Wiechert, Wolf B. Frommer, Bi Huei Hou, Li Qing Chen, Xiao Qing Qu, Guido Grossmann, Oliver Schweissgut, Alexander M. Jones, Hitomi Takanaga, Sylvie Lalonde
Publikováno v:
Nature Protocols. 6:1818-1833
Knowledge of the in vivo levels, distribution and flux of ions and metabolites is crucial to our understanding of physiology in both healthy and diseased states. The quantitative analysis of the dynamics of ions and metabolites with subcellular resol